A5004708448- Mycobacterium research and diagnosis
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Photosynthetic Processes and Mechanisms
- Bacterial biofilms and quorum sensing
- Microtubule and mitosis dynamics
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
Center for Cancer Research
2023
National Cancer Institute
2023
Institute of Genomics and Integrative Biology
2022
Academy of Scientific and Innovative Research
2022
Polo-like kinase 1 (Plk1) is considered an attractive target for anticancer therapy. Over the years, studies on noncatalytic polo-box domain (PBD) of Plk1 have raised expectation generating highly specific protein–protein interaction inhibitors. However, molecular nature canonical PBD-dependent interaction, which requires extensive water network–mediated interactions with its phospholigands, has hampered efforts to identify small molecules suitable PBD drug discovery. Here, we report...
Oligoribonucleases (Orns) are highly conserved DnaQ-fold 3'-5' exoribonucleases that have been found to carry out the last step of cyclic-di-GMP (c-di-GMP) degradation, is, pGpG GMP in several bacteria. Removal is critical for c-di-GMP homeostasis, as excess uncleaved can feedback inhibition on phosphodiesterases, thereby perturbing cellular signaling pathways regulated by c-di-GMP. Perturbation levels not only affects survival under hypoxic, reductive stress, or nutrient-limiting conditions...