A5033161573- Veterinary Oncology Research
- Diphtheria, Corynebacterium, and Tetanus
- Dermatology and Skin Diseases
- Clostridium difficile and Clostridium perfringens research
- Lysosomal Storage Disorders Research
- Reproductive System and Pregnancy
- Oral and Maxillofacial Pathology
- NF-κB Signaling Pathways
- Reproductive tract infections research
- Parasitic Infections and Diagnostics
- CAR-T cell therapy research
- Gastroesophageal reflux and treatments
- Oral and gingival health research
- Virus-based gene therapy research
- Helicobacter pylori-related gastroenterology studies
- Plant and fungal interactions
- Glycosylation and Glycoproteins Research
- Plant Toxicity and Pharmacological Properties
- Blood Coagulation and Thrombosis Mechanisms
- Porphyrin Metabolism and Disorders
- Parasitic Diseases Research and Treatment
- Intraocular Surgery and Lenses
- Hedgehog Signaling Pathway Studies
- Congenital Ear and Nasal Anomalies
- Neurological diseases and metabolism
Memorial Sloan Kettering Cancer Center
2022-2025
Rockefeller University
2022-2025
Cornell University
2019-2025
Weill Cornell Medicine
2022-2025
Tri-Institutional PhD Program in Chemical Biology
2022-2025
New York Hospital Queens
2023
NewYork–Presbyterian Hospital
2023
New York State College of Veterinary Medicine
2019-2021
Universidade Federal Rural do Rio de Janeiro
2016-2017
University of Minnesota
2017
Abstract Nearly half of all pregnancies are unintended; thus, existing family planning options inadequate. For men, the only choices condoms and vasectomy, most current efforts to develop new contraceptives for men impact sperm development, meaning that contraception requires months continuous pretreatment. Here, we provide proof-of-concept an innovative strategy on-demand contraception, where a man would take birth control pill shortly before sex, as needed. Soluble adenylyl cyclase (sAC)...
Chlamydia muridarum (Cm), an intracellular bacterium of historical importance, was recently rediscovered as moderately prevalent in research mouse colonies. Cm first reported a causative agent severe pneumonia mice about 80 y ago, and while it has been used experimentally to model trachomatis infection humans, there have no further reports clinical disease associated with natural infection. We observed pathology 2 genetically engi- neered (GEM) strains, Il12rb2 KO STAT1 KO, impaired...
Dystocia, a common murine reproductive condition, is classified as either obstructive, result of fetal factors such an oversized fetus, or functional, dam advanced age. Treatment based on the dam’s clinical condition and underlying etiology, but usually requires euthanasia. A prospective study was conducted to characterize etiology dystocia determine if treatment warranted. The signalment experimental, clinical, breeding histories were obtained, targeted serum chemistry panel, radiographs,...
Corynebacterium bovis (Cb), the etiologic agent of -associated hyperkeratosis (CAH) in nude mice, may impact research outcomes. Little is known about differences course and severity CAH different outbred athymic mice stocks. Three genetic stocks (designated A, B, C), 1 which was obtained from 2 geographically separate colonies with distinct microbiota (A1 A2), were inoculated topically × 10 8 cfu a pathogenic Cb field isolate (no. 7894; n = 6/stock) or sterile media ( 2/stock; controls)....
Nude mice were inoculated with a non-pathogenic Cb isolate (NPI) or Corynebacterium amycolatum (Ca) to assess whether either could prevent skin lesions following inoculation pathogenic (PI). Crl:NU(NCr)- Foxn1 nu (n=6/group) randomized into 6 groups: NPI (10 8 CFU); Ca followed 2 weeks later by PI 4 and negative positive controls receiving sterile media the CFU), respectively. Colonization was assessed biweekly using isolate-specific PCR assays. Skin scored 0 - 5 daily for at which point...
Radioimmunotherapy using 225Ac, a highly cytotoxic α-particle emitter, has potential for treating advanced breast cancer, especially human epidermal growth factor receptor 2 (HER2)-positive cases. We use pretargeted radioimmunotherapy (PRIT) approach consisting of 3-step intravenous regimen (step 1: bispecific anti-HER2/anti-DOTA antibody; step 2: clearing agent; 3: 225Ac-radiolabeled Proteus DOTA, or [225Ac]Ac-Pr). Our goal was to establish curative 225Ac-PRIT with high therapeutic indices....
Feline chronic gingivostomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflammation ulceration of the caudal oral mucosa, alveolar buccal varying degrees periodontal disease. The etiopathogenesis FCGS remains unresolved. In this study, we performed bulk RNA-seq molecular profiling affected tissues derived from cohort client-owned cats with compared to unaffected animals, identify candidate genes pathways that can help guide future exploration novel...
CLN2 disease is a fatal, childhood autosomal recessive disorder caused by mutations in ceroid lipofuscinosis type 2 (CLN2) gene, encoding tripeptidyl peptidase 1 (TPP-1). Loss of TPP-1 activity leads to accumulation storage material lysosomes and resultant neuronal cell death with neurodegeneration. Genotype/phenotype comparisons suggest that the phenotype should be ameliorated increase levels 5-10% normal wide central nervous system (CNS) distribution. Our previous clinical study showed...
