A5002774542- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- T-cell and Retrovirus Studies
- Biblical Studies and Interpretation
- Microbial infections and disease research
- Christian Theology and Mission
- Rabies epidemiology and control
- Hepatitis Viruses Studies and Epidemiology
- Hemophilia Treatment and Research
- Vector-borne infectious diseases
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- RNA and protein synthesis mechanisms
- HIV/AIDS Impact and Responses
- Tuberculosis Research and Epidemiology
- Animal Behavior and Welfare Studies
- Plant and Fungal Interactions Research
- Mosquito-borne diseases and control
- Streptococcal Infections and Treatments
- Vaccine Coverage and Hesitancy
- Zoonotic diseases and public health
Australian Centre for Disease Preparedness
2015-2024
CSIRO Health and Biosecurity
2017-2024
Australian Government
2024
Digital Research Alliance of Canada
2023
Project Directorate on Foot and Mouth Disease
2023
Commonwealth Scientific and Industrial Research Organisation
2013-2021
Onderstepoort Veterinary Institute
2005-2017
University of Pretoria
2006-2017
Onderstepoort Veterinary Academic Hospital
2004-2015
Scientific Services
2009
African swine fever (ASF) is widespread in Africa but rarely introduced to other continents. In June 2007, ASF was confirmed the Caucasus region of Georgia, and it has since spread neighboring countries. DNA fragments amplified from genome isolates domestic pigs Georgia 2007 were sequenced compared with virus (ASFV) establish genotype virus. Sequences obtained 4 regions, including part gene B646L that encodes p72 capsid protein, complete E183L CP204L genes, which encode p54 p30 proteins...
African swine fever virus (ASFV) is one of the most threatening infectious diseases pigs. There are not sufficient data to indicate importance sylvatic cycle in spread and maintenance disease locally potentially, globally. To assess capacity maintain ASF environment, we investigated presence soft tickreservoirs ASFV Gorongosa National Park (GNP) its surrounding villages. A total 1,658 ticks were recovered from warthog burrows pig pens at wildlife/livestock interface GNP viral DNA was...
Transmission of a plaque-purified SAT-2 foot-and-mouth disease virus (FMDV) occurred erratically from artificially infected African buffaloes in captivity to susceptible and cattle the same enclosure; some instances transmission only after contact between persistently carriers animals lasting number months. Because rate at which FMDV mutations accumulated was approximately linear (1.64 percent nucleotide substitutions per year over region 1D gene sequenced), both that became months start...
Between November 2000 and the end of 2007, five outbreaks foot mouth disease (FMD) occurred in cattle area adjacentto Kruger National Park (KNP) north-eastern corner South Africa. To help understand factors behind these a qualitative risk assessment based on World Organisation for Animal Health (OIE) framework was adopted, using available data from published sources various unpublished African sources. Risk assessed basis following factors: Territories (SAT) type infections buffalo impala...
Identifying when past exposure to an infectious disease will protect against newly emerging strains is central understanding the spread and severity of epidemics, but prediction viral cross-protection remains important unsolved problem. For foot-and-mouth virus (FMDV) research in particular, improved methods for predicting this are critical outbreaks within endemic settings where multiple serotypes subtypes commonly co-circulate, as well deciding whether appropriate vaccine(s) exist how much...
Sequencing of part the 1D gene foot-and-mouth disease virus was used to determine relationships between SAT-2 viruses isolated from outbreaks which occurred in cattle Zimbabwe and Namibia impala South Africa 1979 1989. The results demonstrated that different countries were unrelated. Surprisingly close shown all since 1983 but two major epizootics 1989 caused by clearly different. Conversely, apparently unrelated could not be distinguished.
A longitudinal study was performed in the Kruger National Park, South Africa to investigate role of impala (Aepyceros melampus) maintaining SAT serotypes foot-and-mouth disease (FMD) virus. Three sampling sites with different histories FMD outbreaks and also varying ecology were chosen. At three monthly intervals approximately 40 bled examined for clinical at each these a period 6 years, followed by 4 years less frequent sampling. During 10 study, only observed once single site, while two...
Using age-related infection rates derived from serological data in available deterministic and specially developed stochastic simulation models, it has been possible to establish that the basic reproductive for South African Territory (SAT) type foot mouth disease virus buffalo (Syncerus caffer) are high. The models predict there is a periodicity of within herds possibly population as whole. Thus, likely be more infectious at some times than others. However, because most infections...
African buffalo (Syncerus caffer) act as maintenance hosts for foot-and-mouth disease (FMD) in southern Africa. A single can become infected with all three of the endemic serotypes FMD virus (SAT-1, SAT-2, and SAT-3) pose a threat infection to other susceptible cloven-hoofed animals. The floods 2000 Africa damaged Kruger National Park (KNP) game fence extensively, there were several accounts that had escaped from park. VP1 gene, which codes major antigenic determinant virus, was used...