A5060071507- Liver Disease and Transplantation
- Biochemical effects in animals
- Selenium in Biological Systems
- Organ Transplantation Techniques and Outcomes
- Sperm and Testicular Function
- Trace Elements in Health
Karolinska Institutet
2017-2019
Karolinska University Hospital
2019
Selenium compounds influence cell growth and are highly interesting candidate for cancer chemotherapy. Over decades an extensive number of publications have reported efficient inhibitory effects with a suggested mechanisms f especially redox-active selenium compounds. However, the studies difficult to compare due high degree variations in half-maximal inhibitor concentration (IC50) dependent on cultivation conditions methods assess viability. Among other factors, variability culture may...
To study the effects of warm ischemia-reperfusion (I/R) injury on hepatic morphology at ultrastructural level and to analyze expression thioredoxin (TRX) glutaredoxin (GRX) systems.Eleven patients undergoing liver resection were subjected portal triad clamping (PTC). Liver biopsies collected three time points; first prior PTC (baseline), 20 min after (post-ischemia) reperfusion (post-reperfusion). Electron microscopy morphometry used quantify changes, respectively. Additionally, gene...