A5103487462- Theoretical and Computational Physics
- Stochastic processes and statistical mechanics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- RNA and protein synthesis mechanisms
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- RNA Research and Splicing
- Pneumocystis jirovecii pneumonia detection and treatment
- Diffusion and Search Dynamics
- Protein Structure and Dynamics
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Cytomegalovirus and herpesvirus research
- Neonatal Respiratory Health Research
- Complex Network Analysis Techniques
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Antifungal resistance and susceptibility
- Genomics and Chromatin Dynamics
- Nosocomial Infections in ICU
- Respiratory viral infections research
Tallinn University
2021-2025
University of Basel
1997-2025
Hospital Base
2017-2024
University Hospital of Basel
2012-2023
King's College London
2023
Lomonosov Moscow State University
2013-2022
National Research University Higher School of Economics
2014-2021
Moscow State Institute of Electronics and Mathematics
2020
Moscow State University
2012-2020
A. N. Nesmeyanov Institute of Organoelement Compounds
2002-2015
In patients with ventilator-associated pneumonia (VAP), guidelines recommend antibiotic therapy adjustment according to microbiology results after 72 h. Circulating procalcitonin levels may provide evidence that facilitates the reduction of therapy. a multicentre, randomised, controlled trial, 101 VAP were assigned an discontinuation strategy (control group) or serum concentrations (procalcitonin regimen selected by treating physician. The primary end-point was antibiotic-free days alive...
Exercise testing with measurement of maximal oxygen uptake (VO2max) is increasingly used in the assessment lung resection candidates, but its predictive value for postoperative complications remains controversial. We therefore sought to determine prognostic VO2max compared other pulmonary function tests. A consecutive group 80 patients (mean age 61 yr; 57 males and 23 females) scheduled (62 malignancies, 12 benign disorders, 6 carcinoids) underwent tests symptom-limited cycle ergometry. All...
Vascular endothelial growth factor (VEGF) is a potent peptide specific for vascular cells, which promotes neovascularization and increases permeability in vivo. Enhanced microvascular edema are common characteristics of inflammatory neoplastic disorders. Two proinflammatory mediators, platelet-activating (PAF) platelet-derived (PDGF), known to contribute cellular damage tissue remodeling number lung diseases. To determine whether PAF or PDGF induce VEGF gene expression primary cultures human...
The influence of pulmonary resection on functional capacity can be assessed in different ways. aim this study was to compare the effect lobectomy and pneumonectomy function tests (PFT), exercise perception symptoms. Sixty eight patients underwent assessment with PFT testing before (Preop), 3 6 months after lung resection. In 50 (36 males 14 females; mean age 61 yrs) a performed 18 (13 5 59 performed. Three lobectomy, forced vital (FVC), expiratory volume one second (FEV1), total (TLC),...
Abstract Background Vasopressin has haemodynamic as well osmoregulatory effects, and reflects the individual stress response. Copeptin is cosynthesized with vasopressin, directly mirroring vasopressin levels, but more stable in plasma serum. Both levels are increased patients septic shock. Lower respiratory tract infections (LRTI) a precursor of sepsis. Thus, we investigated circulating prognostic use copeptin for severity outcome LRTI. Materials methods Five hundred forty‐five consecutive...
The fractal globule state is a popular model for describing chromatin packing in eukaryotic nuclei. Here we provide scaling theory and dissipative particle dynamics computer simulation the thermal motion of monomers state. Simulations starting from different entanglement-free initial states show good convergence which provides evidence supporting existence unique metastable We monomer this to be subdiffusive described by ⟨X(2)(t)⟩∼t(αF) with αF close 0.4. This result agreement existing...
Given the internationally recognized definition of bronchiolitis obliterans syndrome (BOS) and longer follow up heart-lung transplant recipients, it is possible to establish some major risk factors for development progression BOS. Between April 1984 31 December 1993, 157 patients underwent transplantation; 126 survived at least six months after operation so were developing The following early assessed BOS grade 1 (21-35% decline in FEV1) from 2 (36-50% FEV1): age, gender underlying diagnosis...
Combined sedation with a benzodiazepine and an opiate has been proposed as standard for bronchoscopy. Propofol is sedative–hypnotic rapid onset of action fast recovery time, but carries the potential risk respiratory failure. Consecutive patients (n = 200) were randomly allocated to receive either combination midazolam hydrocodone or intravenous propofol. The primary end-points mean lowest arterial oxygen saturation during bronchoscopy readiness-for-discharge score 1 h after procedure. did...
In this article, we investigate the effect of hydrocarbon addition on rheological properties and structure wormlike micellar solutions potassium oleate. We show that a viscoelastic solution entangled chains is extremely responsive to hydrocarbons—the only 0.5 wt % n-dodecane results in drastic drop viscosity by up 5 orders magnitude, which due complete disruption micelles formation microemulsion droplets. study whole range transition into droplets discover it can be divided three regions:...
