Betulinic acid, a very promising anti-melanoma agent, has low water solubility that causes bioavailability. To overcome this inconvenience, highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and electron microscopy (SEM) methods then in vitro tested for its antiproliferative activity by the MTT assay cell cycle analysis. Finally, vivo an...

Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis inclusion complexes between these cyclodextrins, as well their vivo evaluation on chemically induced skin cancer experimental models. In this study synergistic activity acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored...

Aiming to obtain the highest triterpene content in extraction products, nine bark samples from forest abundant flora of Apuseni Mountains, Romania were Raman spectroscopically evaluated. Three different natural extracts Betula pendula Roth birch have been obtained and characterized using Fourier transform vibrational spectra.This study shows that principal components tree extract can be rapidly recognized differentiated based on their fingerprint band shape intensity. The spectroscopy...

Determining the safety of a newly developed experimental product is crucial condition for its medical use, especially clinical trials. In this regard, four hydrogel-type formulations were manufactured, all which based on carbomer (Blank-CP940) and encapsulated with caffeine (CAF-CP940), phosphorus derivatives (phenyl phosphinic (CAF-S1-CP940) 2-carboxyethyl phenyl acids (CAF-S2-CP940)). The main aim research was to provide comprehensive outline biosafety profile above-mentioned hydrogels....

Genistein is one of the most studied phytocompound in class isoflavones, presenting a notable estrogenic activity and vitro and/or vivo benefits different types cancer such as those bladder, kidney, lung, pancreatic, skin endometrial cancer. A big inconvenience for drug development low water solubility, which can be solved by using hydrophilic cyclodextrins. The aim this study to theoretically analyze, based on interaction energy, possibility complex formation between genistein (Gen) three...

Melissa officinalis (MO) is a medicinal plant well-known for its multiple pharmacological effects, including anti-inflammatory, anticancer and beneficial effects on skin recovery. In this context, the present study was aimed to investigate in vitro vivo safety profile of an MO aqueous extract by assessing cell viability normal (HaCaT—human keratinocytes) tumor (A375—human melanoma) cells impact physiological parameters non-invasive method. addition, antioxidant activity antiangiogenic...

Background and aim: The extract of ginger, obtained from the rhizome Zingiber officinale , contains 6-gingerol, 6-shogaol, 8-gingerol, 10-gingerol. It has many therapeutic effects such as being chemopreventive against stroke heart diseases, malabsorption, bacterial infections, indigestion, nausea, which have been observed since ancient times. main aim this study is to evaluate polyurethane (PU) a proper material for hollow nanoparticles' preparation. Methods: PU nanoparticles were by...

Fine needle aspiration (FNA) is considered the gold standard in diagnostic of thyroid nodules. Using recommended BETHESDA reporting system, up to 20% results are classified as intermediate cytology. As there no consensus whether ultrasound evaluation, lobectomy or surgery best treatment option, cytology a grey zone FNA. The main aim our study was evaluate performance combined advanced techniques process diagnosis and evaluation cases after We evaluated 54 consecutive with on FNA, using...

Medicinal plants and essential oils (EOs), in particular, were intensively studied recent years as viable alternatives for antiproliferative chemical synthetic agents. In the same lines, present study focuses on investigating effects of natural preparations (emulsions) based EOs obtained from Citrus bergamia Risso (bergamot-BEO), sinensis Osbeck (orange-OEO), Syzygium aromaticum Merill et L. M. Perry (clove-CEO) different healthy (human immortalized keratinocytes-HaCaT primary human gingival...

Background: The volatile compounds present in rose extracts exhibit significant potential applications medicine and cosmetics due to their capacity enhance skin hydration barrier function, two factors that are crucial for anti-aging protection. antimicrobial, anti-inflammatory, analgesic properties of these also suggest utility oral health applications. aim the current study was obtain a new type polyurethane delivery system based on polyaddition process presence surfactant. Methods:...

Background: Scald burns pose significant morbidity, and effective topical treatments remain a clinical priority. Burn injuries challenge due to the prolonged inflammation high infection risk. Traditional focus on moisture retention prevention, but biocompatible formulations such as hydrogels oleogels offer advantages. Hydrogels hydrate, cool, promote epidermal regeneration, while form lipid barrier that enhances absorption of lipophilic bioactive compounds. There is an increasing demand for...

