A5024817433- Reproductive Biology and Fertility
- Ovarian function and disorders
- Lung Cancer Treatments and Mutations
- Gene expression and cancer classification
- Sperm and Testicular Function
- Lung Cancer Research Studies
- Cardiac and Coronary Surgery Techniques
- Reproductive Health and Technologies
- Cancer therapeutics and mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiac Valve Diseases and Treatments
- Metabolomics and Mass Spectrometry Studies
- Pluripotent Stem Cells Research
- Genetic and phenotypic traits in livestock
- Advanced Breast Cancer Therapies
- Bioinformatics and Genomic Networks
- Ovarian cancer diagnosis and treatment
- Prenatal Screening and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Family Dynamics and Relationships
- Coronary Interventions and Diagnostics
Institute of Oncology Ljubljana
2013-2022
University of Ljubljana
2022
Ljubljana University Medical Centre
2012-2016
In in vitro fertilization (IVF) cycles controlled ovarian hyperstimulation (COH) is established by gonadotropins combination with gonadotropin-releasing hormone (GnRH) agonists or antagonists, to prevent premature luteinizing (LH) surge. The aim of our study was improve the understanding gene expression profile cumulus cells (CC) terms stimulation protocol and oocyte maturity. We applied Affymetrix profiling CC oocytes at different maturation stages using either GnRH antagonists. Two...
Balloon aortic valvuloplasty (BAV) is a percutaneous treatment option for severe, symptomatic stenosis. Due to early restenosis and failure improve long term survival, BAV considered palliative measure in patients who are not suitable open heart surgery due increased perioperative risk. can be used also as bridge surgical or transcatheter valve implantation (TAVI) haemodinamically unstable require urgent major non-cardiac surgery.
Since the introduction of in vitro fertilization (IVF) clinical practice infertility treatment, indicators for high quality embryos were investigated. Cumulus cells (CC) have a specific gene expression profile according to developmental potential oocyte they are surrounding, and therefore, could be used as biomarker. The aim our study was combine more than one biomarker observe improvement prediction value embryo development. In this study, 58 CC samples from 17 IVF patients analyzed. This...
Since 1983, Slovenia has been offering well-established, successful, and fully reimbursed IVF programme to infertile couples. On the grounds of data gathered at Slovenian units we aimed determine whether accessible treatment system can provide notable success considering cumulative delivery rate (cDR). Longitudinal analysis getting cDR was performed in 810 cycles 395 couples who for first time attended year 2006 were followed until 2012. We calculated actual optimistic cDR. In women aged<38...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective treatments for EGFR mutation-positive (EGFRm) non-small cell lung cancer (NSCLC). However, routine clinical practice is different between countries/institutions.The REFLECT study (NCT04031898) a retrospective medical chart review that explored real-life treatment and outcomes of EGFRm NSCLC patients receiving first-line (1L) first-/second-generation (1G/2G) TKIs in 8 countries. This included adult with...
Analysis of follicular fluid (FF), granulosa (GC) and cumulus cells (CC) gene expression can unravel the physiology oocyte maturation. In our previous study, a meta-analysis microarray results showed that prokineticin 2 (PROK2) pregnancy up-regulated non-ubiquitis CaMkinase (PNCK) genes are differentially expressed between GC CC. Follicular represents an important medium for It contains mediators folliculogenesis their identification would help us better understand process The aim this...
Analysis of biochemical characteristics follicular fluid (FF) can serve as a non-invasive method for the prediction oocyte and embryo quality. The aim present study was to compare concentrations anti-mullerian hormone, bone morphogenetic protein 15 transforming growth factor s1 in FF follicles giving rise high quality embryos between natural stimulated IVF cycles. Concentration BMP-15 significantly higher concentration TGF-s1 was lower in Concentrations markers were different This could be...