A5067549003- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
- Hemoglobin structure and function
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Organic Chemistry Cycloaddition Reactions
- Long-Term Effects of COVID-19
- Cancer Risks and Factors
- Porphyrin Metabolism and Disorders
- Synthesis of Indole Derivatives
- Microbial Natural Products and Biosynthesis
- Catalytic C–H Functionalization Methods
- Acute Lymphoblastic Leukemia research
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- COVID-19 Impact on Reproduction
- Infant Development and Preterm Care
- Ginkgo biloba and Cashew Applications
- RNA modifications and cancer
- Phytochemistry and Bioactivity Studies
- Glycogen Storage Diseases and Myoclonus
- Sulfur-Based Synthesis Techniques
Universidade Federal do Ceará
2016-2025
Abstract Double ruthenium(II)‐catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step‐economical access to valuable with wide range applications. C−H/N−H activations for naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power the thus‐obtained was reflected their antileukemic activity.
We report the synthesis of 47 new quinone-based derivatives via click chemistry and their subsequent evaluation against cancer cell lines control L929 murine fibroblast line. These compounds combine two redox centers, such as an ortho-quinone/para-quinone or quinones/selenium with 1,2,3-triazole nucleus. Several these present IC50 values below 0.5 μM in significantly lower cytotoxicity line good selectivity index. Hence, our study confirms use a complete very diverse range quinone potential...
Abstract Undivided electrochemical cells enable economical preparation of sulphur‐containing naphthoquinones through sulphenylation quinoidal compounds. The environmentally friendly and efficient protocol eliminates the use chemical oxidants facilitates synthesis desired molecules. This approach offers an versatile method to synthesize quinones that exhibit cytotoxicity against cancer cell lines.
In 2021, our research group published the prominent anticancer activity achieved through successful combination of two redox centres (ortho-quinone/para-quinone or quinone/selenium-containing triazole) a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The naphthoquinoidal substrates towards synergetic product was indicated, but not fully explored. Herein, we report synthesis 15 new quinone-based derivatives prepared from click chemistry reactions and their subsequent evaluation...
A utilização de produtos naturais no desenvolvimento novos fármacos tem sido amplamente discutida nos últimos 50 anos. Nesse sentido, a biodiversidade diversos países influencia maneira significativa na descoberta novas moléculas bioativas, como os quimioterápicos origem natural vimblastina e taxol. bioprospecção, que se refere à coleta espécies vegetais para serem testadas em modelos screening e, posteriormente, técnicas analíticas, gera diversas cujas atividades podem configurar potenciais...
The aim of this study is to investigate the structural organization and oligomerization properties sensory kinase protein DevS using low-angle light scattering (LALS) gel filtration chromatography (HPLC). In addition, characteristics FixL BSA were investigated compared with better elucidate LALS technique. a direct specific O<sub>2</sub> sensing in <i>Mycobacterium tuberculosis </i>and acts as an activator transcription factor DevR. This latter triggers latency state under hypoxic...
Toads of the Rhinella genus have a pair paratoid glands that store biological secretions high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out investigation metabolomic profile evaluation potential secretion (PGS) from granulosa. was collected Piauí state (Brazil), extracted with methanol extract analyzed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Fifty constituents were...