A5017072721- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Liver physiology and pathology
- Melanoma and MAPK Pathways
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Computational Drug Discovery Methods
- Pluripotent Stem Cells Research
- Wnt/β-catenin signaling in development and cancer
- ATP Synthase and ATPases Research
- Cancer Genomics and Diagnostics
The Gurdon Institute
2014-2022
University of Cambridge
2017-2022
Wellcome Trust
2014-2022
Wellcome/MRC Cambridge Stem Cell Institute
2020
Medical Research Council
2020
University of Siena
2015
Stem Cell Institute
2014
Abstract Background Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse organoids exhibit unlimited expansion potential, while previously reported human pancreas (hPO) cultures do not expand efficiently long-term a chemically defined, serum-free medium. We sought to generate 3D system as hPOs serve basis studies epithelium, exocrine diseases development genomically stable replacement cell therapy diabetes...
Abstract RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown. Here we describe that hepatocyte-specific loss Rnf43 / Znrf3 results steatohepatitis and increase unsaturated lipids, the absence dietary fat supplementation. Upon injury, deletion defective hepatocyte regeneration cancer, caused by an imbalance between differentiation/proliferation. Using hepatocyte-, hepatoblast- ductal...
// Nadia Casini 1 , Iris Maria Forte 2 Gianmarco Mastrogiovanni Francesca Pentimalli Adriano Angelucci 3 Claudio Festuccia Valentina Tomei Elisa Ceccherini Domenico Di Marzo Silvia Schenone 4 Maurizio Botta 5, 6 Antonio Giordano 1, 2, Paola Indovina Department of Medicine, Surgery and Neuroscience, University Siena Istituto Toscano Tumori (ITT), Siena, Italy Oncology Research Center Mercogliano (CROM), Nazionale per lo Studio e la Cura dei “Fondazione Giovanni Pascale”, IRCCS,...
The homologous E3 ubiquitin ligases RNF43/ZNRF3 negatively regulate WNT signalling activation. Recently, both genes have been found mutated in several types of cancers. Specifically, loss-of-function mutations result adenoma formation mouse small intestine. However, their role liver cancer has not explored yet. Here we describe that hepatocyte-specific deletion Rnf43/Znrf3 results altered lipid metabolism and a non-alcoholic steatohepatitis (NASH) phenotype mouse, the absence exogenous fat...
Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse organoids exhibit unlimited expansion potential, while previously reported human pancreas (hPO) cultures do not expand efficiently long-term a chemically defined, serum-free medium. We sought to generate 3D system as hPOs serve basis studies epithelium, exocrine diseases development genomically stable replacement cell therapy diabetes mellitus. Our...