A5101642918- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Structure and Function
- Complement system in diseases
- Protein Structure and Dynamics
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroscience and Neuropharmacology Research
- Nanoparticle-Based Drug Delivery
- Retinoids in leukemia and cellular processes
- Advanced Nanomaterials in Catalysis
- Lipid Membrane Structure and Behavior
- Enzyme Production and Characterization
- Pediatric health and respiratory diseases
- Signaling Pathways in Disease
- Salivary Gland Tumors Diagnosis and Treatment
- Barrier Structure and Function Studies
- Lipid metabolism and disorders
- Oral microbiology and periodontitis research
Qingdao University
2011-2024
State Key Laboratory of Natural Medicine
2024
China Pharmaceutical University
2024
Tianjin University of Science and Technology
2012
University of Louisville
2003
University of Alabama at Birmingham
1990-1997
Ascorbic acid (AA) has been attracting great attention with its emerging potential in T cell-dependent antitumor immunity. However, premature blood clearance and immunologically "cold" tumors severely compromise immunotherapeutic outcomes. As such, the reversal of immunosuppressive tumor microenvironment (TME) premise for improving effectiveness AA-based immunotherapy, which hinges upon advanced AA delivery amplified immune-activating strategies. Herein, a novel Escherichia coli (E. coli)...
The activation of cyclic GMP-AMP synthase (cGAS) and stimulator interferon genes (STING) has been recognized as one the most promising immunotherapeutic strategies to induce innate antitumor immune responses. However, it is far from effective just activate cGAS-STING pathway, owing abundant immunosuppressive cells that infiltrate tumor microenvironment (TME) impair immunity. Here, we present smart design biodegradable Mn-doped mesoporous silica (MM) nanoparticles with metal–organic framework...
The effects of C-phycocyanin (C-PC) on atherosclerosis and the regulatory CD59 gene anti-atherosclerotic roles C-PC were investigated. Apolipoprotein E knockout (ApoE(−/−)) mice randomly divided into four groups: control group, treatment transfection group C-PC+CD59 synergy group. fed with high-fat-diet treated drug intervention at same time. Results showed atherosclerotic mouse model was successfully established. over-expressed in blood tissue cells. Single or could reduce lipid levels...
The purpose of this research was to obtain the mutant Bacillus licheniformis alpha amylase (BLA) with an improved acid stability and elucidate difference in catalytic mechanism under acidic conditions between wild-type BLAs.The BLA condition enhanced through direct evolution using error-prone polymerase chain reaction. Two mutation sites, T353I H400R, were obtained BLA. To identify amino acids Thr353Ile/His400Arg related its stability, single mutants Thr353Ile His400Arg via site-directed...
Human C-reactive protein (CRP) can activate the classical pathway of complement and function as an opsonin only when it is complexed to appropriate ligand. Most known CRP ligands bind phosphocholine (PCh)-binding site protein. In present study, we used oligonucleotide-directed site-specific mutagenesis investigate structural determinants PCh-binding CRP. Eight mutant recombinant (r) CRP, Y40F; E42Q; Y40F, K57Q; R58G; K57Q, W67K; R58G, W67K were constructed expressed in COS cells. Wild-type...
We studied the effects of all-trans-retinoic acid (ATRA), C-phycocyanin (C-PC), or ATRA + C-PC on growth cervical cells (HeLa cells), cell cycle distribution, and apoptosis. The anticancer mechanism drug combination was revealed. MTT assay adopted to determine HeLa cells. expression quantities cyclin-dependent kinase (CDK) 4, cyclin D1, Bcl-2, caspase-3, CD59 were determined by in situ hybridization, immunofluorescence, immunohistochemistry staining, Western blot, RT-PCR. TUNEL cellular...
Periodontitis is a chronic inflammatory disease that the main cause of tooth loss in adults, and key to periodontitis treatment repair regenerate periodontal bone tissue. Psoralen component Psoralea corylifolia Linn, which shows antibacterial, anti-inflammatoryand osteogenic activities. It promotes differentiation ligament stem cells toward osteogenesis. Exosomes secreted by play important roles information transmission during process. The aim this paper was investigate role psoralen...
To identify the complement control protein (CCP) module(s) of C2 that are required for C4b recognition, we constructed a panel C2/factor B chimeras by substituting intact or partial factor CCP modules corresponding ones C2. Epitope mapping indicated anti-C2b mAb 3A3.3, which inhibits binding to C4b, reacts with second and similarly anti-Ba HA4-1A, C3b, B. The hemolytic activity CP1, CP2, CP3a containing CCP1, CCP2, fragment CCP3 B, respectively, was substantially decreased compared wild-type...
Periodontitis is an inflammatory disease characterized by the destruction of periodontal tissues, and promotion bone tissue regeneration key to curing periodontitis. Psoralen main component Psoralea corylifolia Linn, has multiple biological effects, including anti-osteoporosis osteogenesis. We constructed a novel hydrogel loaded with psoralen (PSO) stromal cell-derived factor-1 (SDF-1) for direct endogenous cell homing. This study aimed evaluate synergistic effects PSO/SDF-1 on in patients...
Previous studies have demonstrated the relationship of occludin expression to endothelial layer permeability; but none determined between prolonged exposure shear stress and expression. The purpose this study is determine effects varying fluid on regulation in cells after cell realignment. A flow system, which consisted four parallel plate chambers, was developed order simultaneously expose human umbilical vein 0.3, 10, 20, 30 dynes/cm/sup 2/ levels stress. constant rate applied all chambers...