Alan Cupino

ORCID: 0000-0003-3323-0040
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About
Contact & Profiles
Research Areas
  • Ultrasound Imaging and Elastography
  • Advanced Neuroimaging Techniques and Applications
  • Ultrasound and Hyperthermia Applications
  • Advanced MRI Techniques and Applications
  • Gastric Cancer Management and Outcomes
  • Oral health in cancer treatment
  • Glioma Diagnosis and Treatment
  • Advanced Radiotherapy Techniques
  • Fatty Acid Research and Health
  • Head and Neck Cancer Studies
  • Extracellular vesicles in disease
  • Ultrasound in Clinical Applications
  • Advanced biosensing and bioanalysis techniques
  • Nutritional Studies and Diet
  • Neurological disorders and treatments
  • RNA Interference and Gene Delivery
  • Parkinson's Disease Mechanisms and Treatments
  • MRI in cancer diagnosis
  • Antioxidant Activity and Oxidative Stress

Loma Linda University
2013-2022

University of Virginia
2008-2015

Precise focusing is essential for transcranial MRI-guided focused ultrasound (TcMRgFUS) to minimize collateral damage non-diseased tissues and achieve temperatures capable of inducing coagulative necrosis at acceptable power deposition levels. CT usually used this refocusing but requires a separate study (CT) ahead the TcMRgFUS procedure. The goal was determine whether MRI using an appropriate sequence would be viable alternative planning in TcMRgFUS. We tested three pulse sequences (3D T1...

10.1088/0031-9155/59/13/3599 article EN Physics in Medicine and Biology 2014-06-09

The purpose of this study was to investigate whether diffusion tensor imaging (DTI) the corticospinal tract (CST) is a reliable surrogate for intraoperative macrostimulation through deep brain stimulation (DBS) leads. authors hypothesized that distance on MRI from DBS lead CST as determined by DTI would correlate with motor thresholds macrostimulations same lead.The retrospectively reviewed pre- and postoperative studies recordings in 17 patients Parkinson disease (PD) treated stimulation....

10.3171/2014.6.jns131673 article EN Journal of neurosurgery 2014-07-25

Introduction The effects of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) on cerebrovascular disease remain unsettled. However, most studies have focused marine sourced n-3 PUFA rather than total PUFA, which the majority in American diet is plant derived. This study therefore intended to investigate these a cohort for vegetarian was more prevalent general public. Methods Cox proportional hazards with fatal stroke as outcome performed approximately 96,000 subject...

10.1371/journal.pone.0274109 article EN cc-by PLoS ONE 2022-09-09

CT scans have been used to refocus ultrasound for clinical transcranial MRI-guided focused (TcMRgFUS). The refocusing of the arrays is a crucial step in TcMRgFUS therapy because skulls distort sound beams due ununiformed shape and composition bone. scan based algorithms developed estimate phase shifts induced by corresponding conjugated signals are then emitted be refocused on brain targets through skull. However, elongate treatment process expose patients ionizing radiation. This study...

10.1186/2050-5736-3-s1-p21 article EN cc-by Journal of Therapeutic Ultrasound 2015-06-30

In May 2013, the American College of Surgeons Commission on Cancer (CoC) endorsed new gastric cancer quality measures recommending at least 15 lymph nodes (LN) in all resected non-metastatic non-proximal cancers.We sought to determine whether hospital CoC-accreditation predicts compliance with this guideline.We also postulated that 3-month post-gastrectomy survival may differ for patients receiving cancer-directed surgeries CoC vs non-CoC hospitals and LN count (15þ 1-14) predict survival,...

10.1093/ije/dyv096.103 article EN International Journal of Epidemiology 2015-09-23
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