Karthik Mallela

ORCID: 0000-0003-3330-955X
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About
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Research Areas
  • Tuberous Sclerosis Complex Research
  • Kruppel-like factors research
  • Cancer-related gene regulation
  • MicroRNA in disease regulation
  • Chromatin Remodeling and Cancer
  • Histiocytic Disorders and Treatments
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research

Cancer Research UK Manchester Institute
2025

University of Manchester
2025

Indian Institute of Science Bangalore
2020-2021

Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to pathogenesis oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests involvement microRNAs (miRNAs) in carcinogenesis by acting as tumor suppressors or oncogenes. TSC1, a component above pathway, regulates several cellular functions such proliferation, apoptosis, migration and invasion. Downregulation TSC1 reported well other cancers associated with an unfavourable clinical outcome patients. Here we...

10.1038/s41598-021-87388-4 article EN cc-by Scientific Reports 2021-04-08

Abstract Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to pathogenesis oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests involvement microRNAs (miRNAs) in carcinogenesis by acting as tumor suppressors or oncogenes. TSC1, a component above pathway, regulates several cellular functions such proliferation, apoptosis, migration and invasion. Downregulation TSC1 reported well other cancers associated with an unfavourable clinical outcome patients....

10.21203/rs.3.rs-130377/v1 preprint EN cc-by Research Square (Research Square) 2020-12-28
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