A5081884564- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Cultural Heritage Materials Analysis
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Building materials and conservation
- Plasmonic and Surface Plasmon Research
- Conservation Techniques and Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Molecular Sensors and Ion Detection
- Microfluidic and Capillary Electrophoresis Applications
- Alzheimer's disease research and treatments
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Bone Tissue Engineering Materials
- Metabolism and Genetic Disorders
- DNA and Nucleic Acid Chemistry
- Bacteriophages and microbial interactions
- Advanced Proteomics Techniques and Applications
- Urban Planning and Landscape Design
- Legal and Labor Studies
- Supramolecular Chemistry and Complexes
- Molecular Junctions and Nanostructures
- Gold and Silver Nanoparticles Synthesis and Applications
- Electron and X-Ray Spectroscopy Techniques
Istituto Nazionale Biostrutture e Biosistemi
2012-2025
University of Catania
2016-2025
University of Turin
2022
Consorzio Interuniversitario Reattività Chimica e Catalisi
2017
Consortium GARR
2015
Institute of Biostructure and Bioimaging
2005-2012
Consorzio Roma Ricerche
2011-2012
Institute for Microelectronics and Microsystems
2009
National Health Service
2007
Sapienza University of Rome
1991
This Perspective discusses recent advances in the field of surface plasmon resonance imaging (SPRi) for label-free, multiplex, and sensitive study biomolecular systems. Large efforts have been made during past decade with aim developing even more specific SPRi-based platforms. Metal nanostructures used to enhance SPRi sensitivity build a SPR-active surface, while special effects such as long-range SPR investigated develop effective Here, we review some significant work performed...
Abstract Organic electronic transistors are rapidly emerging as ultrahigh sensitive label‐free biosensors suited for point‐of‐care or in‐field deployed applications. Most organic reported to date based on immunorecognition between the relevant biomarkers and immobilized antibodies, whose use is hindered by large dimensions, poor control of sequence, relative instability. Here, an electrolyte‐gated field effect transistor (EGOFET) biosensor where recognition units surface peptide aptamers...
Ultrasensitive detection protocols not requiring polymerase chain reaction (PCR)-mediated target DNA amplification are expected to significantly improve our possibilities in several research and diagnostic applications for which minute cell quantities available. For this reason we have tested a nanoparticle-enhanced surface plasmon resonance imaging (SPRI) sensing strategy detect point mutations nonamplified genomic DNA. We used DNAs, subject costly, time-consuming, prone contamination...
Abstract Accumulation of neurotoxic amyloid‐β peptide (Aβ) and alteration metal homeostasis (metallostasis) in the brain are two main factors that have been very often associated with neurodegenerative diseases, such as Alzheimer’s disease (AD). Aβ is constantly produced from amyloidprecursor‐protein APP precursor immediately catabolized under normal conditions, whereas dysmetabolism and/or ions seems to lead a pathological deposition. Although insulin‐degrading enzyme (IDE) metalloprotease...
Gold nanoparticles (AuNPs) exhibit unique properties that can be modulated through a tailored surface functionalization, enabling their targeted use in biochemical sensing and medical diagnostics. In particular, streptavidin-modified AuNPs are increasingly used for biosensing purposes. We report here study of surface-functionalized with streptavidin-biotinylated oligonucleotide, focussing on the role played by oligonucleotide probes stabilization/destabilization functionalized nanoparticle...
Standard protocols for the analysis of circulating tumor DNA (ctDNA) include isolation from patient's plasma and its amplification in buffered solutions. The application such is hampered by several factors, including complexity time-constrained preanalytical procedures, risks sample contamination, extended time, assay costs. A recently introduced nanoparticle-enhanced surface plasmon resonance imaging-based has been shown to simplify procedures direct detection plasma, greatly simplifying...
Paramagnetic centers at the surface of ionic oxides in form trapped electrons can be generated by exposure material to alkali metal or hydrogen atoms molecular under UV irradiation. For many years, it has been assumed that resulting paramagnetic consist oxygen vacancies filled one electron. High-resolution electron spin resonance spectra and ab initio quantum chemical calculations show (H(+))(e(-)) pairs formed morphological irregularities surface. At least three different kinds centers,...