A5053234165- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Advanced Thermodynamic Systems and Engines
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Celiac Disease Research and Management
- Virus-based gene therapy research
- Viral Infections and Vectors
- Probiotics and Fermented Foods
- SARS-CoV-2 and COVID-19 Research
Nizhniy Novgorod Research Institute of Epidemiology and Microbiology named after Academician I.N. Blokhina
2012-2024
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2021-2024
N. I. Lobachevsky State University of Nizhny Novgorod
2012
Abstract Accumulation of mutations in the amino acid sequence immunologically significant regions outer capsid proteins locally circulating rotaviruses may reduce effectiveness vaccine-generated protection. The aim work was to comparatively analyze Russian and strains Indian pentavalent vaccine approved for use Federation 2020. Methods. There were used 38 rotavirus-positive samples derived from children with acute intestinal infection identified 2022-2023. cDNA fragments VP7 gene 877 bp long...
Animal rotaviruses (RV) play a significant role in the formation of new variants epidemiologically human group A rotavirus (RVA) strains.A reassortant variant genotype G3P[8] which has been shown to originate from RV horses and cattle currently dominates on territory Russian Federation. In addition, genotypes G3P[3], G3P[9], G6P[9], similar cats dogs, have sporadically identified world for long time. Given relevance this topic, detailed study AU-1-like genetic RVAs, whose representatives are...
Type of enterovirus was detected in 2753 cases when examining 4122 patients with various clinical forms infection (EVI) during the 2017-2018 period. We identified viruses 42 types belonging to Enterovirus A-B-С species. The ratio EV-A: EV-B: EV-C species 51.29 percent: 47.06 1.65 percent. In 413 environment samples 29 non-polio enteroviruses were identified, three which, CA14, EVA76 and ECHO25, not period EVI. Coxsackie A6 virus, which caused a drastic increase morbidity exanthema dominant...
The pentavalent rotavirus vaccine has been registered in Russia, however, the vaccination coverage remains low, and an annual increase incidence of infection is unavoidable. In this regard, molecular monitoring rotaviruses order to search for new variants possessing epidemic potential urgent task.PCR genotyping VP4 VP7 genes sequencing were used characterize circulating Nizhny Novgorod 2012-2020. phylogenetic analysis strains was carried out using BEAST software package.The spectrum included...
Group A rotaviruses (RVA) are the main cause of viral gastroenteritis in children worldwide. In this study we provide molecular characteristics reassortant DS-1-like G1P[8] RVA strains detected Russia for first time. Previously, such were Japan and Thailand. The RVAs with short electropherotype RNA-PAGE isolated from hospitalised an acute during 2013-2014 period. accounted 2.6% all continuously throughout season. phylogenetic analysis was made on basis established nucleotide sequences genes...
Aim. Study the manifestations of epidemic process rotavirus infection in Nizhny Novgorod pre-vaccination period to evaluate possible effect on morbidity for vaccine application introduction. Materials and methods. Rotavirus data were analyzed 12-year (2005 - 2016), as well its age season distribution. genotyping was carried out using multiplex PCR partial sequencing VP4 VP7 genes. Results. RVI shown be at a moderate level when specific prophylaxis not applied, multi-year dynamics reflects...
In recent years the presence of reassortant rotavirus strains is increasingly mentioned in world due to application full-genome based classification system. Information on circulation such territory Russia limited. The aim this work was development approach for determination genotypes segments encoding VP6 (I) and NSP4 (E) reveal strains.Rotavirus-positive samples were studied by means nucleotide sequencing multiplex PCR. Phylogenetic analysis conducted using Bayesian approach.Three alleles...
On the territory of Russian Federation in overall structure acute intestinal infections proportion viral diarrhea among children varies from 24 to 78% cases depending on season. The etiological confirmation is performed mainly patients infectious hospitals. prevalence non-infectious hospitals, including associated with medical care, remains unclear. Currently estimation component consists determination rotavirus infection excluding other pathogens. As part etiology hospital epidemiological...
Rotavirus infection is the major cause of severe dehydrating diarrhea requiring hospitalization in young children worldwide. Due to their segmented genome, rotaviruses are capable gene reassortment, which makes emergence and spread genetically novel strains possible. The purpose this study was search for unusual circulating Nizhny Novgorod 2021‒2023 molecular genetic characterization based on all genome segments.
<title>Abstract</title> Norovirus is one of the leading causes acute gastroenteritis worldwide and characterized by significant genetic diversity. In this study, based on phylogenetic analysis genome sequences noroviruses circulating in Nizhny Novgorod 2014–2023, as well those retrieved from GenBank database, return to active circulation C variant GII.17[P17] genotype, displaced 2015–2016 D variant, shown. A new subvariant C2, different C1 middle last decade, was identified. Amino acid...
Introduction. Rotaviruses of group A (RVA) with genotype G9P[8] are a common cause acute gastroenteritis in children Russia. In Nizhny Novgorod, the part among all RVA strains reached 63.1% during 20162017 epidemic season. Two live rotavirus vaccines, RotaTeq and Rotarix have been successfully introduced into national immunization programs worldwide. addition, Indian vaccine Rotavac, based on strain genotype, is used regional level. The parent for mentioned vaccines were isolated more than...
Abstract Reassortant DS-1-like Rotavirus A strains have been shown to widely circulate in many countries around the world. In Russia, real contribution of such remains unclear due preferred use traditional binary classification only. this work, we obtained data on partial sequencing all 11 genome segments and presented full-genotype constellations rare reassortant rotaviruses circulating Nizhny Novgorod 2016-2019. G3P[8] G8P[8] were found, it emphasized global trend. Most likely, they...