A5103091392- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Travel-related health issues
- Immune Cell Function and Interaction
- Plant responses to water stress
- Influenza Virus Research Studies
- Clostridium difficile and Clostridium perfringens research
University of Washington
2006-2017
ABSTRACT Several prophylactic vaccines targeting herpes simplex virus 2 (HSV-2) have failed in the clinic to demonstrate sustained depression of viral shedding or protection from recurrences. Although these generated high titers neutralizing antibodies (NAbs), their induction robust CD8 T cells has largely been unreported, even though evidence for importance HSV-2 antigen-specific is mounting animal models and translational studies involving subjects with active HSV-2-specific immune...
ABSTRACT Herpes simplex virus (HSV) infection is restricted to epithelial cells and neurons controlled by CD8 T cells. These both traffic sites of recurrent lytic ganglia persist at the dermal-epidermal junction for up 12 weeks after lesion resolution. We previously showed that cutaneous lymphocyte-associated antigen (CLA), a functional E-selectin ligand (ESL), selectively expressed on circulating HSV-2-specific CLA/ESL mediates adhesion inflamed vascular endothelium. Later stages in T-cell...
Herpes simplex virus (HSV) infections of humans are characterized by intermittent, lytic replication in epithelia. Circulating HSV-specific CD4 T cells express lower levels preformed cutaneous lymphocyte-associated antigen (CLA), a skin-homing receptor, than do circulating CD8 but, paradoxically, move into infected skin earlier cells. Memory develop strong and selective expression CLA E-selectin ligand while responding to HSV vitro. We now show that interleukin-12, type I interferon,...
Abstract Homing of pathogen specific T-cells is an important component the host immune response. HSV-2-specific express high levels cutaneous lymphocyte-associated antigen (CLA) and related E-selectin ligand (ESL). Control CMV- or EBV-specific low CLA/ESL. CLA/ESL expression lymphocyte homing to skin are dependent on fucosyltransferases-IV –VII (FT-IV FT-VII). We used real-time PCR compare FT-VII mRNA in isolated CD8-pos for HSV-2, EBV, CMV from un-manipulated blood using tetramer (tet)...