A5030436508- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Phytochemicals and Antioxidant Activities
- Parkinson's Disease Mechanisms and Treatments
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- RNA Research and Splicing
- Bioactive Compounds and Antitumor Agents
- Ion Channels and Receptors
Fraunhofer Institute for Translational Medicine and Pharmacology
2021-2022
Goethe University Frankfurt
2020
G-protein–coupled receptor 40 (GPR40) is a promising target to support glucose-induced insulin release in patients with type 2 diabetes. We studied the role of GPR40 regulation blood-nerve barrier integrity and its involvement diabetes-induced neuropathies. Because modulates release, we used streptozotocin model for 1 diabetes, which functions can be investigated independently effects on release. Diabetic wild-type mice exhibited increased vascular endothelial permeability showed epineural...
Oxaliplatin is a third-generation platinum-based anticancer drug that widely used as first-line treatment for colorectal carcinoma. Patients treated with oxaliplatin develop an acute peripheral pain several hours after treatment, mostly characterized by cold allodynia well long-term chronic neuropathy. These two phenomena seem to be causally connected. However, the underlying mechanisms trigger are still poorly understood. Here we show activity of transient receptor potential melastatin 8...
3627 Background: Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality worldwide, and its incidence is increasing in younger populations. Detection early-stage CRC precursor lesions, such advanced adenomas (AA), crucial for successful treatment reduces CRC-related mortality. Although non-invasive methods early detection are available increase screening compliance, their performance with respect to cancers limited. Here, we describe a novel stool-based approach...
G-protein coupled receptor 40 (GPR40) is a promising target to support glucose-induced insulin release in patients with diabetes type 2. Here, we studied the role of GPR40 regulation blood-nerve-barrier integrity and its involvement diabetes-induced neuropathies. Since modulates release, used streptozotocin-model for 1 diabetes, since here functions can be investigated independently effects on release. Diabetic wildtype mice exhibited increased vascular endothelial permeability showed...
G-protein coupled receptor 40 (GPR40) is a promising target to support glucose-induced insulin release in patients with diabetes type 2. Here, we studied the role of GPR40 regulation blood-nerve-barrier integrity and its involvement diabetes-induced neuropathies. Since modulates release, used streptozotocin-model for 1 diabetes, since here functions can be investigated independently effects on release. Diabetic wildtype mice exhibited increased vascular endothelial permeability showed...