A5035208784- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Multiple and Secondary Primary Cancers
- Systemic Lupus Erythematosus Research
- FOXO transcription factor regulation
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Rheumatoid Arthritis Research and Therapies
- Cancer-related Molecular Pathways
- Hedgehog Signaling Pathway Studies
- Cancer Genomics and Diagnostics
- TGF-β signaling in diseases
- Cancer Diagnosis and Treatment
- Seaweed-derived Bioactive Compounds
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
Instituto de investigación sanitaria y biomédica de Alicante
2021-2024
Hospital General Universitario de Alicante Doctor Balmis
2020-2023
Hospital Universitario Virgen de las Nieves
2021
Abstract Oxidative stress has been linked to the onset and progression of different neoplasia. Antioxidants might help prevent it by modulating biochemical processes involved in cell proliferation. Here, aim was evaluate vitro cytotoxic effect Haloferax mediterranei bacterioruberin-rich carotenoid extracts (BRCE) (0–100 µg/ml) six BC lines, representative intrinsic phenotypes a healthy mammary epithelium line. Cell index values were obtained using xCELLigence RTCA System. Furthermore,...
Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are the most frequently used rheumatoid arthritis (RA) diagnostic markers, but they unable to anticipate patient's evolution or response treatment. The aim of this study was identify possible severity biomarkers predict an upcoming flare-up remission period. To address objective, sera anticoagulated blood samples were collected from healthy controls (HCs; n = 39) early RA (n 10), 5), 16) patients. We analyzed leukocyte...
Purpose. Previous studies have shown that melanoma cells produce excessive levels of cytokines, which various biological roles during development. The aim this study was to expand the profile serum chemokines, growth factors, and angiogenic factors are associated with melanoma, find more cytokines abnormal concentrations in patients, identify whether level correlated prognostic variants, such as Breslow thickness BRAF mutation, and, finally, out play important Materials Methods. Multiplex...
Advances in immunotherapy have increased interest knowing the role of immune system breast cancer (BC) pathogenesis. Therefore, checkpoints (IC) and other pathways related to regulation, such as JAK2 FoXO1, emerged potential targets for BC treatment. However, their intrinsic gene expression vitro has not been extensively studied this neoplasia. Thus, we evaluated mRNA tumor-cell-intrinsic
Inhibitor of differentiation (ID) proteins are a family transcription factors that contribute to maintaining proliferation during embryogenesis as they avoid cell differentiation. Afterward, their expression is mainly silenced, but reactivation and contribution tumor development have been suggested. In breast cancer (BC), the overexpression ID1 has previously described. However, whether remaining ID genes specific role in this neoplasia still unclear. We studied mRNA all by q RT-PCR BC lines...
The influence of HLA class I and II loci on the susceptibility to melanoma remains an area intense debate. This study aimed examine whether system was related prognosis in a southern Spanish population. In this study, genotyping were performed using polymerase chain reaction sequence-specific oligonucleotides (PCR-SSO) 237 patients 636 ethnically matched controls. Data analyzed according clinical characteristics defined subgroups. Compared control group, DRB1∗16:01 (4% vs. 1.3%, p=0.001, Pc...
Abstract Melanoma is one of the most aggressive forms human cancer and its incidence has significantly increased worldwide over last decades. This neoplasia been characterized by release a wide variety soluble factors, which could stimulate tumor cell proliferation survival in an autocrine paracrine manner. Consequently, we sought to evaluate pattern factors produced pre-metastatic metastatic melanoma established cultures, determine whether these can be detected autologous serum malignant...
Recent evidence support that the immune system has both positive and negative effects on tumorigenesis. Systemic inflammation been linked to aggressive tumor growth, metastasis, drug resistance in breast cancer (BC) patients. Therefore, serum cytokines (SC) may represent an exciting biomarker monitoring of BC pathogenesis. Pretreatment from 204 patients (23% Luminal A, 23.6% B/HER2-, 22.5% B/HER2+, 10.3% HER2-enriched, 20.6% Triple-Negative/Basal-like -TNBL-) 50 healthy donors was collected....
Abstract Background Breast cancer (BC) is the most common in women and leading cause of cancer-related death worldwide. This heterogeneous disease has been historically considered a non-immunogenic type cancer. However, recent advances immunotherapy have increased interest knowing role immune checkpoints (IC) other regulation pathways this neoplasia. Methods In retrospective study, we evaluated correlation mRNA expression CTLA-4, PDCD1 (PD1), CD274 (PD-L1), PDCD1LG2 (PD-L2), CD276 (B7-H3),...
Breast cancer (BC) is the most common in women and leading cause of cancer-related death worldwide. This heterogeneous disease has been historically considered a non-immunogenic type cancer. However, recent advances immunotherapy have increased interest knowing role immune checkpoints (IC) this neoplasia. Thus, we analyzed mRNA expression CTLA-4, PDCD1 (PD1), CD274 (PD-L1), PDCD1LG2 (PD-L2) evaluated correlation with clinicopathological factors patient outcome. We included 275...
Breast cancer (BC) is the most common in women and leading cause of cancer-related death worldwide. This heterogeneous disease has been historically considered a non-immunogenic type cancer. However, recent advances immunotherapy have increased interest knowing role immune checkpoints (IC) other regulation pathways this neoplasia.
<h3>Background</h3> Immune checkpoint inhibitors (ICIs), by activating the immune system (specifically, T-cells), foster reaction against tumor cells. However, parallelly, autoimmune phenomena, known as immune-related adverse effects (ir-AEs) (PMID 33902919, 29442540), can be triggered and manifest in any organ or tissue. The most common rheumatic manifestations are inflammatory arthritis, polymyalgia rheumatica, myositis, but other cases have also been described 32403289). More data on...