A5056950357- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Autoimmune Neurological Disorders and Treatments
- Infectious Encephalopathies and Encephalitis
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Anorectal Disease Treatments and Outcomes
- Inflammation biomarkers and pathways
- Immune cells in cancer
- Gastrointestinal motility and disorders
- Hidradenitis Suppurativa and Treatments
- Congenital gastrointestinal and neural anomalies
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Immune responses and vaccinations
KU Leuven
2023-2024
Amrita Institute of Medical Sciences and Research Centre
2024
Amrita Vishwa Vidyapeetham
2024
The University of Melbourne
2023-2024
Abstract Enteric glia have been recently recognized as key components of the colonic tumor microenvironment indicating their potential role in colorectal cancer pathogenesis. Although enteric modulate immune responses other intestinal diseases, interaction with cell compartment remains unclear. Through a combination single-cell and bulk RNA-sequencing, both murine models patients, here we find that acquire an immunomodulatory phenotype by bi-directional communication tumor-infiltrating...
Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate the mechanisms underlying CD, we analyzed transcriptome of cells isolated from transmural ileum patients including a trio lesions each patient: non-affected, inflamed, stenotic samples, compared them samples without CD. Our computational analysis revealed that profibrotic signals...
Enteric glial cells (EGCs) are an essential component of the enteric nervous system (ENS) and play key roles in gastrointestinal development, homeostasis, disease. Derived from neural crest cells, EGCs undergo complex differentiation processes regulated by various signalling pathways. Being among most dynamic digestive system, react to cues their surrounding microenvironment communicate with cell types systems within gut. Morphological studies recent single RNA sequencing have unveiled...
ABSTRACT Enteric glial cells (EGCs) have been implicated in colorectal cancer (CRC) pathogenesis. However, their precise mechanisms of interaction with the CRC immune cell compartment and pro-tumorigenic role remain unclear. This study aimed to investigate immunomodulatory effects EGCs on tumor-associated macrophages (TAMs) involvement progression. Using EGC depletion supplementation models, we assessed impact immunomodulation orthotopic murine CRC. Furthermore, by making use Bulk...
ABSTRACT BACKGROUND & AIMS Inflammatory bowel disease (IBD) is characterized by a dysregulated immune response against the host’s microbiome. Mucosal-associated invariant T (MAIT) cells recognize microbiota-derived riboflavin metabolites and play crucial role in mucosal homeostasis. However, their specific IBD remains enigmatic. MAIT express IL-26, novel IL-10 family cytokine with controversial IBD. We investigated functions of IL-26 using unique combination state-of-the-art 3D human...
Anti γ aminobutyric acid B(GABA B) receptor encephalitis is a rare form of autoimmune encephalitis. Our aim to study the clinical characteristics and treatment outcomes anti GABA B This retrospective case series from Neuroimmunology laboratory Amrita Institute Medical Sciences, Kochi, Kerala, India 2016 2021. A total four cases (two males, two females, age range: 13–80 years) tested positive for antibody during period. The manifestations found in our patients consisted seizures, cognitive...
SUMMARY Crohn’s disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibro-stenosis bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate complex intercellular interactions leading to CD, we analysed the transcriptome of cells isolated from transmural ileum CD patients, including a trio lesions each patient: non-affected, inflamed, stenotic samples, compared them samples non-CD patients. Our computational...