The isoflavonoid genistein, the aglycone of heteroside genistin, possesses preventive effect on coronary heart disease and osteoporosis, antioxidant, anthelmintic, antineoplastic anti-inflammatory properties. Much research has been undertaken regarding action genistein cancer-preventing/treating effects, especially breast prostate cancer. aim this study was to analyze compound in vivo by observing tumor size, metastasis potential melanization a mouse model murine melanoma, employing B164A5...

Given the increased prevalence of thyroid nodules in general population (~50%), real challenge resides correctly recognizing suspicious ones. This study proposes to compare four important Thyroid Imaging and Reporting Data Systems (TI-RADS) evaluate contribution elastography 4D Color Doppler assessment vascularity estimating risk malignancy. In study, 133 with histopathological examination were included. Of these, 35 (26.31%) proved be malignant. All classified using selected systems our...

Chronic kidney disease is a rising cause of morbidity and mortality in developed countries, including end-stage renal (ESRD). The prevalence thyroid comorbidities persons with chronic documented higher than normal population. study aims to investigate the morphological functional disorders patients disease, replacement therapy (hemodialysis).A cross-sectional was performed on 123 consecutive stage 5, hemodialysis during period one month (May 2019-June 2020). All were enrolled for maintenance...

Since ancient times complementary therapies have been based on the use of medicinal plants, natural preparations and essential oils in treatment various diseases. Their medical practice is recommended view their low toxicity, pharmacological properties economic impact. This paper aims to test antimicrobial effect preparation clove, orange bergamot a wide range microorganisms that cause infections humans including: Streptococcus pyogenes, Staphylococcus aureus, Shigella flexneri, Candida...

This study presents phytochemical characterization and biological evaluation of Origanum vulgare L. essential oil (OEO) formulated as polymeric micelles drug delivery systems a possible non-invasive approach for the management skin tags. GC-MS analysis Romanian OEO revealed identification quantification 43 volatile compounds (thymol carvacrol being main ones). The antioxidant activity was shown by four consecrated methods: CUPRAC, ABTS, ORAC DPPH. incorporated micellar solubilization into...

Context: Oleanolic and ursolic acids are antitumor antibacterial agents which extensively studied. Their major disadvantage is the poor water solubility limits their applications.Objectives: acid were encapsulated into polyurethane nanostructures that act as drug carriers. In order to evaluate effectiveness of particles, anti-microbial anti-proliferative activity compared un-encapsulated active compounds was tested.Materials methods: Using an interfacial polycondensation technique, combined...

Red chili peppers have been highly valued in gastronomy and traditional medicine since ancient times; it seems that is not just an ingredient for food but also a good remedy various medical conditions such as increased blood pressure high levels of serum triglycerides cholesterol, myocardial infarction, arthritis, migraines. The objective this study the characterization new carrier used encapsulated extract.Chili pepper extract was obtained physically entrapped inside polyurethane...

This study aimed to assess the serum levels of intracellular adhesion molecule (sICAM-1), and vascular cell (sVCAM-1), in first psychotic episode schizophrenia (SZ) patients, before after six months antipsychotic treatment.The included 50 patients with a hospitalization for SZ healthy control subjects that were patient-matched regarding age, gender, body mass index smoking status. The evaluation presence cardiovascular risk factors, measurements systolic diastolic blood pressure, index,...

Albendazole is a benzimidazole derivative with documented antitumor activity and low toxicity to healthy cells. The major disadvantage in terms of clinical use its aqueous solubility which limits bioavailability. was incorporated into stable homogeneous polyurethane structures the aim obtaining an improved drug delivery system model. Spectral thermal analysis used investigate encapsulation process confirmed presence albendazole inside nanoparticles. vitro anticancer properties encapsulated...

Chronic autoimmune thyroiditis (CAT) is the most common thyroid disorder in pediatric population. Ultrasound evaluation may suggest diagnosis. Additionally, shear-wave elastography (SWE) proved to be a valuable additional diagnosis tool adults with CAT by assessing stiffness (TS). This study aims assess its use also detecting children CAT. The group consisted of 50 confirmed CAT, who were compared control group, consisting no pathology and an adult subjects included, besides...

: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with or ingestion fortified foods should not be considered harmless. addresses possible correlations between physico-chemical properties and side effects when taken in high doses for a too long period.

Vitamin C sustains the health of human organism. It reduces risk chronic diseases and it can help to control arterial hypertension. In addition, prevents developing various heart diseases, normalizes level uric acid in blood, with prevention gout attacks, helps prevent iron deficiency strengthens immune system. Considering these aspects, be stated that a diet rich vitamin plays an essential role person’s daily food intake. Within present study, we identified content types bell peppers...