Hypoxia-ischemia (HI) in rat pups leads to strong activation of apoptosis, and apoptosis contributes significantly cerebral damage the perinatal period. Caffeine displays a broad array actions on brain. The aim this study was investigate effects caffeine neuronal hypoxic-ischemic neonatal model.Twenty-four seven-day-old Wistar were subjected right common carotid artery ligation hypoxia for 2 h. Sham group (n = 8) had median neck incision, but rats not or hypoxia. treated with 20 mg/kg/day...

This study aimed to view the antioxidant and anti–inflammatory properties of Helichrysum plicatum DC. subsp. (HP) methanol extract on urinary tract using an experimentally induced urolithiasis (U) model. The included four groups: Group 1 was given a standard diet, 2 diet added with HP, 3 urolithiasis, 4 received HP–supplemented urolithiasis. Rats in Groups were administered 500 mg·kg-1·day-1 HP via gavage feeding for 21 days. Urolithiasis by administering 1% ethylene glycol ammonium chloride...

This study explored the effects of comfrey (Symphytum officinale) on treating third–degree burns in a rat model, demonstrating promising results. A hot iron created standardized burns, after which three groups rats received different treatments: no treatment (control), vaseline, or 20% ointment. Histopathological assessments at 7 days and 14 marks showed accelerated healing comfrey–treated group compared to control, indicating comfrey’s potential for enhancing wound recovery. Additionally,...

The genotoxic and antigenotoxic effects of Aloe vera leaf extract (AV) were investigated using the chromosome aberrations (CAs) test for bone marrow cells rats, sister chromatid exchanges (SCEs) micronucleus (MN) CAs tests human lymphocytes, Ames Salmonella/microsome system. In AV significantly induced structural total at all concentrations in treatment periods. peripheral did not increase mean SCE; however, it MN frequency CAs. addition, showed a cytotoxic effect by decreasing replication...

Background. Recent reports have indicated an improved prognosis in sepsis with β-blocker agents; however, the underlying action mechanism is still under debate.Objectives. The aim of this study was to investigate potential effect propranolol on endothelial dysfunction septic rats.Material and Methods. cecal ligation puncture model (CLP) used generate sepsis. Adult male Wistar-Albino rats were divided into 4 groups: group 1 a sham group, 2 received sterile saline, 3 10 mg/kg days before...

The aim of this study was to investigate the effects pterostilbene (PTS) (trans-3,5-dimethoxy-4'-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4' trihydroxystilbene) applied at different doses for treatment streptozotocin- (STZ-) induced diabetic rats.At end 5-week experimental period, right gastrocnemius muscles rats were examined biomechanically, while left ones histologically. In addition, blood glucose, serum insulin, malondialdehyde (MDA) levels analyzed in samples taken from...

Purpose: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. Methods: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) glue(Tisseel VH) 3). The colon was transected with scissor subsequently an end anastomosis performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day healing measuring tissue hydroxyproline(TH) level bursting pressure(ABP); moreover comparison cytokine (IL-6...

Peripheral nerve injury (PNI) is a major health problem that results in loss of motor and sensory functions. In treatment PNI, various methods such as anastomosis, grafts, nonneural tissue conduits are applied. the present study, it was aimed to investigate effects Theranekron Alpha-lipoic acid (ALA) combined on healing experimental PNI by using histomorphometric, electron microscopic, immunohistochemical molecular biological methods. Sixty-two Wistar rats were divided into six groups;...

We aimed to research whether lycopene (L) could prevent radiation-induced acute esophageal toxicity in Wistar albino rats. 60 rats were placed five groups as follows: control, L, radiotherapy (RT), L before RT (L + RT), and after L). 6 mg/kg bw/day was administered 7 days the group, group. 35 Gy thoracic performed. Serum levels measured, esophagi evaluated histopathologically for intraepithelial degenerative changes-necrosis, vacuole formation, inflammation, regeneration-mitosis,...

Objective The objective of this study was to compare the histological regeneration characteristics nerve fibers at anastomosis lines performed by classic suture technique or a tissue adhesive (N-butyl-2-cyanoacrylate). Methods control group consisted 7 rabbits. 21 rabbits were randomly divided into 3 groups based on harvesting week. In following preparation facial bilaterally, 0.5-cm segment dorsal buccal resected, and defect repaired with graft, which harvested from sural same side 8-0...