Chromosomes are key players of cell physiology, their dynamics provides valuable information about its physical organization. In both prokaryotes and eukaryotes, the short-time motion chromosomal loci has been described with a Rouse model in simple or viscoelastic medium. However, little emphasis put on influence folded organization chromosomes local dynamics. Clearly, stress propagation, thus dynamics, must be affected by such organization, but theory allowing us to extract from data, e.g.,...
Community-acquired pneumonia (CAP) is the leading infectious cause of death in developed countries. Risk stratification has previously been difficult.Markers cardiac stress (B-type natriuretic peptide, BNP) and inflammation (C-reactive protein, white blood cell count, procalcitonin) as well severity index (PSI) were determined 302 consecutive patients presenting to emergency department (ED) with CAP. The accuracy these parameters predict was evaluated primary endpoint. Prediction treatment...
The antipsoriatic dimethylfumarate (DMF) has been anecdotically reported to reduce asthma symptoms and improve quality of life patients. DMF decreases the expression proinflammatory mediators by inhibiting transcription factor NF-kappaB might therefore be interest for therapy inflammatory lung diseases. In this study, we determined effect on platelet-derived growth (PDGF)-BB- TNFalpha-induced asthma-relevant cytokines activation primary human asthmatic nonasthmatic airway smooth muscle cells...
In patients with community-acquired pneumonia (CAP) prediction rules based on individual predicted mortalities are frequently used to support decision-making for in-patient vs. outpatient management. We studied the accuracy and need recalibration of three risk scores in a tertiary-care University hospital emergency-department setting Switzerland. pooled data from CAP enrolled two randomized controlled trials. compared expected mortality original severity index (PSI), CURB65 CRB65 against...
ObjectivesNosocomial Pseudomonas aeruginosa pneumonia remains a major concern in critically ill patients. We explored the potential impact of microorganism-targeted adjunctive immunotherapy such
We consider the canonical ensemble of N-vertex Erdős-Rényi (ER) random topological graphs with quenched vertex degree, and fugacity μ for each closed triple bonds. claim complete defragmentation large-N into collection [p^{-1}] almost full subgraphs (cliques) above critical fugacity, μ_{c}, where p is ER bond formation probability. Evolution spectral density, ρ(λ), adjacency matrix increasing leads to a multizonal support μ>μ_{c}. Eigenvalue tunneling from central zone side one means new...
The functional relevance of interleukin 6 (IL-6) in platelet-derived growth factor (PDGF)-induced cell was evaluated cultures human fibroblasts, vascular smooth muscle cells, and mesangial cells. three isoforms the PDGF--namely, PDGF-AA, -AB, -BB--induced expression IL-6 gene proliferation nontransformed PDGF-induced transcription, translation, secretion were diminished presence antisense oligonucleotides. While neutralizing anti-IL-6 antibodies failed to affect factor-dependent...
Platelet-activating factor (PAF) is a potent proinflammatory phospholipid mediator of the lung. In this study, we demonstrate that PAF receptor mRNA and protein expressed by human lung fibroblasts. Interaction with its specific resulted in increases tyrosine phosphorylation several intracellular proteins, indicating PAF-receptor might be functionally active. PAF-induced transcription protooncogenes c-fos c-jun as well interleukin (IL)-6 IL-8 genes Transcription interleukins was followed...
The aim of the present study was to evaluate long-term outcome patients with primary spontaneous pneumothorax treated talc pleurodesis. A follow-up undertaken in all who underwent pleurodesis for prolonged air leak or recurrence using thoracoscopy. In total, 112 and data obtained 63 (56%) patients: 45 were available clinical follow-up, 14 telephone four dead. causes death unrelated There no episodes acute respiratory failure following total 56 (95%) out cohort 59 had a successful Surgical...
Propofol and the combination of a benzodiazepine an opiate have been established for sedation in flexible bronchoscopy. It is as yet unknown whether propofol with superior to alone suppress cough during procedure. 300 consecutive patients undergoing bronchoscopy at tertiary care university hospital were randomly allocated receive either hydrocodone or double-blind fashion. The primary end-point was score procedure estimated by physician using visual analogue scale. Demographics similar both...
<i>Background:</i> Impaired nasal breathing is a risk factor for obstructive sleep apnea syndrome (OSAS). <i>Objectives: </i>The aim of this study was to determine whether atopy perennial allergens and existence allergic rhinitis OSAS. <i>Methods:</i> In case-control study, we compared the proportions OSAS patients with in chronic pulmonary disease (COPD). Seventy-two (mean age 60.7 years; 79.4% male) 44 COPD 63.6 88.6% were selected from hospital...
Abstract: Infectious complications are frequent following lung transplantation. Tracheobronchial aspergillosis is the predominant fungal infection in these patients. Infections with Scedosporium apiospermium (Pseudoallescheria boydii) and prolificans (Scedosporium inflatum) have mainly been described bone marrow transplant recipients only occasionally solid organ recipients. We analysed risk factors, clinical course outcome of seven who developed pulmonary scedosporium infection. was...