A5009327992- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Multiple and Secondary Primary Cancers
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Urinary Bladder and Prostate Research
- Cardiac tumors and thrombi
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Abdominal Trauma and Injuries
- Renal Diseases and Glomerulopathies
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Epigenetics and DNA Methylation
- Palliative Care and End-of-Life Issues
- Urologic and reproductive health conditions
- Esophageal Cancer Research and Treatment
- Economic and Financial Impacts of Cancer
- Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Ferroptosis and cancer prognosis
Menoufia University
2025
Cairo University
2025
University at Buffalo, State University of New York
2020-2024
VA Western New York Healthcare System
2019-2024
King's College London
2024
Veterans Health Administration
2021
Buffalo General Medical Center
2019
University of California System
2017
The University of Texas Southwestern Medical Center
2012-2016
Saint Louis University
2015-2016
Abstract Objectives This randomized prospective controlled trial investigated the effectiveness of different strategies regenerative endodontic therapy on necrotic mature anterior teeth with chronic periapical periodontitis 18 months follow up. Methods A total analyzed 51 adult participant single rooted having pulp (PAI ≥ 3) were selected. Patients had been randomly categorized into three distinct groups ( n = 17 each group). All received same treatment first visit. After 2 weeks, was...
Suprahepatic inferior vena caval tumor thrombus in renal cell carcinoma cases has historically portended a poor prognosis. With advances perioperative treatment of patients with high level contemporary outcomes are hypothesized to be improved. We evaluated long-term oncologic surgical whom III-IV was managed at volume centers.We examined clinical and pathological data on treated surgery from January 2000 June 2013 4 tertiary referral centers. Survival associated prognostic variables were...
To validate the impact of Ki67 expression on oncological outcomes patients treated for clinically localized clear-cell renal cell carcinoma (ccRCC).Immunohistochemistry was performed tissue microarray constructs with radical or partial nephrectomy (M0) ccRCC and >10% considered abnormal. Clinical pathological data elements were entered into an institutional review board-approved database. The Kaplan-Meier method Cox regression models used to analyse disease-free survival (DFS)...
We determined the association of proliferation marker Ki-67 with pathological parameters and oncologic outcomes in patients high grade upper tract urothelial carcinoma.Immunohistochemical staining for was done prospectively 101 consecutive undergoing radical nephroureterectomy/ureterectomy carcinoma. Data were compared based on status (normal vs over expressed). Survival assessed by Kaplan-Meier method. Cox regression analysis to identify independent predictors time dependent outcomes.Median...
Clinically localized prostate cancer is typically managed by well established therapies like radical prostatectomy, brachytherapy, and external beam radiation therapy. While many patients can be cured with definitive local therapy, some will have biochemical recurrence (BCR) of disease detected a rising serum prostate-specific antigen (PSA). Management these nuanced controversial. The natural history indicates that majority BCR not die from but other causes. Despite this, vast are...
Upper tract urothelial carcinoma is rare and less well studied than bladder cancer. It remains questionable if findings in cancer can safely be extrapolated to upper carcinoma. We prospectively evaluate molecular profiles of using a cell cycle biomarker panel.Immunohistochemical staining for p21, p27, p53, cyclin E Ki-67 was performed 96 patients with 159 nonmetastatic high grade treated extirpative surgery. Data were compared between the groups according pathological stage. Primary outcome...
The management of patients with renal cell carcinoma (RCC) venous tumor thrombus (VTT) is challenging. We report our 15 year experience in the RCC VTT utilizing a multidisciplinary team approach, highlighting improved total and specifically Clavien III-V complication rates. reviewed records 146 consecutive who underwent radical nephrectomy thrombectomy between 1998 2012. Data on patient history, staging, surgical techniques, morbidity, survival were analyzed. Additionally, rates two eras,...
This study aims to evaluate the accuracy of transrectal ultrasound (TRUS) guided prostate biopsies in predicting pathological grading and tumour distribution final specimen patients who underwent radical prostatectomy for clinically localized cancer. The ultimately gain more understanding behaviour cancer limitations currently available diagnostic prognostic tools.We reviewed records 100 with carcinoma diagnosed by TRUS-guided biopsy treated retropubic prostatectomy, comparing laterality...
Cell cycle regulatory molecules are implicated in various stages of carcinogenesis. In this proof principle study we systematically evaluate the association aberrant expression cell regulators and proliferative markers their effect on oncologic outcomes patients with clear renal carcinoma.Immunohistochemistry for Cyclin D, E, p16, p21, p27, p53, p57 Ki67 was performed tissue microarray constructs 452 treated extirpative therapy carcinoma between 1997 2010. Clinical pathological data elements...
Epithelial-to-mesenchymal transition is thought to have a crucial role in cancer progression and metastatic egress. We evaluated the association of β-catenin, an important mediator epithelial-to-mesenchymal transition, with pathological parameters oncologic outcomes patients clear cell renal carcinoma.Immunohistochemical staining was performed for β-catenin on tissue microarrays nonmetastatic carcinoma. Membranous cytoplasmic expression patterns were assessed separately. β-Catenin considered...
Background: Partial nephrectomy is the preferred treatment method for certain kidney tumors owing to its nephron-preserving benefit. We aimed compare occurrence and importance of complications after radical (RN) or partial (PN) localized renal cell carcinoma (RCC) contribution patient mortality. Methods: All RCC cases were extracted from National Surgical Quality Improvement Program between 2005 2017. All-cause mortality was primary endpoint that defined a failure rescue (FTR) occurrences...
To improve risk stratification for recurrence prognostication in patients with localised clear cell renal carcinoma (ccRCC).In all, 367 non-metastatic ccRCC were included. The cohort was divided into a training and validation set. Using tissue microarrays, immunostaining performed 24 biomarkers representative of key pathways ccRCC. Least Absolute Shrinkage Selection Operator (LASSO) Cox regression, we identified several markers that used to construct classifier disease recurrence.The median...
Current management of high-grade blunt renal trauma favors a nonoperative approach when possible. We performed retrospective study high grade injuries at our level I center to determine the indications and success (NOM). 47 patients with IV or V were identified between October 2004 December 2013. Immediate operative (IO) compared nonoperatively managed Of patients, 3 (6.4%) IO 44 (95.6%) NOM. had higher heart rate on admission, 133 versus 100 in NOM (<mml:math...
To investigate the role of heated irrigation fluids in risk hypothermia and related complications patients undergoing transurethral procedures.The medical records all who underwent procedures between 2000 2016 at VA Hospital were reviewed. Irrigation have been to 42°C since 2013, as per institutional policy (Group II). Prior this date, room temperature solutions used I). The perioperative body temperature, use warming devices, procedure length, anaesthesia type extracted from compared for...
Secondary cancers of the penis are extremely uncommon with less than 300 cases reported in past 100 years. These most frequently a result an aggressive or poorly managed primary prostate bladder cancer and rarely metastasis from kidney tumor. Currently, there is no published literature which describes spread sarcomatoid renal cell carcinoma (SRCC) to penis. In this report, we present 55-year-old-man who presented large right-sided SRCC metastasized base his within 1 month symptom onset. We...