A5009571496- Pituitary Gland Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Neurofibromatosis and Schwannoma Cases
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
Universidade de São Paulo
2010-2023
Universidade de Ribeirão Preto
2023
Universidade Federal de Uberlândia
2015
Pituitary stem cells play a role in the oncogenesis of human adamantinomatous craniopharyngiomas (aCPs). We hypothesized that crosstalk between Wnt/β-catenin and Sonic Hedgehog (SHH) pathways, both which are important normal pituitary development, would contribute to pathogenesis aCPs.To explore mRNA protein expression components SHH signaling pathway aCPs their relationship with identification CTNNB1/β-catenin mutations patients outcomes.In 18 aCP samples, CTNNB1 was sequenced, levels...
Abstract CTNNB1 mutations and abnormal β-catenin distribution are associated with the pathogenesis of adamantinomatous craniopharyngioma (aCP). We evaluated expression canonical Wnt pathway components in aCPs its association tumor progression. Tumor samples from 14 aCP patients normal anterior pituitary eight individuals without disease were studied. Gene activator (WNT4), inhibitors (SFRP1, DKK3, AXIN1, APC), transcriptional (TCF7), target genes (MYC, WISP2, and, CDH1), modulator (TP53) was...