A5089812348- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Assistive Technology in Communication and Mobility
- Palliative Care and End-of-Life Issues
- Neurogenetic and Muscular Disorders Research
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Peripheral Nerve Disorders
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Neurofibromatosis and Schwannoma Cases
- Gaze Tracking and Assistive Technology
- Stroke Rehabilitation and Recovery
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- IgG4-Related and Inflammatory Diseases
- Nerve Injury and Rehabilitation
- Prion Diseases and Protein Misfolding
- Autoimmune and Inflammatory Disorders
- Phosphodiesterase function and regulation
- Patient Dignity and Privacy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Healthcare Decision-Making and Restraints
Mie University
2010-2024
Kinan Hospital
2024
Mie University Hospital
2006-2019
Kyoto University
2009
Medical Research Network
2007
Tohoku University
2003
Mitsubishi Group (Japan)
2003
This study aimed to: (1) develop and evaluate the Moral Distress Scale for Psychiatric nurses (MDS-P); (2) use MDS-P to examine moral distress experienced by Japanese psychiatric nurses; (3) explore correlation between burnout. A questionnaire on intensity frequency of items (the MDS-P: 15 grouped into three factors), a burnout scale (Maslach Burnout Inventory - General Survey) demographic questions were administered 391 in 2007-2008. These relatively low levels despite fact that they...
We report the first case of neuropathologically verified parkinsonism-dementia complex Kii peninsula, together with patient's brother, who had amyotrophic lateral sclerosis. The propositus woman developed parkinsonism and dementia at 63 years age died 70 without displaying clinical features brain exhibited marked atrophy frontal temporal lobes. Microscopically, there were many neurofibrillary tangles in central nervous system, most markedly mesial lobe deep nuclei, as well changes sclerosis...
We constructed a concise multidimensional care burden scale that reflects circumstances unique to Japan, with focus on intractable neurological diseases. surveyed 646 family caregivers of patients diseases or stroke using 28 preliminary items obtained from qualitative research. The results were used finalize the feeling (BIC: index caregivers), and verify its reliability validity.The survey was conducted among providing home health (PD [Parkinson's disease], SCD [spinocerebellar...
Amyotrophic lateral sclerosis (ALS) is an adult-onset intractable motor neuron disease characterized by selective degeneration of cortical neurons in the frontotemporal lobe and brainstem spinal cord. Impairment these neural networks causes progressive muscle atrophy weakness that spreads throughout body, resulting life-threatening bulbar palsy respiratory paralysis. However, no therapeutic strategy has yet been established to halt ALS progression. Although evidence for clinical practice...
Aims: The aims of this study were: (i) to clarify the general quality life (QOL) patients with intractable neurological disease; (ii) QOL caregivers these patients; and (iii) explore association in patient–caregiver pairs. Methods: A cross‐sectional survey was conducted between November 2003 May 2004 among community‐dwelling diagnosed Parkinson's disease (PD), spinocerebellar degeneration (SCD), multiple system atrophy (MSA), amyotrophic lateral sclerosis (ALS) their using a mailed,...
Introduction: Patients with amyotrophic lateral sclerosis (ALS) often require augmentative and alternative communication (AAC) to support impaired communication. We evaluated the effectiveness of an e-learning program for healthcare students on patients ALS, which was adapted from a previous face-to-face program. Methods: The included 85-min preparatory session, 165-min AAC practice 40-min review session. Fifty-five completed pre-/post-tests, practices using transparent board (Flick),...
<h3>Objective</h3> To report neuropathologic features of argyrophilic inclusions in the anterior horn cells, motor cortex Betz and neurons medullary reticular formation, spinal posterior horn, Clarke column a Japanese case familial amyotrophic lateral sclerosis with I113T substitution exon 4 copper-zinc superoxide dismutase (<i>SOD1</i>) gene. <h3>Methods Results</h3> These were stained pale pink on hematoxylin-eosin stain dark Bielschowsky stain. They positive for antibodies to...
To evaluate the effectiveness of a vein visualization display system using near-infrared light ("Vein Display") for safe and proper selection venipuncture sites indwelling needle placement in forearm.Ten second year nursing students were recruited to apply an line with without Vein Display. Another ten participants from various faculty serve as patients. The quality procedure at selected was evaluated according scale developed by authors. Time, scores patterns puncture-site compared respect...
