A5039578045- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Body Contouring and Surgery
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- interferon and immune responses
- Impact of Light on Environment and Health
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Diabetes Treatment and Management
- Cell death mechanisms and regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circadian rhythm and melatonin
- Diet, Metabolism, and Disease
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
Third Xiangya Hospital
2021-2025
Central South University
2021-2025
Background and objectives: Chinese type 2 diabetes mellitus (T2DM) patients are characterized by a low body mass index (BMI), significant insulin resistance (IR). The triglyceride glucose (TyG) has not been studied as means of assessing IR in T2DM with BMI < 35 kg/m2. Materials Methods: An open-label cross-sectional study recruited 102 hyper-insulinemic euglycemic clamp, homeostatic model assessment (HOMA-IR), TyG were used to determine the level IR. Based on Pearson’s correlations, disposal...
The inhibitor of apoptosis protein survivin has a critical regulatory role in carcinogenesis and treatment tolerance colorectal cancer (CRC). However, the targeted drugs for are extremely limited. In present research, we discovered that Tanshinone IIA (Tan IIA) played dual inhibiting tumorigenesis reversing 5-Fu via modulating expression phosphorylation CRC cells. Mechanistically, Tan suppressed Akt/WEE1/CDK1 signaling pathway, which led to downregulation Thr34 destruction interaction...
This study aimed to assess the causal relationship between visceral obesity and type 2 diabetes subsequently screen adipose tissue (VAT)-specific targets for diabetes.We examined VAT using bidirectional Mendelian randomisation (MR) followed by multivariable MR. We conducted a transcriptome-wide association (TWAS) leveraging prediction models large-scale genome-wide (74,124 cases 824,006 controls) identify candidate genes in used summary-data-based MR (SMR) co-localisation analysis map genes....
Background: Insulin resistance (IR) is closely associated with the pathogenesis of type 2 diabetes mellitus (T2DM). However, remission insulin sensitivity after bariatric surgery in patients T2DM and a body mass index (BMI) 27.5-32.5 kg/m2 has not been fully elucidated. Methods: Thirty-six BMI were prospectively consecutively recruited for laparoscopic Roux-en-Y gastric bypass (LRYGB) or sleeve gastrectomy (LSG). Hyperinsulinemic euglycemic clamp, oral glucose tolerance test (OGTT), other...
Obesity is a global public health problem that imposes heavy economic burden on society. The current main strategies for treating obesity include lifestyle interventions, pharmacological treatments, endoscopic treatments and metabolic surgery. With the development of medical technology, weight reduction by intragastric occupancy devices represented balloons capsules are gradually emerging. Intragastric used to reduce occupying volume stomach with filled different volumes gas or liquid, among...
Abstract Background Previous studies have shown that artificial light at night (ALAN) is associated with obesity in adults or school-aged children, however, without addressing the critical transition period from adolescence to young adulthood. Methods In this study, we recruited incoming students five geographically dispersed universities across China whose mean ALAN (nanowatts/cm 2 /sec) during was obtained using remotely observed nighttime data matched information on their residence. Body...