A5044192397- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Electrolyte and hormonal disorders
- Autoimmune Bullous Skin Diseases
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lysosomal Storage Disorders Research
- Renal and Vascular Pathologies
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Complement system in diseases
- Ion Transport and Channel Regulation
- Genetic and Kidney Cyst Diseases
- Dialysis and Renal Disease Management
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Platelet Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Organ Donation and Transplantation
- Acute Kidney Injury Research
Institutul Clinic Fundeni
2016-2025
Carol Davila University of Medicine and Pharmacy
2016-2025
Weatherford College
2024
Yahoo (United Kingdom)
2019
Heidelberg University
2011
Armed Forces Hospital
1999
King Saud University
1999
Asir Central Hospital
1999
Nephrotic edema stands out as one of the most common complications nephrotic syndrome. The effective management hypervolemia is paramount in addressing this condition. Initially, "the underfill hypothesis" suggested that proteinuria and hypoalbuminemia led to fluid extravasation into interstitial space, causing intravascular hypovolemia activation neurohormonal compensatory mechanisms, which increased retention salt water. Consequently, recommended involved diuretics human-albumin infusion....
Introduction Lupus nephritis (LN) affects nearly 60% of patients with systemic lupus erythematosus and up to 30% them will progress end-stage renal disease (ESRD), despite receiving aggressive immunosuppressive therapy. The prognostic value ISN/RPS classification is controversial. Therefore, we aimed identify clinical pathological predictors outcome in LN independent this classification. Material methods Thirty-seven who underwent percutaneous kidney biopsy between 1997 2016 were included...
Background: Metabolic acidosis (MA) is frequently associated with chronic kidney disease (CKD) progression. Our aim was to compare the effect of oral sodium citrate (SC) that bicarbonate (SB) on renal function and serum correction, as well evaluate their safety profile in patients MA CKD. Methods: We conducted a prospective, single-center, randomized 1:1, parallel, controlled, unblinded clinical trial 124 CKD stages 3b 4. The primary outcome mean change estimated glomerular filtration rate...
The prevalence of atherosclerotic complications (myocardial infarction, stroke, and sudden death) is increased in end-stage renal disease (ESRD) patients, especially haemodialysis patients. Increasing evidence suggests that both general population dialysis systemic inflammation plays a dominant role the pathogenesis complications. In population, also, shows moderate to severe periodontitis can contribute inflammatory burden by increasing serum CRP levels may increase events. Moreover,...
Donor specific anti-HLA antibodies (DSA) and donor-derived cell-free DNA (dd-cfDNA) have lead to substantial progress in the non-invasive monitoring of renal allograft by being able detect or rule out subclinical rejection guide immunosuppressive changes. In this study we sought analyze clinical, de novo DSA (dnDSA) histological determinants dd-cfDNA levels. The included a cohort stable function kidney transplant (KT) recipients who underwent dnDSA testing between September 2017-December...
Enhanced Recovery After Surgery (ERAS) protocols were introduced in clinical practice to reduce complication rates and hospital stay. We performed a randomized controlled single center study evaluate perioperative benefits of an adapted ERAS protocol patients with bladder cancer who underwent radical cystectomy (RC) ileal urinary diversions (IUD).Forty five from 90 consecutive enrolled protocol. Length stay, diet issues, return bowel function, readmission complications examined.Among...
Alport syndrome (AS) is one of the most common monogenic kidney disorders. Recent studies have highlighted modifier effect variants involving podocyte and non-collagenous extracellular matrix (ECM) proteins in AS. We report a case series eight patients with genetically proven AS simultaneous ECM proteins. Our aim to describe influence such on phenotype identified 10 different type IV collagen variants. Patients were diagnosed autosomal dominant (3/8), recessive (2/8), digenic (2/8) X-linked...
The current state of non-HLA antibody testing in antibody-mediated rejection (AMR) remains not standardized and controversial. We used 2 different commercial solid-phase assays to investigate the presence antibodies a cohort kidney transplant recipients stratified according biopsy-proven AMR HLA-donor-specific status. Assay 1 evaluated 60 39 non-HLAs, which 25 were shared. From common antigens, only 36% (n = 9) have moderate correlation (r ≥ 0.6) signal intensity. observed significant...
Background: Molecular analysis in patients with nephrolithiasis (NL) and/or nephrocalcinosis (NC) enables an accurate evaluation. The existing clinical evidence regarding genetic testing adults NL is comprised of only a few cohort studies. Materials and methods: We retrospectively analyzed 49 adult diagnosed NC from single center, on whom we performed test using panel. reviewed the phenotype compared cases positive negative molecular diagnosis. Results: underwent testing. Of tested patients,...
Abstract Background Chronic kidney disease or chronic renal failure is a progressive condition defined as abnormalities of structure function, present for longer than 3 months. It estimated to affect more 10% the general population worldwide. Management CKD represents an especially large burden health systems low- and middle-income countries, it has been recognized leading public problem. Previous research articles reported age-adjusted prevalence 7.6% Romania, but hospital costs generated...
Background: Molecular analysis in patients with nephrolithiasis (NL) and/or nephrocalcinosis (NC) enables more accurate evaluation of underlying etiologies. The existing clinical evidence regarding genetic testing adults NL comprises only a few cohort studies. Materials and Methods: We retrospectively analyzed 49 adult diagnosed NC from single center, on whom we performed test using panel. reviewed the phenotype compared cases positive negative molecular diagnosis. Results: In total,...
Abstract Acute kidney injury (AKI) is a common complication after allogeneic stem cell transplantation; however, its incidence and outcome in patients transplanted for multiple myeloma (MM) unknown. We evaluated the incidence, severity, risk factors AKI within first 30 days autologous transplantation (ASCT) MM. prospectively followed 185 consecutive with MM, without chronic renal replacement therapy, who underwent ASCT; 12.5% of had MM‐associated amyloidosis. occurred 19 (10.3%) patients, 8...
Background . The aim of our study was to assess the subgingival profile 9 periodontal pathogens, by means real-time PCR, in a group predialysis chronic kidney disease patients with and without identify risk factors associated these patients. Material Methods This is single centre cross-sectional cohort performed on 70 CKD Patients received full-mouth examination following parameters were assessed: pocket depth (PPD), clinical attachment level, bleeding probing, plaque index; biofilm samples...
The Oxford classification (OC) of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as predictors outcome. We aimed to validate the OC investigate clinical significance extracapillary IgG immunostaining. examined renal outcome at December 31, 2014, 121 adult patients with biopsy proven primary IgAN between 2003 2013. endpoint was doubling serum creatinine or replacement therapy...