A5077758216- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Molecular Spectroscopy and Structure
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Amyotrophic Lateral Sclerosis Research
- Chemical Synthesis and Analysis
- Radical Photochemical Reactions
- Chemical Reaction Mechanisms
- Oxidative Organic Chemistry Reactions
- Cholinesterase and Neurodegenerative Diseases
- Inorganic Fluorides and Related Compounds
- Catalytic Cross-Coupling Reactions
- Atmospheric Ozone and Climate
- Parkinson's Disease Mechanisms and Treatments
- Chemical Reactions and Mechanisms
- Organic Chemistry Cycloaddition Reactions
BenevolentAI (United Kingdom)
2023
Imperial College London
2016-2019
Transnational Press London
2016
Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources and Pfizer's global chemistry RKB CAS Scifinder® databases, factors that determine the site-selectivity these discussed a view to rationalising trends.
An efficient two-step synthesis of symmetrical and unsymmetrical tetrahydrospirobiquinolines from o-azidobenzaldehydes is reported. A novel series was prepared by sequential double-aldol condensation with acetone, cyclopentanone, cyclohexanone to form the corresponding o,o'-diazido-dibenzylidene-acetone, -cyclopentanone, -cyclohexanone derivatives, respectively, hydrogenation-spirocyclization. The spirodiamines were further derivatized electrophilic aromatic bromination, Suzuki coupling,...
Efficient syntheses of both enantiomers a spirodiamine diester from (l)- and (d)-aspartic acid are described. The key transformation was the conversion Boc-protected tert-butyl aspartate into derived aldehyde, two-directional Horner–Wadsworth–Emmons olefination, hydrogenation, selective acid-catalyzed Boc-deprotection spirocyclization. An alternative, approach to derivatives 1,7-diazaspiro[5.5]undecane is
A methodology for a radical Pictet–Spengler reaction promoted by visible light photoredox catalysis is described. This strategy furnishes tetrahydroisoquinoline derivatives bearing electron poor and rich substituents. The proceeds at room temperature with excellent regioselectivity the 6-endo intramolecular cyclisation. approach provides complementary method synthesis of scaffold substitution patterns inaccessible via established thermal transformations.