A5019736586- Neonatal and fetal brain pathology
- Heart Rate Variability and Autonomic Control
- Fetal and Pediatric Neurological Disorders
- Non-Invasive Vital Sign Monitoring
- Congenital Heart Disease Studies
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiac Arrest and Resuscitation
- Mosquito-borne diseases and control
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Advanced Neuroimaging Techniques and Applications
- Phonocardiography and Auscultation Techniques
- Neuroscience of respiration and sleep
- Pregnancy and preeclampsia studies
- Uterine Myomas and Treatments
- ECG Monitoring and Analysis
- Optical Imaging and Spectroscopy Techniques
- Endometriosis Research and Treatment
- Prenatal Screening and Diagnostics
- Virology and Viral Diseases
Children's National
2016-2025
George Washington University
2016-2025
National Hospital
2022-2025
University of the Free State
2003-2024
RELX Group (United States)
2018
Johns Hopkins Medicine
2017
Johns Hopkins University
2017
Society for Maternal-Fetal Medicine
2016
Transitional Learning Center
2016
Fetal Medicine Foundation
2016
The current outbreak of Zika virus (ZIKV) infection has been associated with an apparent increased risk congenital microcephaly. We describe a case pregnant woman and her fetus infected ZIKV during the 11th gestational week. fetal head circumference decreased from 47th percentile to 24th between 16 20 weeks gestation. RNA was identified in maternal serum at 21 At 19 gestation, substantial brain abnormalities were detected on ultrasonography magnetic resonance imaging (MRI) without presence...
Premature infants experience brain injury, ie, germinal matrix-intraventricular hemorrhage (GMH-IVH) and periventricular leukomalacia (PVL), in considerable part because of disturbances cerebral blood flow (CBF). Because such are susceptible to major fluctuations mean arterial pressure (MAP), impaired cerebrovascular autoregulation would increase the likelihood for changes CBF that could result GMH-IVH PVL. The objectives this study were determine whether a state be identified reliably...
This study characterizes global and hemispheric brain growth in healthy human fetuses during the second half of pregnancy using three-dimensional MRI techniques. We studied 166 that underwent between 18 39 completed weeks gestation. created high-resolution reconstructions calculated volumes for left right cortical gray matter (CGM), fetal white (FWM), deep subcortical structures (DSS), cerebellum. rate each tissue class according to gestational age described patterns growth. Each region...
Prenatal maternal psychological distress can result in detrimental mother and child outcomes. Maternal stress increases with receipt of a prenatal diagnosis fetal congenital heart disease (CHD); however, the association between developing brain fetuses CHD is unknown.To determine development CHD.This longitudinal, prospective, case-control study consecutively recruited 48 pregnant women carrying 92 healthy volunteers low-risk pregnancies from Children's National Health System January 2016...
Our prospective cohort study of extremely low gestational age newborns evaluated the association neonatal head ultrasound abnormalities with cerebral palsy at 2 years. Cranial ultrasounds in 1053 infants were read respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified palsy, functional impairment was assessed. Forty-four percent ventriculomegaly 52% echolucency developed palsy. Compared no...
Brain structural changes in premature infants appear before term age. Functional differences between and healthy fetuses during this period have yet to be explored. Here, we examined brain connectivity using resting state functional MRI 25 very (VPT; gestational age at birth <32 weeks) with structurally normal MRIs. Resting data were evaluated seed-based correlation analysis network-based statistics 23 regions of interest (ROIs) per hemisphere. strength, the Pearson blood oxygenation level...
<h3>Importance</h3> Children raised in settings with lower parental socioeconomic status are at increased risk for neuropsychological disorders. However, to date, the association between and fetal brain development remains poorly understood. <h3>Objective</h3> To determine vivo growth cerebral cortical using advanced, 3-dimensional magnetic resonance imaging. <h3>Design, Setting, Participants</h3> This cohort study of enrolled 144 healthy pregnant women from 2 low-risk community obstetrical...
Elevated maternal psychological distress during pregnancy is linked to adverse outcomes in offspring. The potential effects of intensified levels the COVID-19 pandemic on developing fetal brain are currently unknown.
To compare the predictive value for adverse outcome of quantitative cerebral lactate level and apparent diffusion coefficient (ADC) in infants with perinatal asphyxia early postnatal period.Lactate-choline ratios determined proton magnetic resonance (MR) spectroscopy ADC MR imaging basal ganglia thalami 26 full-term neonates (age range, 1-10 days) were compared severity acute hypoxic-ischemic encephalopathy long-term clinical outcome. Differences metabolites between groups evaluated...
To characterize the delivery and postnatal neurodevelopmental outcomes of fetuses referred for ventriculomegaly (VM).
<h3>BACKGROUND AND PURPOSE:</h3> Brain injury in neonates with congenital heart disease is an important predictor of adverse neurodevelopmental outcome. Impaired brain development may have a prenatal origin, but the sensitivity and specificity fetal MR imaging for predicting neonatal lesions are currently unknown. We sought to determine value conventional abnormal findings on preoperative complex disease. <h3>MATERIALS METHODS:</h3> studies were performed 103 fetuses confirmed (mean...
Background It is unknown whether intraoperative hyperglycemia in infants associated with worse neurodevelopmental outcomes after low-flow cardiopulmonary bypass (LF), deep hypothermic circulatory arrest (CA), or both. Methods In a database review of prospective trial 171 undergoing arterial switch for D-transposition the great arteries who were randomly assigned to predominantly LF CA, glucose was measured induction (T1), 5 min onset (T2), at CA (T3), CPB resumption (T4), rewarming 32...
Twenty-four children with Williams syndrome underwent systematic neurologic evaluations. Abnormalities of mental status, motor coordination, tone, and gait were most prevalent. Tone abnormalities varied as a function age, younger frequently exhibiting decreased tone older subjects almost exclusively having increased tone. The coordination persisted among subjects, indicating that they not simply maturational problems. Physicians caring for such youngsters need to be aware variety are common...
To date, prenatal diagnosis of intracranial hemorrhage (ICH) is mainly based on ultrasound (US) findings rather than magnetic resonance imaging (MRI). We aimed to investigate the role MRI in fetal ICH among pregnancies referred and characterize topography using MRI.We retrospectively identified cases diagnosed by from 2008 2015 reviewed their postnatal medical records.Of 2638 MRIs performed during study period, 36 had (median age 27 weeks). The most common US indication for was a suspected...
<h3>BACKGROUND AND PURPOSE:</h3> <sup>1</sup>H-MRS provides a noninvasive way to study fetal brain maturation at the biochemical level. The purpose of this was characterize in vivo metabolic healthy during second and third trimester using <sup>1</sup>H-MRS. <h3>MATERIALS METHODS:</h3> Healthy pregnant volunteers between 18 40 weeks gestational age underwent single voxel MR spectra were retrospectively corrected for motion-induced artifacts quantified LCModel. Linear regression used examine...
To characterize the mechanism of Zika virus (ZIKV)-associated microcephaly, we performed immunolabeling on brain tissue from a 20-week fetus with intrauterine ZIKV infection. Although demonstrated wide range neuronal and non-neuronal tropism, infection rate was highest in intermediate progenitor cells immature neurons. Apoptosis observed both infected uninfected bystander cortical neurons, suggesting role for paracrine factors induction apoptosis. Our results highlight differential...