A5083050550- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Ovarian function and disorders
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ginger and Zingiberaceae research
- Nigella sativa pharmacological applications
- Acute Myocardial Infarction Research
- Hormonal and reproductive studies
- Respiratory and Cough-Related Research
- Diabetes Treatment and Management
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Acute Kidney Injury Research
- Adenosine and Purinergic Signaling
- Phosphodiesterase function and regulation
- Regulation of Appetite and Obesity
Suez Canal University
2011-2023
University Health Network
2012
VA Salt Lake City Healthcare System
2012
National Institutes of Health
2012
National Heart Lung and Blood Institute
2012
University of Toronto
2012
Montreal Heart Institute
2010-2011
Université de Montréal
2011
Ludwig-Maximilians-Universität München
2011
McGill University
2011
cAMP is an important regulator of myocardial function, and regulation hydrolysis by cyclic nucleotide phosphodiesterases (PDEs) a critical determinant the amplitude, duration, compartmentation cAMP-mediated signaling. The role different PDE isozymes, particularly PDE3A vs PDE3B, in heart function remains unclear.
Atrial fibrillation (AF) causes atrial-tachycardia remodeling (ATR), with enhanced constitutive acetylcholine-regulated K+ current (I(KAChC)) contributing to action potential duration shortening and AF promotion. The underlying mechanisms are unknown.To evaluate the role of protein-kinase C (PKC) isoforms in ATR-induced I(KAChC) activation.Cells from ATR-dogs (400-bpm atrial pacing for 1 week) were compared control dog cells. In vitro tachypaced (TP; 3 Hz) canine cardiomyocytes parallel 1-Hz...
The glycine-tyrosine-glycine (GYG) sequence in the p-loop of K+ channel subunits lines a narrow pore through which ions pass single file intercalated by water molecules. Mutation motif can give rise to non-selective channels, but it is clear that other structural features are also required for selectivity because, instance, recently identified class cyclic nucleotide-gated pacemaker channels has GYG poorly selective. We show mutation charged glutamate and arginine residues behind filter...
In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring inhibitor and antioxidant), testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MTX has been shown induce oxidative stress exhibit antiproliferative testes. Adult rats received oral saline gavage (control group with no treatment), potential agents (LET, GSE, or Tp) alone,...
Hyperlipidemia and hypercoagulability states are linked with the increased risks of myocardial infarction (MI). Levosimendan has vasorelaxant anti-aggregatory properties. The present study evaluated cardioprotective effects levosimendan versus cilostazol in high-fat diet (HFD)-fed rats subjected to isoproterenol-induced MI. Rats were assigned normal, HFD, HFD + isoproterenol, isoproterenol cilostazol, levosimendan. investigated effect both revealed that drugs attenuated severity platelet...
Abstract Background The second-generation antipsychotics (SGAs) are a group of antipsychotic drugs, used to treat psychiatric conditions. SGAs have been shown precipitate rapid weight gain and dyslipidemia, as well promote insulin resistance, leading the emergence type 2 diabetes metabolic syndrome. Prescriptions in children increased 6- 10-fold during last decade. This research work designed find correlation between duration (SGA) use, adolescent, increase syndrome disturbance components...
The Kir3.1/Kir3.4 channel is activated by Gβγ subunits released on binding of acetylcholine to the M2 muscarinic receptor. A mechanism opening, similar that for KcsA and Shaker K+ channels, has been suggested involves translocation pore lining transmembrane helices opening an intracellular gate at "bundle crossing" region. However, in present study, we show extracellular selectivity filter critical agonist activation channel. Increasing flexibility filter, disrupting a salt bridge lies...
Cisplatin (CP) is a chemotherapy medication used to treat different types of organs cancers. It has damaging effects on testes. Mirtazapine an antidepressant, which primarily in the treatment depression and other anxiety disorders. Ginger naturally growing plant with antioxidant properties. Thirty-six adult male albino rats, subdivided into six groups (six animals each) received for 30 days. Group I (control) saline solution orally; group II mirtazapine (20 mg/kg). III ginger (200...
This study examined the effect of aromatase inhibitor letrozole (0.5 mg/kg) alone or in combination with angiotensin-receptor blocker valsartan (30 against streptozocin-induced diabetic nephropathy (DN) hypogonadal (HG) rats for 12 weeks. First, we tested HG on hormone levels, inflammatory cytokines, and oxidative stress nondiabetic (ND) (D) rats. was induced luteinizing hormone-releasing antagonist cetrorelix (0.71 mg/kg). Diabetes enhanced hormonal hypogonadism increased inflammation...
Inward rectification is caused by voltage-dependent block of the channel pore intracellular Mg2+ and polyamines such as spermine. In present study, we compared inward in Kir3.1/Kir3.4 channel, which underlies cardiac current I(K,ACh), Kir2.1 I(K,1). Sustained outward at potentials positive to K+ reversal potential was observed through Kir3.1/Kir3.4, but not Kir2.1, demonstrating that exhibits weaker than Kir2.1. We show more sensitive extracellular spermine can permeate a limited extent....
Introduction Obesity is one of the most burdensome health problems and closely linked to leptin resistance. The study examined whether an alternate-day high-fat diet (ADF) and/or GLP-1 agonist (exenatide) modulate brain resistance caused by a (HFD). Material methods Sixty adult male mice were divided into 6 groups: (i) normal palatable (NPD), (ii) exenatide control (NPD received exenatide) (iii) HFD, (iv) ADF treated, (v) (vi) treated. All animal groups fed HFD for 8 weeks, before they...
Ischemic preconditioning (Ipre) provides protection against renal ischemia-reperfusion (I/R) injury with its associated remote organ damage. This study examined the enhancing protective effect of Ipre levosimendan or cilostazol in I/R-induced kidney and lung a rat model.Rats were divided into: sham-operated, I/R control, + levosimendan. Drugs given 30 min before left 4 cycles just ischemia.The combined implemented drugs enhanced physiological antioxidant defense genes including nuclear...
Cyclophosphamide (CTX) is an effective anticancer therapy.It known to cause oxidative stress and cytotoxic effects, especially on the immune system.Pentoxifylline Nigella sativa seeds both possess antioxidant anti-inflammatory properties.This study explores ameliorative impact of pentoxifylline nigella over splenic damage induced by cyclophosphamide.Thirty-six adult male albino rats were separated into six groups from each received treatment for 10 days.Group I (control) saline 0.9% solution...
Background: AF causes atrial tachycardia remodeling (ATR), with enhanced constitutive acetylcholine regulated K + current (I KAChc ) contributing to ATR-induced APD shortening and promotion. The present study examined the mechanisms underlying I activation; based on preliminary evidence for an essential role of phosphorylation, we evaluated participation protein kinase C (PKC). Methods: Cultured dog cardiomyocytes in vitro tachypaced (TP) at 3 Hz 24 hours were compared parallel 1 paced cells...