SUMMARY OBJECTIVE: The objective of this study was to investigate the protectiveness resveratrol on cisplatin-induced damage ovary using experimental models. METHODS: A total 30 female Wistar-Albino rats constituted research material. were categorized into three groups: Group 1 administered one milliliter 0.9% NaCl solution, 2 7.5 mg/kg cisplatin, and 3 cisplatin 10 resveratrol. Ovaries extirpated in all groups subjected biochemical histopathological tests. Cisplatin-induced ovarian tissue...

After a peripheral nerve injury, ion channel organization and the electrical properties of fibers drastically change during regeneration process. The present study was designed to compare frequency-dependent characteristics regenerating nerves in presence 4-aminopyridine (4-AP) tetraethylammonium (TEA). results showed that increasing stimulus frequency produced greater impulse blockade (frequency-dependent block--FDB) distinct hyperpolarizing afterpotentials (HAPs) nerves. In particular,...

In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), administered at 5 mg/kg/days for 7 days, RT (RT), before (J + RT), seven days RT, both and after J), 3 days. The weights rats measured on the 1st, 7th, 10th study. sacrificed to obtain tissues from liver intestine, which was followed by taking blood samples...

Fucoidan is a sulfated polysaccharide which can be found among number of macroalgea species. It has broad spectrum biological activities including anti-oxidant, anti-tumor, immunoregulation, anti-viral and anti-coagulant. The current study was performed to investigate possible protective effects fucoidan for sulfoxaflor-induced hematological/biochemical alterations oxidative stress in the blood male Swiss albino mice. For this purpose, sulfoxaflor administered at dose 15 mg/kg/day (1/50 oral...

Necrotizing enterocolitis has been investigated and debated extensively in recent years; however, there is still no effective treatment. The aim of this study was thus to examine the effects β-estradiol on intestinal injury rats.Twenty-four newborn female rat pups were divided into three groups. In group 1 (sham), hypoxia-re-oxygenation not performed. 2 (saline), rats injected with saline after hypoxia-re-oxygenation, process repeated for 5 d. 3 (β-estradiol treatment), subjected then given...

Purpose: We investigated the effects of Quercetin and Coenzyme Q10 antioxidant, on gentamicin-induced renal failure in rats. Materials Methods: The rats were given gentamicin (100 mg/kg/day, i.m., once a day), i.m.once day) + (15 mg/kg i.p. i.m.) (8 i.m. day). Results: In control BUN value was 26.8 ± 0.8 (mg/100 mL); whereas, it 117.3 15.4 group. Renal histopathologic examination confirmed acute tubular necrosis this treated with Q10, partial improvement biochemical histologic parameters...

Abstract This research aimed to determine regulatory role of sulfated polysaccharides fucoidan from Fucus vesiculosus against oxidative and transcriptional responses in liver sulfoxaflor exposed mice liver. Fort this purpose both were given orally for 24 hours 7 days at doses 15 mg/kg/day (equivalent 1/50 oral LD 50 ) mg/kg/day. At the end tests, samples collected used assess 8-OHdG levels, mRNA expression levels DNA damage response genes such as XRCC1, OGG1, APE1, PARP1. Furthermore, tGSH...

Background: One of the most important complications wound is tissue infection. common causes infections microorganisms such as Staphylococcus. This research investigates impact argan oil and polyhexanide on healing process in wounds with loss infected Staphylococcus aureus (S. aureus). Methods: The study involved 45 male mice, 10 mm skin incisions made their backs under general anaesthesia to create wounds. After 24 hours, an S. (ATCC) suspension was applied scars. Wound cultures were...

We aimed to create a mechanical optic nerve damage model in rats and investigate the neuroprotective effects of topical Coenzyme Q10 + Vitamin E TPGS (CoQ10+Vit E) molecule on retinal ganglion cells. In our study, 30 eyes 20 male Wistar were used. Three groups, each consisting 10 eyes, formed as control, experimental, treatment groups. The control group was used test formation damage. Topical CoQ10 Vit solution applied group, one drop twice day for 3 weeks. On other hand, physiological drops...