A5048704268- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Oral and gingival health research
- Fibroblast Growth Factor Research
- Cellular transport and secretion
- Hypothalamic control of reproductive hormones
- Cerebrospinal fluid and hydrocephalus
- Circadian rhythm and melatonin
- Ophthalmology and Eye Disorders
- Growth Hormone and Insulin-like Growth Factors
- Veterinary Pharmacology and Anesthesia
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Body Composition Measurement Techniques
- Kruppel-like factors research
- Coronary Artery Anomalies
- Cardiovascular Conditions and Treatments
Seoul National University
2010-2024
Jeju National University
2024
Kunming Medical University
2020
Johns Hopkins Medicine
2006-2017
Johns Hopkins University
2006-2017
Soonchunhyang University
2013
Korea National Sport University
2010
Angiogenesis Foundation
2006
University of Michigan
2006
Metabolism Without Modification Obesity-associated metabolic disease has rapidly become a public health priority in the developed world and is being addressed through prevention strategies aimed at lifestyle changes pharmacological approaches. Barnett et al. (p. 1689 , published online 18 November) designed drug that inhibits action of ghrelin, circulating peptide hormone increases fat mass food intake. The drug, bisubstrate analog called GO-CoA-Tat, selective antagonist ghrelin...
Previous studies using in vitro cell culture systems have shown the role of dynamin-related GTPase Opa1 apoptosis prevention and mitochondrial DNA (mtDNA) maintenance. However, it remains to be tested whether these functions are physiologically important vivo mammals. Here, Cre-loxP system, we deleted mouse pancreatic beta cells, which glucose-stimulated ATP production mitochondria plays a key insulin secretion. Beta cells lacking maintained normal copy numbers mtDNA; however, amount...
Beta-cell proliferation is an important mechanism underlying beta-cell mass adaptation to metabolic demands. We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation beta-cells.Changes islet protein levels cyclins and two critical regulators cyclin kinase inhibitor p27 S-phase kinase-associated 2 (Skp2) were assessed mice treated with a mouse model specific upregulation nuclear signaling...
The cyclic AMP (cAMP) signaling pathway is central in β-cell gene expression and function. In the nucleus, protein kinase A (PKA) phosphorylates CREB, resulting recruitment of transcriptional coactivators p300 CREB binding (CBP). CBP, but not p300, phosphorylated at serine 436 response to insulin action. CBP phosphorylation disrupts CREB-CBP interaction thus reduces nuclear cAMP To elucidate importance cAMP-PKA-CREB-CBP pancreatic β cells specifically level, we have examined mutant mice...
Summary Objective A relationship between visceral fat accumulation and metabolic syndrome (MetS) has been established. However, the effect of a relative increase in decrease muscle mass on disorders not investigated. The aim present study was to examine association ratio thigh area (VMR) MetS Korean adults. Study subject/measurements total 264 age‐and gender‐matched subjects recruited from Sarcopenic Obesity (KSOS), an ongoing prospective observational cohort study, were categorized into...
Incretin hormone action on β-cells stimulates in parallel two different intracellular cyclic AMP-dependent signaling branches mediated by protein kinase A and exchange activated cAMP islet/brain isoform 2A (EPAC2A). Both pathways contribute toward potentiation of glucose-stimulated insulin secretion (GSIS). However, the overall functional role EPAC2A as it relates to vivo glucose homeostasis remains incompletely understood. Therefore, we have examined GSIS global knockout mice. Additionally,...
We present a fluorescent-PCR-based technique to assay genomic sequence copy number and transcriptional abundance. This relies on the ability follow fluorescent PCR progressively in real time during exponential phase of reaction so that quantitative is accomplished. demonstrated this quantitate both known deletions amplifications loci have been measured previously by other methods, measure Using an efficient variant fluorescent-PCR technology, we can monitor transcription semiquantitatively....
Carney complex (CNC) is a rare disease associated with multiple neoplasias, including predisposition to pancreatic tumors; it caused most frequently by the inactivation of PRKAR1A gene, regulator cyclic AMP (cAMP)-dependent kinase (PKA). The method used was create null alleles prkar1a in mouse cells expressing pdx1 (Δ-Prkar1a). We found that these mice developed endocrine or mixed endocrine/acinar cell carcinomas 100% penetrance age 4-5 months. Malignant behavior tumors seen as evidenced...
Parasympathetic nervous system (PNS) innervates with several peripheral organs such as liver, pancreas and regulates energy metabolism. However, the direct role of PNS on food intake has been poorly understood. In present study, we investigated parasympathetic in regulation feeding by chemogenetic methods. Adeno associated virus carrying DREADD (designer receptors exclusively activated designer drugs) infused into target brain region stereotaxic surgery. The stimulatory hM3Dq or inhibitory...
Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency, subsequent to both reduced β-cell mass and insufficient secretion, augmenting function are therapeutic strategies for treating T2DM. However, the significance of increasing vs improving stimulus secretion coupling remains unclear. We have developed a mouse model that allows proliferation β-cells in adult mice without affecting inducible expression positive cell cycle regulator cyclin A2 specifically β-cells. In these...
Aims Although peroxisome proliferator‐activated receptors (PPARs)α/γ dual agonists can be beneficial for treatment of dyslipidemia in patients with type 2 diabetes, their use is limited owing to various side effects, including body weight gain, edema, and heart failure. We aimed demonstrate that amodiaquine, an antimalarial agent, has potential as a PPARα/γ agonist low risk adverse effects. Methods screened Prestwick library (Prestwick Chemical; Illkirch, France) identify novel selected...
The assessment of skin cancers in the clinical setting is often difficult, with important features such as depth and width remaining unknown until biopsy pathology reports are received. When we remove cancers, those especially involving face, aesthetics invasion to surrounding structures bone cartilage for deciding optimal surgical procedure future reconstructive options. aim study was compare accuracy ultrasound system vivo correlate results histopathological tumor thickness measured cancer...
Tumors of the oral cavity are highly vascularized malignancies. Disruption neovascular networks was shown to limit access nutrients and oxygen tumor cells inhibit progression. Here, we evaluated effect activation an artificial death switch (iCaspase-9) expressed in endothelial on progression tumors. We used biodegradable scaffolds co-implant human dermal microvascular stably expressing iCaspase-9 (HDMEC-iCasp9) with cancer luciferase (OSCC3-luc or UM-SCC-17B-luc) immunodeficient mice....
Chronic exposure to prenatal stress can impair neurogenesis and lead irreversible cognitive neuropsychiatric abnormalities in offspring. The retina is part of the nervous system; however, impacts on retinal visual function remain unclear. This study examined how elevated glucocorticoid levels differentially affect development offspring pregnant mice exposed chronic unpredictable mild (CUMS). Offspring were classified into control, stress-resilient, stress-susceptible groups based behavioral...
The purpose of this case report was to present the treatment continuous renal replacement therapy (CRRT) in dogs with end-stage CKD uncontrolled uremia. Hemodialysis were carried out 6 patients who failed improve clinical status conventional management for CKD. Four urea reduction ratio (URR) range 57-72% and 1 dog URR 37.3% showed good outcome decreasing tendency pre-dialysis Therefore, we suggest that CRRT could be recommended use azotemia or uremia should monitor carefully throughout CRRT.