Purpose The aim of this study is to investigate the benefits atorvastatin on propionic acid-induced autism model via increasing sphingosine-1-phosphate and anti-inflammatory actions with imaging brain tissue investigations. Materials methods Twenty-five mg/kg/day/rat acid (PPA) was administered intraperitoneally 20 male Wistar rats, 10 rats were fed orally. Study groups designed as follows: Group 1: Control (orally control, n=10); 2 (PPA+saline, 3 (PPA+Atorvastatin, n=10). biochemical...

Although several studies demonstrate the anti-inflammatory effect of oxytocin in different pathophysiological processes, there are limited data describing impact on acute respiratory distress syndrome (ARDS). We aimed to elucidate protective ARDS with histopathological evaluation and radiological imaging addition biochemical markers.Fecal intraperitoneal injection procedure (FIP) was performed 24 32 rats included study for creating a sepsis model. Rats were randomly assigned into four...

Autism spectrum disorder (ASD) is a neurodevelopmental with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in ASD rat model induced by propionic acid (PPA) terms neurobehavioral changes and also support these histopathological changes, brain biochemical analysis magnetic resonance spectroscopy (MRS) findings.Twenty-one male rats were randomly assigned into three groups. Group 1 (control, 7 rats) did not receive treatment. Rats groups 2 3 given...

Pancreatic cancer is mostly diagnosed in advanced stages, and treatment results are not satisfactory. L3 skeletal muscle index (SMI) has emerged as a prognostic factor pancreatic patients. We aimed to assess the association between sarcopenia overall survival patients with this study.Patients who were admitted Department of Oncology March 2012 December 2019 evaluated. The computerized tomography images laboratory parameters total 115 included retrospective singlecenter study. defined an SMI...

This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) underwent Granulocyte colony stimulating factor (G-CSF) treatment. In addition, effects of G-CSF on functions were examined by magnetic resonance (MR) imaging histopathologically.This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at beginning continued for 15 days after whole-brain radiotherapy (WBRT). WBRT given...

Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known anti-inflammatory effect, this study aims to investigate effect digoxin sepsis model and bring light underlying mechanism acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis performed feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, MDA values significantly decreased FIP+digitoxin group compared...

Aims: Patients with autism have altered gut microbiata, including higher frequency of bacteroidetes and clostridiales that produce propionic acid (PPA) –a compound is established as an autism-inducing agent. We hypothesized lowering the PPA levels by regulating microbiata ursodeoxycholic (UDCA) can regress symptoms. The aim this study to examine potential ameliorating effects UDCA on a PPA-induced rat model autism. Methods: Thirty male Wistar albino rats were divided into three groups:...

BACKGROUND:Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, investigate effect papaverine on RAGE associated NF-κB pathway by determining level soluble (sRAGE) and HMGB1, support this hypothesis evaluating inflammatory biochemical, oxidative stress markers, Hounsfield unit (HU) value computed tomography (CT), histopathological results.METHODS:...

Objective: The objective of this study was to investigate the diagnostic power apparent diffusion coefficient/coefficient variance (ADCcV) as well ADC parameters formed based on magnetic resonance images (MRI) in distinction molecular breast cancer subtypes. Methods: involved 205 patients who had at stages 1-3. Estrogen receptor (EsR), progesterone (PrR), human epidermal growth factor 2 (Her2), and proliferation index (Ki-67) were histologically analyzed tumor. correlations between...

Neuroprotective effect of polyethylene Glycol (PEG-3350) on radiation-induced brain injury via membrane stabilization

The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 were divided into three groups. significant difference the levels IL-17 (p<0.05), IL-2 and TNF-α lactate nerve growth factor (p<0.05) found medroxyprogesterone-treated group by biochemical analysis. In histopathological examination, revealed improvement neural body degeneration, count, dysmorphological changes both CA1 CA3 regions. Immunohistochemical...

Abstract Background Autism is a complex neurobehavioral disorder that associated with genetic and environmental factors. Patients autism have altered gut microbiata, including higher frequency of bacteroidetes clostridiales produce propionic acid (PPA) –a compound established as an autism-inducing agent. We hypothesized lowering the PPA levels by regulating microbiata ursodeoxycholic (UDCA) can regress symptoms. Methods Thirty male Wistar albino rats were divided into three groups: controls,...

Background and Objective: Cisplatin is among the most frequently used in solid organ cancers.However, it can be dose-limiting, especially due to its side effects on kidney liver.This study aims examine protective properties of propofol from cisplatin-induced liver damage.Materials Methods: A total 24 adult female rats were included divided into 3 groups, each containing 8 rats.The 1st group was control group.The 2nd administered 2.5 mg/kg/day cisplatin 2 days a week for 4 weeks.In 3rd group,...

The most significant complication in familial mediterranean fever (FMF) patients is dysfunction and organ failure developing depending on amyloid deposition organs. golden standard for showing the biopsy; however, tissue stiffness was examined by shear wave elastography as a non-invasive method restricted number of studies conducted, it considered that can be shown indirectly. In our study, we aimed to indirectly evaluate organs with Shear Doppler ultrasonography reveal its relationship MEFV...

BackgroundPET/MRI is a hybrid imaging modality and uses for evaluating oncology patients with its bene ts of combination soft tissue contrast glucose metabolism. AimsTo evaluate the role simultaneous derived apparent diffusion coe cient (ADC) heterogeneity index 2-[ 18 F]-uoro-2-deoxy-D -glucose ( F-FDG) standardized uptake value (SUV) from PET/MRI to differentiate brain metastasis (BM) normal appearing parenchyma (NABP) nd out e ciency ADC CV SUV against conventional parameter. Study...

Amaç: Yapısal akciğer bozukluğu, enfeksiyon veya travma gibi belirli etyolojik neden bulunmayan olgular “primer spontan pnömotoraks (PSPn)” olarak isimlendirilmektedir. Çalışmamızın birincil hedefi PSPn tanısı alan hastalarda pektus ekskavatum (PE) ve sternal varyasyonlar ile arasındaki ilişkiyi değerlendirmektir. Materyal-Metod: Retrospektif tek merkezli çalışmamıza Ocak 2016-Şubat 2019 tarihleri arasında Üniversitemiz acil servisine başvuran 30 olgusu, kontrol grubu toplam 60 olgu dahil...