Proliferation of ectopic Schwann cells within the central nervous system (CNS) parenchyma (schwannosis) in early life is most commonly associated with human neurofibromatosis type-2 and has been unrecognized domestic animals. Three foals a calf, 5 to 11 weeks old, progressive neurological signs from birth were studied. Histologically, at multiple levels spinal cord, all animals had bilateral plaques proliferative spindle cells, predominantly affecting white matter adjacent dorsal ventral...
Vaccination will likely be a key component of strategies to curtail or prevent future sarbecovirus pandemics and reduce the prevalence infection disease by SARS-CoV-2 variants. A "pan-sarbecovirus" vaccine, that provides maximum possible mitigation human disease, should elicit neutralizing antibodies with breadth. By positioning multiple different receptor binding domain (RBD) antigens in close proximity on single immunogen, it is postulated cross-reactive B cell receptors might selectively...
SOX2 is a major transcriptional regulator of stem cell pluripotency and self-renewability. Its expression in cancer cells from several different tumor types humans rodent models directly implicates tumorigenicity, metastasis, drug resistance, recurrence, poor survival. Our objective was to investigate the canine neoplasia. Immunohistochemistry for performed sets 10 archived formalin-fixed paraffin-embedded tissues 45 distinct neoplasms. Normal evaluated tissue microarray. Strong diffuse...
Abstract Fanconi anemia (FA) pathway is required for the repair of DNA interstrand crosslinks (ICL). ICLs are caused by genotoxins, such as chemotherapeutic agents or reactive aldehydes. Inappropriately repaired contribute to hematopoietic stem cell (HSC) failure and tumorigenesis. While endogenous acetaldehyde formaldehyde known induce HSC leukemia in humans with FA, effects other toxic metabolites FA pathogenesis have not been systematically investigated. Using a metabolism-focused CRISPR...
Feline chronic gingivostomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflammation ulceration of the caudal oral mucosa, alveolar buccal varying degrees periodontal disease. The etiopathogenesis FCGS remains unresolved. In this study, we performed bulk RNA-seq molecular profiling affected tissues derived from cohort client-owned cats with compared to unaffected animals, identify candidate genes pathways that can help guide future exploration novel...
ABSTRACT: Canine transmissible venereal tumor (CTVT) is a naturally occurring contagious round-cell neoplasia, with poorly understood origin and transmission. This study aims to further investigate the nature through immunohistochemistry, lectin histochemistry transmission electron microscopy (TEM) analysis, provide support for diagnostic differential diagnoses of CTVT. Immunohistochemistry was performed in 10 genital six exclusively extragenital tumors, which were previously diagnosed by...
espanolObjetivo: Identificar los factores de riesgo VRP, la incidencia y el momento aparicion esta complicacion en una serie prospectiva desprendimientos retina regmatogenos (DR). Metodos: Se ha realizado un estudio multicentrico prospectivo 223 casos DR. han incluido 83 variables referentes a caracteristicas preoperatorias, intraoperatorias postquirurgicas. efectuado analisis regresion logistica. Resultados: De DR, 22 desarrollaron VRP (incidencia 9,9%, intervalo confianza al 95%:...
Mucociliary clearance is a main defense mechanism of the respiratory tract, which can be inherently impaired in primary ciliary dyskinesia (PCD) or reversibly altered secondary (SCD). Limited diagnostic test availability likely leads to misdiagnosis underdiagnosis PCD animals. This study evaluated light and transmission electron microscopy (TEM) changes mucosa 15 dogs with chronic disease suspected PCD. Necropsy was performed 1 case 2 were used as negative controls. confirmed dog, presented...
Corynebacterium bovis (Cb), the cause of hyperkeratotic dermatitis in various immunocompromised mouse strains, significantly impacts research outcomes if infected mice are used. Although Cb has been isolated from a variety species, including mice, rats, cows, and humans, little is known about differences infectivity clinical disease that associated with specific isolates. The infectious dose colonized 50% exposed population (ID 50 ) any was determined athymic nude (Hsd:Athymic Nude-Foxn1 nu...
Abstract Corynebacterium bovis (Cb), the etiology of -associated hyperkeratosis (CAH) in nude mice, may impact research outcomes. Little is known about differences course and severity CAH different outbred athymic mice stocks. Three genetic stocks (designated A, B, C), 1 which was obtained from 2 geographically separate colonies with distinct microbiota (A1 A2), were inoculated topically × 10 8 CFUs a pathogenic Cb field isolate (#7894; n = 6/stock) or sterile media (n=2/stock; controls)....
Chlamydia muridarum (Cm), an intracellular bacterium of historical importance, was recently rediscovered as moderately prevalent in research mouse colonies. Cm first reported a causative agent severe pneumonia mice about 80 y ago, and while it has been used experimentally to model trachomatis infection humans, there have no further reports clinical disease associated with natural infection. We observed pathology 2 genetically engineered (GEM) strains, Il12rb2 KO STAT1 KO, impaired...