A5024091624- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Neuroscience of respiration and sleep
- Genomic variations and chromosomal abnormalities
- Neonatal Respiratory Health Research
- Growth Hormone and Insulin-like Growth Factors
- RNA regulation and disease
- Tuberous Sclerosis Complex Research
- Neurological disorders and treatments
- Neonatal Health and Biochemistry
- Diabetes Management and Research
- Congenital heart defects research
- Fetal and Pediatric Neurological Disorders
- Family and Disability Support Research
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
- Folate and B Vitamins Research
- Prenatal Substance Exposure Effects
- Pancreatic function and diabetes
- Multiple Sclerosis Research Studies
- Attention Deficit Hyperactivity Disorder
University of Eastern Finland
2012-2023
Kuopio University Hospital
2011-2023
Finland University
2015
Boston Children's Hospital
2012
Child Neurology Associates
2011
University of Turku
1988-2001
University of Helsinki
1989-2001
Public Health Institute
2001
Helsinki University Hospital
1988-2000
Children's Hospital
1997-2000
The long-term prognosis of 192 surviving children with the syndrome infantile spasms was evaluated. had been admitted to three paediatric hospitals in Helsinki at time initial diagnosis. aetiological factors were carefully studied each case. ACTH therapy employed 162, usually for about six weeks. follow-up study 3-19 (mean 10.4) years later made Children's Hospital, University Helsinki.
162 children with infantile spasms were treated ACTH at the Children9s Hospital, Helsinki, and Aurora during 1960--76. In a large proportion (37%) of treatment caused pronounced side effects, mortality was 4.9%. The most common complications infections: septic infections, pneumonias, urinary gastrointestinal infections. Other effects arterial hypertension (11), osteoporosis (2), hypokalaemic alkalosis other marked electrolyte disturbances (10). necropsy showed fresh intracerebral...
Summary: To our knowledge, ours is the first study to evaluate outcome of infantile spasms (IS) in adult patients. We analyzed 214 children born between 1960 and 1976 who had been followed for 20–35 years or until death at 3 months 30 age. Mortality was 31% (67 patients). Thirty‐six surviving patients (24%) normal (25 patients) only slightly impaired (11 intelligence as assessed by their educational abilities. Four academic occupations. Eight were married living unmarried with a partner....
In order to evaluate the occurrence of psychiatric disorder following infantile spasms, a long-term follow-up study (between three and 19 years) was made 192 children in Finland. Psychiatric disorders were found 53 children. 24 had autism (transient 14 cases), 16 whom also hyperkinetic, as an additional 29 cases from whole group. Considerable muscular hypotonia frequently combined with autism, but both tended decrease age. Autistic often psychomotor epilepsy temporal lobe abnormalities,...
Disturbances in the serotonergic system have been recognized autism. To investigate association between serotonin and dopamine transporters autism, we studied 15 children (14 males, one female; mean age 8y 8mo [SD 3y 10mo]) with autism 10 non‐autistic comparison (five five females; 9y 10mo 2y 8mo]) using single‐photon emission computed tomography (SPECT) [ 123 I] nor‐β‐CIT. The children, were during light sedation. They showed reduced transporter (SERT) binding capacity medial frontal...
This series of cases infantile spasms comprised 107 children born between 1960 and 1976 in the county Uusimaa, Finland. The incidence syndrome was 0.38 to 0.42/1000 live births has remained almost unchanged during those years, although there have been changes size different aetiological groups. importance prenatal perinatal factors, especially neonatal hypoglycaemia, as causal factors decreased, whereas numbers due infections malformations increased. Compared with investigations other...
Six boys and five girls with a mean age of 8.6 (range 3 to 13) years foetal alcohol syndrome (FAS) were studied by MRI single photon emission computed tomography (SPECT) find specific areas vulnerability. Morphological anomalies shown in six 11 patients situated both cortically subcortically: cortical atrophy (N = 2), dilated ventricle 1), corpus callosum hypoplasia cerebellar one the latter Arnold-Chiari malformation 1). Delayed myelination white matter was seen two patients. Volumetric...
The short- and long-term outcome special problems of 24 children with infantile spasms tuberous sclerosis (TS) was studied. diagnosis TS is frequently missed: white spots on the skin have to be carefully looked for. In present study, these were always found, calcifications or hypodense areas brain revealed by CT scans before one year age. addition epilepsy, manifestations included: giant cell astrocytoma, iridic heterotopia, cardiac rhabdomyoma, cysts, polycystic kidneys severe arterial...
Aim The aim of this study was to examine whether vigabatrin treatment had caused visual field defects ( VFD s) in children school age who received the drug infancy. Method In total, 35 (14 males, 21 females; median 11y, SD 3.4y, range 8–23y) were examined by static Humphrey perimetry, Goldmann kinetic or Octopus perimetry. aetiologies infantile spasms identified tuberous sclerosis n =10), other symptomatic causes =3), cryptogenic =22). Results Typical vigabatrin‐attributed s found 11 out 32...
There has been little exploration of major biologic regulators cerebral development in autism. We measured insulin-like growth factors (IGF) -1 and -2 from cerebrospinal fluid (CSF) by radio immunoassay 25 children with autism (median age 5y 5mo; range 1y 11mo-15y 10mo; 20 males, 5 females), 16 age-matched comparison without disability 7y 4mo; 1mo-15y 2mo; eight females). IGF-1 concentrations were further correlated patients head size. CSF concentration was significantly lower than the...
Previous studies have shown that recurrent severe hypoglycaemia can cause long-term cognitive impairment in children with type-1 diabetes, but the results are controversial, possibly due to heterogeneity of samples and lack comprehensive neuropsychological assessments children. The aim this study was assess effects diabetes on neurocognitive functioning a standardized, wide age-range test battery designed for assessment Eleven history hypoglycaemia, 10 without healthy control (a total 31...
SUMMARY The optic neuritis of 21 children aged between four and 14 years generally was characterized by bilateral involvement (62 per cent) papillitis (76 cent). Often acute infections or vaccinations were preceding events. Frequently there pleocytosis during the disease process, with production IgG, oligoclonal viral antibodies, which increased follow‐up. Nine these (eight female) later developed multiple sclerosis, unilateral nerves HLA Dr2 positivity. Disseminated effects on central...
The prevalence of cerebral palsy (CP) increased significantly from 1968-72 to 1978-82 in the region University Central Hospital Turku, Finland, 1.6/1,000 live births during first five-year period 2.5/1,000 second. increase was due an CP low birthweight children (p = 0.0002). distribution patterns did not change significantly. During second diagnosis made earlier all groups (except that spastic tetraplegia), though it reached statistical significance only hemi- and diplegic groups. While...
Summary: Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes the fine structure children with infantile spasms. An understanding action adrenocorticotropic hormone biochemistry and development provides, an indirect way, partial explanation biochemical events this syndrome; most these actions are well documented animal experiments. Some anticonvulsants also effective treating spasms, modern research has explained...
Aim The study aimed to assess the effects of diabetes‐related risk factors, especially severe hypoglycaemia, on academic skills children with early‐onset type 1 diabetes mellitus (T1DM). Method comprised 63 T1DM (31 females, 32 males; mean age 9y 11mo, SD 4mo) and 92 comparison without (40 52 9mo, 3mo). Children were included if had been diagnosed before 5 years they aged between 9 10 at time study. not their native language was Finnish a neurological disorder that affected cognitive...