Sodium glucose co-transporter (SGLT-2) inhibitor is a relatively new medication used to treat diabetes. At present, the Food and Drug Administration (FDA) has only approved three medications (canagliflozin, dapagliflozin empagliflozin) in this drug class for management of Type 2 In May 2015, FDA issued warning ketoacidosis with use class. Risk factors development among patients who take SGLT-2 inhibitors include decrease carbohydrate intake/starvation, acute illness insulin dose. When...

TPS488 Background: Renal cell carcinoma (RCC) has a biologic propensity for vascular invasion leading to venous tumor thrombus (VTT) in the renal vein or inferior vena cava (IVC) up 25% of cases. RCC with VTT is poor prognostic factor cancer-related mortality. Additionally, depending on burden and extent (TT), patients can become symptomatic from VTT, affecting patients’ quality life. The current standard care an IVC TT undergo radical nephrectomy thrombectomy which may be associated high...

Object Neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte (PLR) are simple, inexpensive prognostic markers for various conditions. The objective of this study was to determine the significance NLR PLR in patients with multiple myeloma (MM) terms survival. Method A retrospective chart review conducted 175 who met criterion diagnosis MM between January 2004 September 2014. Result median age 69 years. Patients were divided into high low groups according cutoff points from receiver...

Megaloblastic anemia due to severe vitamin B 12 defi ciencyA 75-year-old man presented the hos- pital with altered mental status and pancytopenia.He had a history of schizophrenia gastrointestinal bleeding peptic ulcer disease, for which he undergone subtotal gastrectomy.Results complete blood cell count at presentation showed following: • Hemoglobin 5.5 g/dL (reference range 14.5-18.1)• Hematocrit 17.5% (42.0-54.0)• Mean corpuscular volume 108.7 fL (80-100) White 3.5 × 10 9 /L (4.41-10.05)•...

<b><i>Background:</i></b> The public health burden of cancer and dementia in the geriatric population is well documented. There limited data on how predicts mortality among patients with solid tumors. objective this study to determine prognostic significance survival <b><i>Methods:</i></b> We performed a 5-year retrospective elderly subjects aged ≥60 years without that were diagnosed <b><i>Results:</i></b> Among 3,460...

Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory condition characterised by calcification and ossification of the vertebral ligaments. It most commonly seen to affect thoracic lumbar vertebrae usually among elderly men. The cause this unknown. Risk factors include male gender, obesity, diabetes advancing age. majority these cases are found incidentally on imaging patients generally asymptomatic. Cervical DISH less common than its counterparts. When symptomatic, it can...

Introduction: Renal cell carcinoma (RCC) has a predisposition to vascular invasion that manifest as an inferior vena cava tumor thrombus (IVC TT). Radical nephrectomy with IVC thrombectomy is associated high morbidity. We present our single-center experience on the neoadjuvant use of combination anti-vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKI) and immune check point inhibitor (IO) for patients RCC TT. Patient Methods: Five TT received anti-VEGF TKI IO. The...

90 Background: Breast cancer is one of the most common types cancer. Taxanes are used to treat both early and metastatic breast Chemotherapy-induced peripheral neuropathy (CIPN) its dose-limiting side effect that debilitating could alter treatment outcomes. This study aims assess predictors in development severity CIPN. Methods: A retrospective review 229 patients was done identify if age, BMI, race, smoking history, alcohol use, diabetes, chronic kidney disease (CKD), estrogen (ER),...

Acquired hemophilia A (AHA) is a disease caused by antibody formation inhibiting the function of factor VIII, causing bleeding. Recombinant porcine VIII (rpFVIII) escapes human FVIII recognition and can provide life-saving hemostasis. However, development antibodies against pFVIII limit its use. We report two cases in which loss response to rpFVIII occurred, likely because antibodies. In case 1, patient achieved hemostasis but lost within few days. second case, controlled bleeding...

<ns4:p>Kikuchi-Fujimoto disease is a form of benign necrotizing lymphadenitis which most commonly misdiagnosed as tuberculosis and or lymphoma, usually more common among young adults in Asia. It but can mimic lot other processes spanning infectious, rheumatologic even hematologic malignancies. Our patient presented with prolonged fever lymphadenopathy. Initial considerations were lymphoma nonspecific viral infection. A CT scan showed diffuse cervical lymphadenopathy lacrimal gland...

A 60-year-old woman presented with melena for 2 weeks. She had undergone hysterectomy and bilateral salpingo-oophorectomy to treat clear cell endometrial carcinoma 10 months before the presentation. was anaemic tachycardic; abdominal CT scan revealed a large duodenal mass. Her gastrointestinal bleed not amenable endoscopic intervention, so she emergent laparotomy, pancreaticoduodenectomy mass excision. Histopathology confirmed that metastatic deposit from her cancer. Postoperatively, frail...

Apical hypertrophic cardiomyopathy (Yamaguchi syndrome) is a rare subtype of cardiomyopathy. The syndrome more common in Japan where it was first described. Outside Asia, very cause usually detected incidentally and has good long-term outcome. We present case apical an African-American patient manifesting as atrioventricular nodal re-entrant tachycardia.

62 Background: Patients with castrate-resistant prostate cancer (CRPC) progressive disease are generally require a change/escalation in systemic therapy. For patients limited ( ≤3) sites of (oligoprogression), metastasis-directed therapy stereotactic body radiation (SBRT) may allow longer interval before next line therapy, but there is data describing this approach. Methods: This retrospective study oligoprogressive metastatic CRPC (omCRPC) treated SBRT at single center between 2011-2022....

Sarcomatoid renal cell carcinoma (sRCC) is an aggressive form of kidney cancer that associated with poor prognosis. It can arise from any histologic type carcinoma. The majority cases will present advanced or metastatic disease requiring systemic therapy. Nephrectomy the treatment choice in locally resectable disease. therapeutic options for sRCC have evolved past decade. Cytotoxic chemotherapy and monotherapy targeted therapy (VEGF mTOR) historically shown response rates survival sRCC. use...

e12069 Background: Estrogen receptor (ER) positivity in breast tumors has a beneficial prognostic profile. However, ER-positive and progesterone (PR) negative have higher relative risk of mortality, as well ER-negative/PR-positive ER-negative/PR-negative tumors. HER 2/neu, when overexpressed, confers aggressive behavior to cancers. Ethnic differences between hormone lobular carcinoma not yet been fully described. Methods: We retrospectively ascertained patients at AEMC 2003 2011 with by...