A5101915724- Viral Infections and Immunology Research
- Circular RNAs in diseases
- Plant responses to water stress
- Genomics, phytochemicals, and oxidative stress
- Plant Stress Responses and Tolerance
- Cardiac Fibrosis and Remodeling
- Pluripotent Stem Cells Research
- Plant nutrient uptake and metabolism
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Soybean genetics and cultivation
- IL-33, ST2, and ILC Pathways
- Pancreatic function and diabetes
- RNA regulation and disease
- Extracellular vesicles in disease
- Cytomegalovirus and herpesvirus research
Dalian Medical University
2025
Jilin University
2018-2023
Union Hospital
2018-2023
Peking University
2008
Emerging evidence closely links Enterovirus 71 (EV71) infection with the generation of reactive oxygen species (ROS). Excess ROS results in apoptosis and exacerbates inflammatory reactions. The Keap1-Nrf2 axis serves as an essential oxidant counteracting pathway.The present study aimed to elucidate role pathway modulating reactions triggered by oxidative stress Vero RD cells upon EV71 infection.Elevated production was identified infected cells. percentage dead expression...
Abstract Several studies have substantiated the correlation between reactive oxygen species (ROS) and Sirtuin 1 (SIRT1). Normally, enterovirus 71 (EV71) is associated with severe clinical manifestations death. However, effect of EV71 on induction cellular death interplay ROS/SIRT1 in cell has not been confirmed yet. In current study, an increase number apoptotic cells was observed as soon infection initiated mice. Furthermore, also promoted a rise levels three commonly known proinflammatory...
Accumulating evidence has shown that microRNA (miR) derived from M1 macrophage-derived exosomes can regulate the progression of hepatocellular carcinoma (HCC). However, effect miR-326 on HCC not been reported. Therefore, objective present study was to explore mechanism exosomal macrophages in regulating cell progression. RT-qPCR detected expression lines. altered by transfection, and CD206 NF-κB expression, proliferation, colony formation, migration, apoptosis invasion detected....
Despite advancements in the development of targeted approaches for treatment myocardial infarction (MI), there is a continuing need improvements due to high mortality and prevalence MI. The identification specific therapeutic targets efficient delivery systems are essential. In this study, nanoparticle system targeting necrotic cardiomyocytes was engineered. This effectively downregulated long noncoding RNA (lncRNA) AK156373 reduced oxidative stress inflammation during MI progression....