A5031945313- Hepatitis C virus research
- Schizophrenia research and treatment
- Mental Health Research Topics
- Machine Learning in Healthcare
- Health disparities and outcomes
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Dementia and Cognitive Impairment Research
- Mental Health Treatment and Access
- COVID-19 Pandemic Impacts
- Nutrition and Health in Aging
- Telomeres, Telomerase, and Senescence
- Health and Well-being Studies
- Chronic Disease Management Strategies
- Global Public Health Policies and Epidemiology
- COVID-19 and Mental Health
- Biochemical and Molecular Research
- interferon and immune responses
- Blood Pressure and Hypertension Studies
- Geriatric Care and Nursing Homes
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Education and Learning Interventions
Fujita Health University
2022-2025
Fujita Health University Hospital
2021-2025
AbbVie (United States)
2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
Hengyang Normal University
2024
Nagoya University
2018-2023
Wuhan Donghu University
2020
Abbott Fund
2004-2014
Abbott (United States)
2007-2009
Although hepatitis C virus (HCV) infection is an emerging global epidemic causing severe liver disorders, the molecular mechanisms of HCV pathogenesis remain elusive. The NS5A nonstructural protein contains several proline-rich sequences consistent with Src homology (SH) 3-binding sites found in cellular signaling molecules. Here, we demonstrate that specifically bound to growth factor receptor-bound 2 (Grb2) adaptor protein. Immunoblot analysis anti-Grb2 immune complexes derived from HeLa...
ABSTRACT Hepatitis C virus (HCV) sets up a persistent infection in patients that likely involves complex virus-host interaction. We previously found the HCV nonstructural 5A (NS5A) protein interacts with growth factor receptor-binding 2 (Grb2) adaptor and inhibits activation of extracellular signal-regulated kinases 1 (ERK1/2) by epidermal (EGF). In present study, we extended this analysis investigated specificity Grb2-NS5A interaction whether subversion mitogenic signaling additional...
Hepatitis C virus (HCV) replication is highly dependent on host cell factors. Identification of these factors not only facilitates understanding the biology HCV infection but also enables discovery novel targets for anti-HCV therapy. To identify genes important RNA replication, we screened a library small interfering (siRNA) that approximately 4,000 human in Huh7-derived EN5-3 cells harboring an subgenomic replicon with nonstructural region NS3-NS5B from 1b-N strain. Nine cellular...
We characterized the selective advantage profiles of a panel hepatitis C virus (HCV) NS3 protease mutants with three HCV inhibitors (PIs), BILN-2061, ITMN-191, and VX-950, using genotype 1b replicon system. Selective curves were generated by novel mathematical method that factors in degree drug susceptibility provided mutation, base-level replication capacity mutant absence drugs, overall viral levels as function concentration. Most showed significantly increased advantages over wild-type...
The physical, psychiatric, and social comorbidities interfere with the everyday activities of community-dwelling individuals schizophrenia increase risk their readmission. However, these have not been investigated comprehensively in Japan. We conducted a self-reported internet survey February 2022 to identify aged 20–75 years without using prevalence case-control study. compared physical such as being overweight, hypertension, diabetes; psychiatric depressive symptoms sleep disturbances;...
Hepatitis C virus (HCV), the global leading cause of chronic liver disease, has a positive-sense, ssRNA genome that encodes large polyprotein. HCV polyprotein translation is initiated by an internal ribosome-entry site (IRES) located at 5' end viral genome, in cap-independent manner, but regulatory mechanism this process remains poorly understood. In study, we characterized effect nonstructural proteins on IRES-directed both replicon cells and transiently transfected human expressing...
Abstract Background Estimating the prevalence of schizophrenia in general population remains a challenge worldwide, as well Japan. Few studies have estimated Japanese and often relied on reports from hospitals self-reported physician diagnoses or typical symptoms. These approaches are likely to underestimate true owing stigma, poor insight, lack access health care among respondents. To address these issues, we previously developed an artificial neural network (ANN)–based classification model...
Background Research on the influence of heart failure mortality after Alzheimer's disease diagnosis is limited. Objective To evaluate association between comorbid and following diagnosis, particularly considering sex differences. Methods We analyzed administrative claims data from Japan, involving 32,363 individuals (11,064 men 21,299 women) aged 75 or older newly diagnosed with disease, 7% having failure. Cox proportional hazard models population attributable fractions (PAFs) were used to...
Objectives The objective is to clarify whether conducting a basic life support (BLS) course in the workplace enhances employees' confidence and knowledge of BLS, assess if impact diminishes for those who participate repeatedly. Methods We studied 299 manufacturing company employees attended 60-to-90-minute BLS course. Participants were divided into three groups based on number previous attendance sessions: none, one or two, more. A self-administered questionnaire was used their levels...
Highlights•Senescent cells are often pro-inflammatory and may help drive neurological disease.•Aged monkeys have increased senescence, inflammation, damage.•The senolytic navitoclax was safe in aged monkeys, with drug detectable CSF.•Navitoclax induced trends of improvement markers neuronal dysfunction.AbstractAlzheimer's disease (AD) is the most common global dementia universally fatal. Most late-stage AD disease-modifying therapies intravenous target amyloid beta (Aβ), only modest effects...
Background and Objective: Excellent generalizability is the precondition for widespread practical implementation of machine learning models. In our previous study, we developed schizophrenia classification model (SZ classifier) to identify potential patients in Japanese population. The SZ classifier has exhibited impressive performance during internal validation. However, ensuring robustness requires external validation across independent sample sets. this aimed present an using outpatient...
Several studies have shown that dairy consumption in old age is effective preventing frailty. However, there a lack of evidence regarding the association between milk during middle and development frailty age. Therefore, we carried out an investigation to explore examined after over 15 years follow up long-term cohort study Japan.
Aim Japan faces a public health challenge of dementia, further complicated by the increasing complications from diabetes within its rapidly aging population. This study assesses impact on mortality and hospitalization among individuals aged ≥75 years with new dementia diagnoses. Methods We analyzed administrative claims data in 73 324 whom 17% had comorbid diabetes. Dementia were identified International Classification Diseases, Tenth Revision codes. used Kaplan–Meier survival analysis, Cox...
To examine whether public trust was associated with the utilization of COVID-19 Contact Confirming Application (COCOA) in those who self-reported a history COVID-19. Cross-sectional study. Data were obtained from Japan Society and New Tobacco Internet Survey, nationwide online survey conducted February to March 2021, which also assessed items related trust. We included 453 participants Participants' reports their general national government policies, attitudes toward vaccination, adherence...
Abstract Objectives This study aimed to develop an approach enhance the model precision by artificial images. Materials and Methods Given epidemiological designed predict 1 response using f features with M samples, each feature was converted into a pixel certain value. Permutated these pixels F orders, resulting in distinct image sample sets. Based on experience of recognition techniques, appropriate training images results higher model. In preliminary experiment, binary predicted 76...
The aim of the present study was to derive dietary patterns explain variation in a set nutrient intakes or measurements waist circumference (WC) and fasting blood glucose (FBG) using reduced rank regression (RRR) prospectively investigate these relation risk developing metabolic syndrome (MetS) its components during follow-up. participants were comprised 2944 government employees aged 30−59 years without MetS. RRR applied with 38 food groups as predictors two sets response variables. first...
Background In Japan, challenges were reported in accurately estimating the prevalence of schizophrenia among general population. Retrieving previous studies, we investigated that patients with more likely to experience poor subjective well-being and various physical, psychiatric, social comorbidities. These factors might have great potential for precisely classifying cases order estimate prevalence. Machine learning has shown a positive impact on many fields, including epidemiology, due its...