Neuro-Sweet disease is a rare condition of central nervous involvement accompanied by cutaneous Sweet lesions. Neuropathological changes in neuro-Sweet are unknown.To describe post-mortem findings the first case disease.A 44-year-old Japanese man developed recurrent episodes cerebral and brainstem encephalitis with lesions from age 34 years. His HLA typing was B54 Cw1, symptoms MRI abnormalities markedly subsided following corticosteroid therapy. Histologically, there were multiple...
Abstract Introduction This study aims to investigate the association between presence and frequency of cortical lesions ( CL s), clinical psychological features multiple sclerosis MS ). Methods A total 19 patients with were examined using double inversion recovery DIR ) sequences 3T magnetic resonance imaging MRI classified into two groups: non‐ . In‐house software was used quantitatively determine atrophy each brain region. Activities daily living ADL estimated Kurtzke Expanded Disability...
Amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is a neurodegenerative disorder endemic to natives in southern coast area Japan. The closely resembles Guamanian ALS/PDC clinically and neuropathologically. characteristic neuropathological finding abundant neurofibrillary tangles (NFTs) without amyloid deposition. To elucidate biochemical properties hyperphosphorylated tau protein, major component NFTs, we examined brains by immunoblotting...
Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that deficiency in Parkinson's disease (PD) patients was related to the such as levodopa. investigated relationship between levels and levodopa administration period, dosage, symptoms PD patients. measured serum analyzed correlations levels, oral dosing frequency, including taste disorders. Data analyses were performed using Spearman's rank correlation coefficient. The mean level 60.5 ± 11.6 μg/dL....
平成16年度に厚生労働省特定疾患治療研究事業パーキンソン病（PD）関連疾患として受給者証が交付された75,026人のうち，電子入力され厚労省から研究用に提供されたPD 23,058人の臨床調査個人票を集計・解析した．平均年齢71.3歳，平均発症年齢62.7歳で，男女比1：1.47であった．40歳未満の若年発症PDは626人（2.7%）で，863人（3.7%）にPDの家族内発症をみとめた．初発症状は振戦が53.6%でもっとも多かった．今回の集計・解析は，対象がYahr III度以上のPD患者に限られる．このため医療費補助との関係でバイアスが入る可能性がある．医師の能力や診断基準が明瞭でないなど診断精度に問題があり，交付件数に比して利用可能な登録データ件数が少ないなど多くの制約はある．しかし本邦におけるPD患者の実態の一端を反映すると考えられた．
We aimed to review the incidence of pressure ulcers in patients with amyotrophic lateral sclerosis (ALS) on admission at a teaching hospital Mie, Japan. 592 admitted neurological ward Mie University Hospital from 1 April 2004 31 March 2006 were reviewed. A retrospective analysis was conducted based medical and nursing records about among ALS, parkinsonism (Parkinson's disease, multisystem atrophy, corticobasal degeneration progressive supranuclear palsy) other diseases. 16 (12 males four...
Background: Sialorrhea, the excessive flow of saliva from mouth, causes distress in about half patients with amyotrophic lateral sclerosis (ALS). Treatments sialorrhea ALS include systemic anticholinergic drugs, amitriptyline, botulinum toxin injection, and salivary gland radiotherapy, although each has limitations. Scopolamine transdermal patches have been used to prevent motion sickness since 1980s but also treat oropharyngeal disease, cerebral palsy, Parkinson’s disease. To date, no...
Global aphasia without hemiparesis (GAWH) is a rare stroke syndrome. Using transcranial magnetic stimulation (TMS), we evaluated 2 possible pathogenic mechanisms for GAWH: sparing of the decussated pyramidal tract, or alternatively, compensation by ipsilateral tract.Six patients were diagnosed to have GAWH Standard Language Test Aphasia Japanese. All underwent brain resonance (MR) imaging and angiography. According Trial Org 10172 in Acute Stroke Treatment (TOAST) criteria, subtype was...
Abstract Objectives Levodopa–carbidopa intestinal gel (LCIG) infusion is a useful therapy for the wearing‐off phenomenon of advanced Parkinson's disease (PD) patients. Recently, we found three PD patients that may have had zinc deficiency after LCIG infusion, possibly due to zinc‐chelating action levodopa. This study aims evaluate changes in serum levels received treatment and determine possible remedies during treatment. Materials Methods We performed prospective blood analysis before, when...