A5082146801- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- Pediatric Hepatobiliary Diseases and Treatments
- Diabetes and associated disorders
- Drug-Induced Hepatotoxicity and Protection
- Amoebic Infections and Treatments
- Adrenal and Paraganglionic Tumors
- Gastric Cancer Management and Outcomes
- Animal Virus Infections Studies
- HIV/AIDS drug development and treatment
- Pericarditis and Cardiac Tamponade
- HIV, Drug Use, Sexual Risk
- Drug Transport and Resistance Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vaccine Coverage and Hesitancy
- Organ Transplantation Techniques and Outcomes
- Urticaria and Related Conditions
Hospital de Santa Maria
2002-2019
Centro Hospitalar Lisboa Norte
2012-2019
Clinics Hospital of Ribeirão Preto
2019
University of Lisbon
1979-2018
Kanazawa University
2015
Takano Hospital
1998
Azienda Ospedaliero Universitaria San Giovanni Battista
1988
Abstract Background and aims The role of portal vein thrombosis (PVT) in the natural history cirrhosis is controversial. There are few prospective studies validating risk factors for development PVT. We analysed incidence, associated with PVT its influence on decompensations orthotopic liver transplant (OLT)‐free survival. Methods In this observational study between January 2014 March 2019, 445 consecutive patients chronic disease were screened finally 241 included. Factors OLT‐free survival...
Spontaneous bacterial peritonitis (SBP) is a known complication of advanced cirrhosis and presents high mortality rate. A polymorphonuclear (PMN) cell count >250/μl in the ascitic fluid current gold standard for diagnosing SBP.We evaluated accuracy point-of-care test (POCT) calprotectin patients with SBP.Eighty-eight admitted decompensation liver were studied including 41 (46.6%) SBP. Ascitic was measured using quantitative POCT developed by Bühlmann® .Calprotectin levels correlated PMN...
Abstract: Introduction: Hepatocellular carcinoma is a leading cause of death from cancer worldwide. Survival patients depends on tumor extension and liver function, but yet there no consensual prognostic model. Aims: To evaluate the influence survival pretreatment parameters (clinico‐laboratorial, extension, Okuda Cancer Liver Italian program (CLIP) staging) treatment modalities. Methods: We retrospectively analyzed 207 patients, diagnosed between 1993 2003. The initial was: surgery – six...
Abstract Background & Aims Chronic liver disease is a major worldwide cause of morbidity and mortality. Palliative care policies are not clearly established in chronic disease. The NECPAL CCOMS ‐ ICO © ( NEC esidades PAL iativas/Palliative Needs) tool to identify palliative needs, including section for Aim: aim this study was needs patients hospitalised tertiary referral Liver Unit. Methods Single‐centre prospective observational study. One hundred twenty with cirrhosis were included...
Clastogenic factors (CFs) are composed of lipid peroxidation products, cytokines and other oxidants with chromosome-damaging properties. They regularly observed after radiation exposure in chronic inflammatory diseases, where they supposed to be risk for carcinogenesis. It appeared interest investigate their presence the plasma patients hepatitis C.CFs detected by chromosomal breakage studies. were compared malondialdehyde (MDA), total thiols (t-SH), alanine aminotransferase (ALT), viral...
In this work the identification and diagnosis of various stages chronic liver disease is addressed. The classification results a support vector machine, decision tree k-nearest neighbor classifier are compared. Ultrasound image intensity textural features jointly used with clinical laboratorial data in staging process. classifiers training performed by using population 97 patients at six different leave-one-out cross-validation strategy. best obtained machine radial-basis kernel, 73.20%...
There are a few reports in the literature concerning pemphigus induced by interferon given for hepatitis C. We present case of 28-year-old woman with post-transfusional chronic C who developed ulcers and vesicles on her tongue, cheeks, posterior oropharynx vocal cords 5 months after beginning treatment recombinant alpha-2a. The direct indirect immunofluorescence was diagnostic vulgaris. drug promptly withdrawn; patient medicated prednisolone azathioprine recovered only 3 later. Although...
Pruritus is a major symptom of primary biliary cirrhosis, cholestatic autoimmune disease which affects mostly middle-age women. Often, it can be severe and refractory to multiple treatments, affecting the patient's health-related quality life. Intense pruritus itself an indication liver transplantation, in extreme cases leading suicide. Its physiopathology has not yet been fully elucidated, but recent studies added elevation autotaxin lysophosphatidic acid group classic mechanisms already...
The mechanisms of hepatocyte damage and the events that lead to high rates chronic liver disease in hepatitis C virus (HCV) infection remain unclear. Recent vitro studies have suggested HCV core protein may disrupt specific signalling pathways apoptosis. This prompted us study patients with to: determine extent apoptosis liver; evaluate whether clinical biochemical data are correlated histological findings; investigate if is related activity disease. Twelve were included study. Liver...
Chronic Liver Disease is a progressive, most of the time asymptomatic, and potentially fatal disease. In this paper, semi-automatic procedure to stage disease proposed based on ultrasound liver images, clinical laboratorial data. core algorithm two classifiers are used: k nearest neighbor Support Vector Machine, with different kernels. The were trained multi-modal feature set results obtained compared set. showed that using features, in association improve classification accuracy. support...
The antiviral treatment of Hepatitis C virus (HCV) infection is changing rapidly. Peginterferon and ribavirin are no longer the standard care therapy being replaced by new drugs with greater efficacy fewer adverse effects. These direct-acting antivirals (DAAs), incorporated in interferon-based or all-oral regimens, cure more than 90% infections, even patients before considered difficult to treat, such as cirrhotic non-responders. agents allow shortening duration, improving sustained response...
Objective: To evaluate the prevalence of anti-hepatitis A virus (HAV) in an urban population, order to assess changing epidemiological pattern hepatitis A. Subjects: We studied 325 health care workers from Santa Maria Hospital and 201 students Medical School Lisbon. Results: The anti-HAV was lower younger age groups: 29% first 3 years Faculty compared 46% last years, P<0.001. overall for 35%, whereas less than 30 it 65%, These findings show a declining anti-HAV, particularly groups, when...
We determined the prevalence of hepatitis B markers and compliance to vaccination in a University Hospital Santa Maria, Lisbon. The program was begun 1989 for all hospital personnel students medical school. screening included 2,360 health care workers 1,153 students; 57% (2,360/4,103) 41% (1,153/2,779) appeared vaccination. 16.8% (397/2,360) 5.5% (64/1,153) students, chronic carrier appearing 0.95% (22/2,360) 0.3% (4/1,153) students. departments with highest were Biochemical Laboratory (64%,...
We report the case of a 68-year-old African woman who presented with jaundice, hepatomegaly and anasarca. Clinical investigation disclosed severe intrahepatic cholestasis, nephrotic syndrome, erythrocytosis hypoglycemia. Diagnosis systemic AL amyloidosis was established by percutaneous liver biopsy. Bone marrow biopsy showed 32% myeloma cells. The patient started treatment melphalan prednisolone, but function deteriorated she died in hepatic failure complicated septic shock three weeks after...