A5024359115- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Chronic Myeloid Leukemia Treatments
- HER2/EGFR in Cancer Research
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Pomegranate: compositions and health benefits
- Lung Cancer Treatments and Mutations
- Diabetes Treatment and Management
- Inflammatory mediators and NSAID effects
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Diabetes Management and Research
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Bone health and treatments
- Advancements in Transdermal Drug Delivery
Dasman Diabetes Institute
2024
Ministry of Health
2021-2022
Arabian Gulf University
2018-2021
Breast cancer is the most common diagnosed among females worldwide. Although breast survival has largely improved in past 30 years, it remains highly heterogeneous its response to treatment. Triple-negative (TNBC) a subtype of that lacks expression estrogen receptor (ER), progesterone (PR) and epidermal growth factor receptor-2 (Her2). While TNBC may initially be responsive chemotherapy, recurrence subsequent high mortality rates are frequently reported. Studies have shown curcumin...
Triple negative breast cancer (TNBC) is the most aggressive accounting for around 15% of identified cases. TNBC lacks human epidermal growth factor receptor 2 (HER2) amplification, hormone independent estrogen (ER) and progesterone receptors (PR) negative, not reactive to current targeted therapies. Existing treatment relies on chemotherapeutic treatment, but in spite an initial response chemotherapy, inception resistance relapse unfortunately common. Dasatinib approved second-generation...
The oral delivery of insulin is a convenient and safe physiological route administration for management diabetes mellitus. In this study, we developed poly-(styrene-co-maleic acid) (SMA) micellar system to overcome the rapid degradation in stomach, improve its absorption intestine, provide physiologically-relevant method reach portal circulation. was encapsulated into SMA micelles pH-dependent process. charge size nanoparticles were determined by dynamic light scattering. loading measured...
Triple-negative breast cancer (TNBC) is an aggressive subtype of that differs in progression, recurrence, and prognosis from other forms cancer. The heterogeneity TNBC has remained a challenge as no targeted therapy currently available. Previously, we others have demonstrated raloxifene, selective oestrogen receptor modulator, was also acting independently the receptor-α. However, raloxifene characterised by low bioavailability vivo. Thus, encapsulated into styrene-maleic acid (SMA) micelle...
Background: Pomegranate is a fruit rich in bioactive compounds such as punicalagins, gallic acid, and ellagic acid derivatives. It has been widely used since ancient times traditional medicine for wide variety of diseases. reported that compounds, polyphenols, are able to induce the expression cytoprotective enzymes, including HO-1. The contribution HO-1 activity prevention intestinal inflammation shown different models Inflammatory bowel diseases (IBD). Objective: Aim present research was...
Triple negative breast cancer (TNBC) is the most aggressive accounting for around 15% of identified cases. TNBC, by lacking estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2), unresponsive to current targeted therapies. Existing treatment relies on chemotherapeutic but, despite an initial response chemotherapy, inception resistance relapse unfortunately common. Dasatinib approved second-generation inhibitor multiple tyrosine kinases literature data strongly...
Familial hypercholesterolemia, the highly prevalent form of dyslipidemia, is a well-known risk factor for premature heart disease and stroke worldwide. Statins, which inhibit 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, are first-choice treatment dyslipidemias, have been effective in reducing myocardial infarction. However, emerging evidence indicates that statins may increase incidence new-onset type 2 diabetes by β-cell mass function. Notably, past vitro reports studying...