D. Hakem

ORCID: 0000-0003-3243-5730
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About
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Research Areas
  • Systemic Lupus Erythematosus Research
  • Ocular Diseases and Behçet’s Syndrome
  • Pulmonary Hypertension Research and Treatments
  • Cerebral Venous Sinus Thrombosis
  • Lysosomal Storage Disorders Research
  • Venous Thromboembolism Diagnosis and Management
  • Retinal and Optic Conditions
  • Diabetes and associated disorders
  • Acute Ischemic Stroke Management
  • Tuberculosis Research and Epidemiology
  • Celiac Disease Research and Management
  • Vasculitis and related conditions
  • Sarcoidosis and Beryllium Toxicity Research
  • Dermatological and Skeletal Disorders
  • Infectious Diseases and Tuberculosis
  • Autoimmune and Inflammatory Disorders Research
  • Diagnosis and treatment of tuberculosis
  • Otitis Media and Relapsing Polychondritis
  • Chronic Lymphocytic Leukemia Research
  • Renal Diseases and Glomerulopathies
  • Adolescent and Pediatric Healthcare
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Healthcare Systems and Practices
  • Protein Tyrosine Phosphatases
  • Cardiac, Anesthesia and Surgical Outcomes

Université de Mostaganem
2021-2024

Centre Hospitalo-Universitaire Bab El Oued
2011-2022

Hôpital Mustapha Pacha
2015

Médecins du Monde
2011

Atatürk University
2011

Aim and Methods . In this study, we evaluated NOS arginase activities their regulation during Behçet disease, a systemic chronic inflammatory disorder with uncertain etiology. The peripheral blood mononuclear cells of 36 patients 15 control samples (PBMC) were cultured in either RPMI 1640, MEM, or DMEM complemented 10% FBS antibiotics. Cultures performed without the plasma. Subsequent treatment contained anticytokines (IL-6, TGF- β ), mitogenic effector (PHA), modulators (L-NMMA, BH4)....

10.1155/2015/241738 article EN cc-by International Journal of Inflammation 2015-01-01

Background: Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It associated the presence various inflammatory molecules. Vitamin D plays an important role in regulation metabolism homeostasis. Objective: The main goal this work to investigate vitamin levels among Algerian MetS patients its possible outcomes on key molecules immune response, well, immunomodulatory effects active...

10.2174/1871530320666200402121917 article EN Endocrine Metabolic & Immune Disorders - Drug Targets 2020-04-02

Case 1: A 25 year-old woman, presented with asthenia; weight loss; severe hypertension and acute unilateral anterior uveitis.She had also proteinuria; hematuria; aciduria; kidney failure grade I hypertensive retinopathy.Kidney biopsy showed a non caseating granuloma in the interstitial tissue, tubulointerstitial nephritis (TIN) granulomatous lesions medullary parenchyma.All explorations were negative but QuantiFERON was 10 times normal without koch's bacillus.No other sites of granulomas.The...

10.4172/2161-0959.1000252 article EN Journal of Nephrology & Therapeutics 2016-01-01

10.1016/j.rmra.2023.11.527 article FR Revue des Maladies Respiratoires Actualités 2024-01-01

10.1016/j.revmed.2014.03.281 article FR La Revue de Médecine Interne 2014-05-21

<h3>Background</h3> PTPN22 is a protein phosphatase regulating negatively T-cell activation and participates in BCR signaling pathways. C1858T single nucleotide polymorphism (SNP) encoding the R620W allele variant has been associated with autoimmunity as it leads to increased levels of auto reactive immature B cells, reduced fewer cells deletion. Genetic data strongly support link between SNP susceptibility number autoimmune diseases including SLE, RA, type 1 diabetes, immune thyroiditis....

10.1136/annrheumdis-2015-eular.6249 article EN Annals of the Rheumatic Diseases 2015-06-01
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