A5053675818- Complement system in diseases
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Congenital Heart Disease Studies
- Pain Management and Opioid Use
- Liver Disease and Transplantation
- T-cell and B-cell Immunology
- Congenital heart defects research
- Congenital gastrointestinal and neural anomalies
- Bone and Joint Diseases
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Genetic Mapping and Diversity in Plants and Animals
- Opioid Use Disorder Treatment
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Clinical Nutrition and Gastroenterology
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Musculoskeletal pain and rehabilitation
Duke University Health System
2024
UConn Health
2017-2023
Gynecologic Oncology Group
2023
Jackson Laboratory
2017-2019
APT Foundation
2018
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2013
Oregon Health & Science University
2012
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef directs escape from immune surveillance by subverting host cell intracellular signaling and membrane traffic to down-regulate cell-surface major histocompatibility complex class I (MHC-I). interaction of with the sorting proteins PACS-1 PACS-2 mediates key trafficking steps required for Nef-mediated MHC-I down-regulation. Little is known, however, about molecular basis underlying Nef-PACS interaction. Here we identify...
Molecular mechanisms remain unknown for most type 2 diabetes genome-wide association study identified loci. Variants associated with and fasting glucose levels reside in introns of ADCY5, a gene that encodes adenylate cyclase 5. Adenylate 5 catalyzes the production cyclic AMP, which is second messenger molecule involved cell signaling pancreatic β-cell insulin secretion. We demonstrated risk alleles are decreased ADCY5 expression human islets examined candidate variants regulatory function....
To determine whether HLA-B27 expression alters the response of bone marrow monocytes from HLA-B27/human β2 -microglobulin-transgenic (B27-Tg) rats to tumor necrosis factor α (TNFα) and, if so, this affects cells involved in homeostasis.Bone were treated with RANKL or TNFα promote osteoclast formation. Osteoclasts quantified by counting. Gene was measured using quantitative polymerase chain reaction analysis, and protein detected enzyme-linked immunosorbent assay, immunoblotting,...
Background Despite high rates of chronic pain among their patients, opioid agonist treatment (OAT) counselors report an absence training to manage pain. Methods A multidisciplinary team developed a tailored for screen and address via brief psychosocial intervention, implemented it with 52 addiction counselors. Data on knowledge (9 true-false items) as well attitudes, interest, perceived ability (scored 5-point Likert-type scales) were collected from before (pre-test), after (post-test)...