A5087142035- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Diet, Metabolism, and Disease
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Multiple Myeloma Research and Treatments
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Protease and Inhibitor Mechanisms
- Abdominal vascular conditions and treatments
- Biological Research and Disease Studies
UNSW Sydney
2014-2023
Ingham Institute
2014-2023
South Western Sydney Local Health District
2014-2020
St Vincent's Clinic
2016
Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is HGF–c-MET pathway. Effects HGF inhibition (using a neutralising antibody AMG102) alone or in combination gemcitabine were assessed (i) vivo using an orthotopic model PC, and (ii) vitro cultured (AsPC-1) human PSCs. We have shown PSCs (hPSCs) secrete but do not express receptor c-MET, present...
Activated cancer-associated human pancreatic stellate cells (CAhPSCs, which produce the collagenous stroma of cancer [PC]) are known to play a major role in PC progression. Apart from inducing cell proliferation and migration, CAhPSCs have also been implicated neoangiogenesis PC. However, mechanisms mediating observed angiogenic effects unknown. A candidate pathway that may be involved this process is hepatocyte growth factor (HGF)/c-MET its helper molecule, urokinase-type plasminogen...
Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes. Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with to facilitate disease progression. A candidate growth factor pathway that may mediate this interaction is hepatocyte (HGF)/c-MET pathway. HGF produced by PSCs its receptor c-MET expressed cells. We studied effects progression inhibiting HGF/c-MET presence absence a representative chemotherapeutic agent, gemcitabine. Using...
Background Chronic pancreatitis, a known complication of alcohol abuse, is characterized histopathologically by prominent fibrosis. Pancreatic stellate cells ( PSC s) are responsible for producing this fibrous tissue in chronic pancreatitis and activated alcohol. Progression alcoholic (as assessed calcification fibrosis) thought to be facilitated concurrent smoking, but the mechanisms unknown. This study aimed (a) determine whether human PSCs (hPSCs) rat s express nicotinic acetylcholine...
Abstract Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the interaction between cells stromal stellate (PSCs). This study assessed effect of HGF/c-MET inhibition plus gemcitabine (G) on progression advanced PC. Methods Orthotopic was produced by implantation luciferase-tagged human + PSCs into mouse pancreas. Tumours were allowed to develop without treatment for 4 weeks....
Pancreatic cancer (PC) is a deadly with high mortality rate. The unique characteristics of PC, including desmoplasia and immunosuppression, have made it difficult to develop effective treatment strategies. stellate cells (PSCs) play crucial role in the progression disease by interacting cells. One key mediators PSC - cell interactions hepatocyte growth factor (HGF)/c-MET pathway. Using an immunocompetent vivo model PC as well vitro experiments, this study has shown that combined approach...
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related deaths with a dismal 5-year survival rate only 8%. PDAC characterised by extensive desmoplasia constituting about 50–80% tumour volume. Activated pancreatic stellate cells (PSC) are major cellular source for stromal collagen; these drive fibrosis and progression PDAC. PSC known to be activated paracrine signals from several sources including injured epithelium, cells, extracellular matrix, immune nerve...
Background: Multiple myeloma (MM) remains incurable despite high-dose chemotherapy, autologous stem cell transplants and novel agents. Even with the improved survival of MM patients treated agents, including bortezomib (Bz), therapeutic options in relapsed/refractory remain limited. The majority eventually develop resistance to Bz, although mechanisms are poorly understood. Methods: Lysosomal associated membrane protein 2A (LAMP2A) mRNA expression levels were assessed ex vivo patient samples...
Background: Inhibition of hepatocyte growth factor (HGF)/c-MET pathway, a major mediator pancreatic stellate cell (PSC)−PC interactions, retards local and distant cancer progression. This study examines the use this treatment in preventing PC progression after resection. We further investigate postulated existence circulating PSCs (cPSCs) as metastatic PC. Methods: Two orthotopic mouse models, produced by implantation mixture luciferase-tagged human cells (AsPC-1), were used. Model 1 mice...
There is a lack of satisfactory animal models to study adjuvant and/or neoadjuvant therapy in patients being considered for surgery pancreatic cancer (PC). To address this deficiency, we describe mouse model involving orthotopic implantation PC followed by distal pancreatectomy and splenectomy. The has been demonstrated be safe suitably flexible the various therapeutic approaches neo settings. In model, tumor first generated implanting mixture human cells (luciferase-tagged AsPC-1)...
There is a lack of satisfactory animal models to study adjuvant and/or neoadjuvant therapy in patients being considered for surgery pancreatic cancer (PC). To address this deficiency, we describe mouse model involving orthotopic implantation PC followed by distal pancreatectomy and splenectomy. The has been demonstrated be safe suitably flexible the various therapeutic approaches neo settings. In model, tumor first generated implanting mixture human cells (luciferase-tagged AsPC-1)...