A5046647190- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Stress Responses and Cortisol
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Autoimmune and Inflammatory Disorders Research
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Digestive system and related health
- Genetics, Bioinformatics, and Biomedical Research
- Protein purification and stability
- Neuropeptides and Animal Physiology
- Healthcare and Venom Research
- Rheumatoid Arthritis Research and Therapies
- Psychosomatic Disorders and Their Treatments
- Tissue Engineering and Regenerative Medicine
- Quality and Safety in Healthcare
- T-cell and B-cell Immunology
- Neuroendocrine regulation and behavior
- Neonatal Respiratory Health Research
- Music Therapy and Health
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
Analog Devices (United States)
2024
University College London
2020-2021
Queen Mary University of London
2013-2020
William Harvey Research Institute
2013-2020
Abstract An imbalanced immune system has long been known to influence a variety of mood disorders including anxiety, obsessive-compulsive and depression. In this study, we sought model the impact an immunocompromised state on these emotional behaviors using RAG-1 −/− mice, which lack T B cells. We also investigated relative contribution CD4 + or CD8 cells manifestations /OT-II /OT-I transgenic respectively. Our results show that mice present significant increase in digging marble-burying...
Formyl peptide receptors (FPR) belong to a family of sensors the immune system that detect microbe-associated molecules and inform various cellular sensorial mechanisms presence pathogens in host. Here we demonstrate Fpr2/3-deficient mice show distinct profile behaviour characterised by reduced anxiety marble burying light-dark box paradigms, increased exploratory an open-field, together with superior performance on novel object recognition test. Pharmacological blockade formyl receptor...
T cells are known to be plastic and change their phenotype according the cellular biochemical milieu they embedded in. In this study we transposed concept at a macroscopic level assessing whether changes in environmental housing conditions of C57/BL6 mice would influence function cells. Our shows that exposure two weeks an enriched environment does not impact cell repertoire vivo causes no early TCR-driven activation events these Surprisingly, however, from showed unique helper effector-cell...
Pompe disease is a lysosomal storage disorder caused by malfunctions of the acid alpha-glucosidase (GAA) enzyme with consequent toxic accumulation glycogen in cells. Muscle wasting and hypertrophic cardiomyopathy are most common clinical signs that can lead to cardiac respiratory failure within first year age more severe infantile forms. Currently available treatments have significant limitations not curative, highlighting need for development alternative therapies. In this study, we...
Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given emerging role T cells in controlling both emotions and autoimmunity, this study we explored possible correlation between cell activation changes behavior a mouse model sclerosis. Our results showed significant increase blood circulating as soon at day 4 post-immunization. This lymphocytosis remained stable time...
Chronic granulomatous disease (CGD) is an inherited blood disorder of phagocytic cells that renders patients susceptible to infections and inflammation. A recent clinical trial lentiviral gene therapy for the most frequent form CGD, X-linked, has demonstrated stable correction over time, with no adverse events related procedure. We have recently developed a parallel vector p47phox-deficient CGD (p47phoxCGD), second common this disease. Using vector, we observed biochemical in mouse model In...
Abstract Patients suffering from autoimmune diseases are more susceptible to mental disorders yet, the existence of specific cellular and molecular mechanisms behind co-morbidity these pathologies is far being fully elucidated. By generating transgenic mice overexpressing Annexin-A1 exclusively in T cells study its impact models diseases, we made unpredicted observation an increased level anxiety. Gene microarray CD4 + identified a novel anxiogenic factor, small protein approximately 21kDa...