A5046975655- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Male Breast Health Studies
- Kruppel-like factors research
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Myasthenia Gravis and Thymoma
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Cutaneous Melanoma Detection and Management
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Urinary and Genital Oncology Studies
- Genetic factors in colorectal cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
University of Turin
2012-2021
Candiolo Cancer Institute
2018
Geisinger Medical Center
2008
Cancer Institute (WIA)
2008
Cairo University
2008
Stanford University
2008
Stanford Medicine
2008
Medizinische Hochschule Hannover
2005
Ospedale San Giovanni Bosco
2000
Azienda Ospedaliero Universitaria San Giovanni Battista
1997-1998
Objective: Even though diagnostic oral exfoliative cytology is a useful, economical and practical tool in the diagnosis of dysplasia carcinoma, it not yet extensively used. The results conventional liquid‐based potentially malignant lesions (PML) are herein reported compared with histological diagnosis. Methods: Either (89) or (384) was used for dysplasia/carcinoma 473 subjects were scalpel biopsy histology. Cells collected using Cytobrush device smears dermatological curette cytology....
PURPOSE: To investigate the prognostic value of biomarkers in male breast carcinoma (MBC). PATIENTS AND METHODS: Fifty patients (mean age, 62.2 years) with invasive ductal were retrospectively studied. All received surgery; 35 had adjuvant postoperative therapy. The median follow-up was 59 months (range, 1 to 230 months). c-myc, c-erbB-2, p53, and bcl-2 proteins immunohistochemically detected on sections from formalin-fixed, paraffin-embedded tissues using 9E11, CB11, DO7, 124 monoclonal...
To verify the correlation between MIB-1, Ki67, and proliferating cell nuclear antigen (PCNA-PC10) scores S-phase fraction in intermediate grade non-Hodgkin's lymphomas (Working Formulation F); their reliability differently processed tissues.Forty one were classified as (F) malignant according to Working Formulation; mitotic counts percentage of large cells assessed for each case. Sections from formalin fixed, paraffin wax embedded tissues stained with anti MIB-1 monoclonal antibody, after...
Recurrence of transitional cell carcinoma the bladder cannot be predicted accurately by traditional criteria alone. This study examined value proliferative activity, morphometry, and expression p53, c-erbB-2, bcl-2 oncogenes in predicting recurrence superficial papillary urothelial neoplasms low malignant potential (LMP) Grade 1 (G1) carcinomas bladder.Sixty-two patients (mean age, 62 years) with newly diagnosed pTa tumors (19 LMP, 43 G1) were analyzed retrospectively. All underwent...
Androgen receptor (AR) expression was retrospectively analysed in 47 primary male breast carcinomas (MBCs) using a monoclonal antibody on formalin-fixed, paraffin-embedded tissues. AR immunopositivity detected 16 out of (34%) cases. No association found with patient age, tumour stage, progesterone (PGR) or p53 protein expression. Well-differentiated MBCs tended to be positive more often than poorly differentiated ones (P= 0.08). A negative between ARs and cell proliferative activity: MIB-1...
Background: Chronic myelomonocytic leukaemia (CMML) is a haematopoietic malignancy with heterogeneous clinical and morphological features. It classified in the World Health Organization myeloproliferative-myelodysplastic overlap category. JAK2 V617F mutation can be found large percentage of patients myeloproliferative neoplasms. Aims: To investigate association between clinical, haematological bone marrow histological features CMML to verify whether associated type disease. Methods: 78...
Lobular carcinoma of the breast has been studied using histochemical methods for mucosubstances; immunocytochemical casein and actin; ruthenium red electronycytochemical method acid glycoproteins an immunoelectroncytochemical casein. Mucosubstances showed a similar cytoplasmic localization, but production was much more intense also diffuse localization. Occasionally assumed form target-like 'inclusions' as seen characteristically with mucosubstances. The neoplastic cells were not stained by...
We investigated the expression of oncogenes p53, c-erbB-2, and bcl-2 cell proliferative activity in 62 newly diagnosed superficial pTa papillary bladder tumors. Based on 1998 World Health Organization/International Society Urological Pathology (WHO/ISUP) 1999 WHO classifications, 19 were urothelial neoplasias low malignant potential (LMP) 43 low-grade (grade 1) carcinomas. All patients underwent transurethral resection followed up to 97 months; 42 had recurrences. Initial biopsies tested for...
Background: Malignant cellular blue nevus (MCBN) is a rare entity due to the malignant transformation of preexisting (CBN). Objective and Methods: The clinical pathologic features 6 patients with MCBN are described. Results: Three tumors were located on scalp, 2 trunk 1 neck. lesions, present from birth or childhood, had enlarged rapidly in last months before excision. Histologically, there was dermal proliferation spindle epithelioid atypical melanocytic cells. Some them heavily pigmented....
By means of specific immunochemical methods, material reacting with anti-human casein antisera has been detected in various human tissues and mainly ductules the breast, sebaceous sweat glands skin, bronchial epithelium glands, at surface some alveoli lung, exocrine pancreas, endometrium proliferative phase distal collecting tubules kidney. The exact chemical nature physiological significance proteins present extramammary sites anti-casein antibodies are not clear; it appears, however, that...
The American Society of Clinical Oncology/College Pathologists (ASCO/CAP) 2013 guidelines for HER2 assessment have increased the number equivocal breast carcinomas following in situ hybridization reflex testing, that is, "double equivocal" (equivocal protein expression and gene copy number). Forty-five double-equivocal were subjected to Prosigna analysis. Twenty-seven cases investigated genes found be differentially expressed between estrogen receptor (ER)-positive/HER2-positive (N=22)...