A5046546837- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Cancer Cells and Metastasis
- Soft tissue tumor case studies
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
Hôpital Nord
2020-2024
Aix-Marseille Université
2019-2023
Centre de Recherche en Cancérologie de Marseille
2023
Inserm
2023
Centre National de la Recherche Scientifique
2023
Assistance Publique Hôpitaux de Marseille
2020
Abstract Background The prognosis of patients with pancreatic cancer remains poor and novel therapeutic targets are required urgently. Treatment resistance could be due to the tumour microenvironment, a desmoplastic stroma consisting cancer-associated fibroblasts tumour-infiltrating lymphocytes (TILs). aim study was evaluate prognostic value TILs (CAFs) in body tail. Methods Using tissue microarray from resected left-sided specimens, immunohistochemistry (cluster differentiation (CD) 45,...
Hepatocellular carcinoma (HCC) is a frequent and deadly cancer in need of new treatments. Immunotherapy has shown promising results several solid tumors. The TIGIT/DNAM-1 axis gathers targets for immune checkpoint inhibitors (ICIs). Here, we aimed at highlighting the potential this as therapeutic option HCC. For this, built large transcriptomic database 683 HCC samples, clinically annotated, 319 normal liver tissues. We interrogated expression each member tested their prognostic value...