A5078658245- Coenzyme Q10 studies and effects
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Advanced battery technologies research
- Vitamin C and Antioxidants Research
- Adipose Tissue and Metabolism
- Biochemical Acid Research Studies
- Biochemical effects in animals
- Phytochemicals and Antioxidant Activities
- Muscle metabolism and nutrition
- Genomics, phytochemicals, and oxidative stress
- Metabolism and Genetic Disorders
- Vitamin K Research Studies
- Heavy Metal Exposure and Toxicity
- Advanced Battery Technologies Research
- Diet and metabolism studies
- Free Radicals and Antioxidants
- Metabolism, Diabetes, and Cancer
- Genetics and Neurodevelopmental Disorders
- Sirtuins and Resveratrol in Medicine
- Glutathione Transferases and Polymorphisms
- Hormonal Regulation and Hypertension
- Tea Polyphenols and Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Ischemia and Reperfusion
Marche Polytechnic University
2016-2025
University of Urbino
2025
San Raffaele University of Rome
2025
Zero to Three
2014
University of Pisa
2011
Lipid overload or metabolic stress has gained popularity in research that explore pathological mechanisms may drive enhanced oxidative myocardial damage. Here, H9c2 cardiomyoblasts were exposed to various doses of palmitic acid (0.06 1 mM) for either 4 24 hours study its potential physiological response cardiac cells. Briefly, assays performed included activity, cholesterol content, mitochondrial respiration, and prominent markers stress, as well determining changes potential, production...
Dyslipidemia is a prominent pathological feature responsible for oxidative stress-induced cardiac damage. Due to their high antioxidant content, dietary compounds, such as aspalathin and sulforaphane, are increasingly explored cardioprotective effects against lipid-induced toxicity. Cultured H9c2 cardiomyoblasts, an in vitro model routinely used assess the pharmacological effect of drugs, were pretreated with (1 μM) sulforaphane (10 before exposure palmitic acid (0.25 mM) induce...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder currently affecting ageing population. Although aetiology of PD has yet to be fully elucidated, environmental factors such as exposure naturally occurring neurotoxin rotenone been associated with an increased risk developing PD. Rotenone inhibits mitochondrial respiratory chain (MRC) complex I activity well induces dopaminergic neuronal death. The aim present study was investigate underlying mechanisms...
Objectives: Physical exercise significantly impacts the biochemistry of organism. Ubiquinone is a key component mitochondrial respiratory chain and ubiquinol, its reduced active form, an emerging molecule in sport nutrition. The aim this study was to evaluate effect ubiquinol supplementation on biochemical oxidative stress indexes after intense bout exercise.Methods: 21 male young athletes (26 + 5 years age) were randomized two groups according double blind cross-over study, either...
Coenzyme Q10 (CoQ10) is an endogenous lipophilic quinone, ubiquitous in biological membranes and endowed with antioxidant bioenergetic properties, both crucial to the aging process. In fact, coenzyme synthesis known decrease age different tissues including skin. Moreover, can be inhibited by 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors such as statins, that are widely used hypocholesterolemic drugs. They target a key enzymatic step along mevalonate pathway, involved...
In this randomized, double-blind, single-center trial (ANZCTR number ACTRN12619000436178) we aimed to investigate changes in endothelium-dependent vasodilation induced by ubiquinol, the reduced form of coenzyme Q10 (CoQ10), healthy subjects with moderate dyslipidemia. Fifty-one low-density lipoprotein (LDL) cholesterol levels 130–200 mg/dL, not taking statins or other lipid lowering treatments, (2.5%–6.0%) endothelial dysfunction as measured flow-mediated dilation (FMD) brachial artery, and...
The target of the reduced fecundity with aging is oocyte. follicular fluid and its components are strongly linked environment maturing aim present study was to evaluate CoQ10 bioavailability in fluids after oral supplementation possible implication oocyte maturation.Fifteen female partners infertile couples, aged 31⁻46, undergoing IVF-ET taking 200 mg/day were compared unsupplemented patients. content, oxidative status total antioxidant capacity evaluated also relation maturation...
Aspalathin is a rooibos flavonoid with established blood glucose lowering properties, however, its efficacy to moderate complications associated hepatic insulin resistance unknown. To study such effects, C3A liver cells exposed palmitate were used as model of resistance. These hepatocytes displayed impaired substrate metabolism, including reduced transport and free fatty acid uptake. defects included signaling, evident through phosphatidylinositol-4,5-bisphosphate 3-kinase/ protein kinase B...
The levels of bioactive compounds in broccoli and their bioavailability following intake can be affected by the cooking procedures used for vegetable preparation. In present pilot study, we compared human plasma antioxidant (β-carotene, lutein isothiocyanate) phylloquinone (vitamin K) on seven volunteers before after administration boiled steamed broccoli. Moreover, isothiocyanate (ITCs) were also evaluated a single dose BroccoMax®, dietary supplement containing GLSs with active myrosinase....
Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal muscle impaired mitochondrial function. Supplementation CoQ10 focusing on levels function has not investigated patients treated statins. To investigate whether concomitant administration statins increases the improves function, if changes correlate intensity myalgia. 37 men women simvastatin therapy without myalgia were randomized receive...