A5023174058- Analytical chemistry methods development
- Receptor Mechanisms and Signaling
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Computational Drug Discovery Methods
- Electronic and Structural Properties of Oxides
- Chemical Synthesis and Analysis
- MXene and MAX Phase Materials
- Monoclonal and Polyclonal Antibodies Research
- Mass Spectrometry Techniques and Applications
- Synthesis and Biological Evaluation
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- Nanopore and Nanochannel Transport Studies
- Membrane Separation Technologies
- Graphene research and applications
- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- Advanced Battery Materials and Technologies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Ferroelectric and Piezoelectric Materials
- Magnetic and transport properties of perovskites and related materials
- Cholinesterase and Neurodegenerative Diseases
Shenzhen Institute for Drug Control
2022-2024
Tsinghua University
2024
Chinese University of Hong Kong, Shenzhen
2022-2024
University of Science and Technology of China
2022-2024
Sichuan University
2010-2024
Henan University
2019-2024
Ministry of Education of the People's Republic of China
2024
Hubei University
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
A monotonical relationship between the binding energies and lattice constants of M<sub>3</sub>C<sub>2</sub>O<sub>2</sub> was identified, which indicated that MXenes with a smaller constant tends to exhibit stronger anchoring effect.
Two radical-based approaches have been developed to effect the trifluoromethylation of aryl C-H bonds in native peptides either using stoichiometric oxidant or visible light photoredox catalysis. The reported methods are able derivatize tyrosine and tryptophan sidechains under biocompatible conditions, a number examples involving fully unprotected with up 51 amino acids. development this chemistry adds growing array chemical for selectively modifying acid residues context complex peptides....
Chemodynamic therapy (CDT) has emerged as a promising approach for treating infected diabetic wounds, while reliable imaging technology simultaneous monitoring of ROS and therapeutic processes is still formidable challenge. Herein, smart covalent organic framework (COF) nanoreactors (COF NRs) are constructed by hyaluronic acid (HA) packaged glucose oxidase (GOx) covalently linked Fe-COF wound healing. Upon the breakdown HA protective layer, GOx consumes to produce gluconic hydrogen peroxide (H
Cyclic hydroxyamidines were designed and validated as isosteric replacements of the amide functionality. Compounds with these structural motifs found to be metabolically stable possess highly desirable pharmacokinetic profiles. These designs applied in identification γ-secretase modulators leading efficacious agents for reduction central nervous system Aβ(42) various animal models.
MXenes have been extensively explored as anode materials in Li, Na, and K ion batteries. However, the correlation between structural properties of their electrochemical performances has not fully understood. In present study, five typical M3C2O2 (M = V, Ti, Nb, Hf, Zr) adsorption diffusion atoms on them are studied detail by using density functional theory calculations. Based our calculated results, we found that different transition-metal-based possessed highly distinct properties, which...
Reactive oxygen species (ROS) have emerged as a promising treatment option for antibacterial and biofilm eradication. However, their therapeutic efficacy is significantly hampered by the unique microenvironments of diabetic wounds. In this study, we designed synthesized porphyrin-based Fe covalent organic frameworks (Fe-COF) through Schiff base condensation reaction. Subsequently, Fe-COF were encapsulated with hyaluronic acid (HA) electrostatic adsorption, resulting in novel formulation...
Fused oxadiazines (3) were discovered as selective and orally bioavailable γ-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure-activity relationships (SARs) did not translate from to oxadiazine series. Subsequent SAR studies at C3 C4 positions fused core helped identify GSMs such compounds 8r 8s highly efficacious in vitro vivo a number animal models with desirable physical...
A novel protein imprinted polymer, which combined the surface imprinting technology and magnetic halloysite nanotubes (MHNTs), was prepared for selective separation of a template protein.
This study reports an analytical method for the determination of nitroimidazole and quinolones in honey using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A modified QuEChERS methodology was used to extract analytes determine veterinary drugs by LC-MS/MS. The linear regression excellent at concentration levels 1–100 ng/mL solution standard curve matrix curve. recovery rates were 4.4% 59.1% 9.8% 46.2% with relative deviations (RSDs) below 5.2% ranged from 82.0% 117.8% 79% 115.9%...
Solid-state nanopore sequencing is now confronted with problems of stochastic pore clogging and too fast speed during the DNA permeation through a nanopore, although this technique revolutionary long readability high efficiency. These two are related to controlling molecular transportation sequencing. To control motion identify four bases, we propose nanoslit sensing based on planar heterostructure two-dimensional graphene hexagonal boron nitride. Molecular dynamics simulations performed...
A new method based on cloud point extraction (CPE) separation and graphite furnace atomic absorption spectrometry (GFAAS) detection was proposed for the determination of inorganic tin species. When system temperature is higher than (CPT) mixed surfactant p-octyl polyethyleneglycolphenyl ether (Triton X-100) sodium dodecyl sulfate(SDS), complex Sn(IV) with 1-(2-pyridylazo)-2-naphthol (PAN) could be extracted into surfactant-rich phase, whereas Sn(II) remained in aqueous phase. Thus, an situ...
A series of novel pyridazone and pyridone compounds as γ-secretase modulators were discovered. Starting from the initial lead, structure−activity relationship studies carried out in which an internal hydrogen bond was introduced to conformationally fix side chain, with improved vitro Aβ42 inhibition activity good Aβtotal/Aβ42 selectivity quickly Compound 35 displayed very excellent vivo efficacy both CRND8 mouse nontransgenic rat models. This compound a overall profile terms pharmacokinetics...
Wee1-like protein kinase (Wee1) is a tyrosine that regulates the G2 checkpoint and prevents entry into mitosis in response to DNA damage. Based on series of signaling pathways initiated by Wee1, Wee1 has been recognized as potential target for cancer therapy. To discover potent inhibitors with novel scaffolds, ligand-based pharmacophore model built based 101 known inhibitors. Then best model, AADRRR.340, good partial least square (PLS) statistics (R2 = 0.9212, Q2 0.7457), was selected...
We describe a facile, general, and highly efficient approach to obtain polydopamine-coated molecularly imprinted polymer based on halloysite nanotubes for bovine serum albumin. The method combined surface molecular imprinting one-step immobilized template technique. Hierarchically structured was prepared in physiological conditions adopting dopamine as functional monomer. A thin layer of polydopamine can be coated the amino-modified by self-polymerization, thickness shells controlled mass...
An approach is reported for the exclusive production of CdTe magic-size clusters (MSCs) that exhibit an optical absorption doublet peaking at 385/427 nm, with explanation synthesis procedure. The MSCs, defined as dMSC-427, were produced from reaction cadmium oleate (Cd(OA)2) and tri-n-octylphosphine telluride in octadecene 100 °C, addition acetic acid (HOAc) or acetate (M(OAc)2) during prenucleation stage (40 °C). Without such when it was performed postnucleation (100 °C), quantum dots (QDs)...
Homomeric dimerization of metabotropic glutamate receptors (mGlus) is essential for the modulation their functions and represents a promising avenue development novel therapeutic approaches to address central nervous system diseases. Yet, scarcity detailed molecular energetic data on mGlu2 impedes our in-depth comprehension activation process. Here, we employ computational simulation methods elucidate process key events associated with mGlu2, including analysis its conformational...