Alexander Vorperian

ORCID: 0000-0003-3285-5831
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About
Contact & Profiles
Research Areas
  • Retinal Imaging and Analysis
  • Retinal and Optic Conditions
  • Retinal Diseases and Treatments
  • Glaucoma and retinal disorders
  • Advanced biosensing and bioanalysis techniques
  • Fatty Acid Research and Health
  • Cardiac Structural Anomalies and Repair
  • Eicosanoids and Hypertension Pharmacology
  • Cardiac Valve Diseases and Treatments
  • Renal and Vascular Pathologies
  • Acute Ischemic Stroke Management
  • RNA and protein synthesis mechanisms
  • Alcoholism and Thiamine Deficiency
  • Infective Endocarditis Diagnosis and Management
  • Bacteriophages and microbial interactions

University of Southern California
2021-2022

Southern California Eye Institute
2021-2022

University of California, Irvine
2019

University of California, Los Angeles
2017

Opiates, one of the oldest known drugs, are benchmark for treating pain. Regular opioid exposure also induces euphoria making these compounds addictive and often misused, as shown by current epidemic abuse overdose mortalities. In addition to effect opioids on their cognate receptors signaling cascades, induce multiple adaptations at cellular behavioral levels. As omega-3 polyunsaturated fatty acids (n-3 PUFAs) play a ubiquitous role in processes, we proposed that supplemental n-3 PUFAs,...

10.1371/journal.pone.0175090 article EN cc-by PLoS ONE 2017-04-05

Abstract The discovery of synthetic genetic polymers (XNAs) with catalytic activity demonstrates that natural are not unique in their ability to function as enzymes. However, all known examples vitro selected XNA enzymes lower than counterparts, suggesting XNAs might be limited fold into structures high activity. To explore this problem, we evaluated the potential FANAzyme 12–7, an RNA‐cleaving catalyst composed entirely 2′‐fluoroarabino nucleic acid (FANA) was evolved cleave RNA at a...

10.1002/cbic.201900596 article EN ChemBioChem 2019-11-04

Purpose To determine the relationship of various systemic and ocular characteristics with perifoveal macular vessel density in healthy African American eyes. Design A population-based cross-sectional study prospectively recruited Americans ≥40 years age. Participants underwent 3×3 mm 6×6 macula scans using spectral-domain optical coherence tomography angiography (OCTA), clinical examinations questionnaires. glaucoma, severe non-proliferative diabetic retinopathy, proliferative retinopathy...

10.1136/bjophthalmol-2021-319675 article EN British Journal of Ophthalmology 2021-11-05

Using optical coherence tomography angiography (OCTA), this study compared intrasession repeatability versus intersession reproducibility of macular vessel parameters in glaucoma and non-glaucoma subjects.6 × 6 mm2 OCTA scans (Cirrus HD-OCT 5000) were acquired from glaucomatous non-glaucomatous subjects as part an observational, longitudinal study. Vessel area density (VAD) skeleton (VSD) calculated using research-based quantification software while perfusion (PDZ) (VDZ) commercially...

10.1080/02713683.2022.2061004 article EN Current Eye Research 2022-04-06

The study objective was to evaluate the surgical outcomes of mitral valve repair in era percutaneous technology.We retrospectively reviewed 452 patients who underwent for degenerative disease between 2010 and 2021. Survival, reoperation, regurgitation recurrence were assessed using Cox regression, dichotomized those aged more than or less 60 years.Median age years (interquartile range) 52 (47-57) younger cohort 67 (63-73) older (P < .0001). Preoperative comorbidities leaflet pathology...

10.1016/j.xjon.2022.11.004 article EN cc-by-nc-nd JTCVS Open 2022-11-16
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