A5016260651- Cardiac Valve Diseases and Treatments
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Mitochondrial Function and Pathology
- Transplantation: Methods and Outcomes
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neonatal and fetal brain pathology
- Infective Endocarditis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Fatty Acid Research and Health
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Cancer, Hypoxia, and Metabolism
- Cardiac pacing and defibrillation studies
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Hippo pathway signaling and YAP/TAZ
- Polyamine Metabolism and Applications
- Adipose Tissue and Metabolism
Queen Mary Hospital
2018-2024
University of Hong Kong
2006-2022
Punjab Agricultural University
1980
Perinatal hypoxia and ischemia (HI) are a significant cause of mortality morbidity. To understand the molecular mechanisms for HI-induced brain damage, here we used proteomic approach to analyze alteration modification proteins in neonatal mouse 24 h after HI treatment. Significant changes collapsin response mediator (CRMPs) were observed brain. CRMPs family cytosolic involved axonal guidance neuronal outgrowth. We found that CRMP2, CRMP4 CRMP5 altered post-translationally Mass spectrometric...
Abstract. Background: Child abuse and suicide among the young population is a serious prevalent problem. Many studies have demonstrated that people with adverse childhood experiences, such as child abuse, are likely to develop suicidal behavior. This study evaluates connection between behavior in Hong Kong community where incidents of been on rise over past decade. Aims: To determine association attempted using hospital electronic medical records system. Method: From January 1, 1995 July 31,...
Abstract Background Using texture features derived from contrast-enhanced computed tomography (CT) combined with general imaging as well clinical information to predict treatment response and survival in patients hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) treatment. Methods From January 2014 November 2022, 289 HCC underwent TACE were retrospectively reviewed. Their was documented. treatment-naïve CTs retrieved reviewed by two independent radiologists....
Abstract Purpose In a neonatal rat model of hypoxic–ischemic (HI) brain injury, using T2‐weighted imaging (T2WI) and diffusion‐weighted (DWI), we aim to determine the best MRI method lesion quantification that reflects infarct size. Materials methods Twenty 7‐day‐old rats underwent 24 h after HI injury was induced. Lesion size relative whole measured T2WI apparent diffusion coefficient (ADC) maps, applying thresholds 60%, 70% 80% contralateral control hemisphere mean ADC, at day 10 post‐HI...
Abstract Background Total arch replacement with the frozen elephant trunk (FET) procedure has changed landscape of therapy for aortic diseases. The optimal landing zone a FET is controversial. We sought to share our early and midterm results as well compare clinical outcomes proximal distal anastomosis. Methods A total 100 patients who underwent using technique were identified between November 2014 August 2021. According anastomosis over arch, classified into two groups (zone 0/1 vs. 2/3)....
Left ventricular assist device (LVAD) has been increasingly used in patients with advanced heart failure. This study aimed to assess the impact of implementation LVAD therapy on transplantation (HTx) service Hong Kong (HK).LVAD program was started 2010 HK and who had put HTx waiting list since start from 1992 2020 were included for analysis. Survival between pre-LVAD era 1992-2009 post-LVAD 2010-2020 analyzed by Kaplan-Meier method compared log-rank test. Multivariate analysis time-dependent...
Stroke remains one of the most important complications cardiac surgery and occurs in 2.2% after open-heart procedure. It is associated with significant morbidity mortality. The use a cerebral protection system during transcatheter aortic valve implantation may be lower risk periprocedural strokes, mortality at 30 days. aim present study was to assess safety feasibility this device patients high for stroke open surgery.We six perioperative who underwent placement Sentinel various operations...
Background: Postcongenital heart surgery pulmonary regurgitation requires subsequent valve replacement. We sought to compare the outcomes of replacement after using bioprosthetic valves, porcine versus pericardial bioprosthesis. Method: Retrospective single-center study consecutive in patients with following initial congenital cardiac surgery. From 2004 2016, 82 adult (53 males, 29 females) underwent at a mean age 28.7 ± 8 years (range 18-52 years) time 24 7 13-43 years). Porcine valves...
Abstract We present a case to demonstrate the feasibility of transapical beating heart mitral valve repair in patient with dextrocardia. This minimally invasive technique provides simple, safe and satisfactory repair. The surgical technique, outcome prognosis are not affected by condition.
Aim Risk stratification is an important tool in preoperative decision‐making, counseling, informed consent and quality improvement. The European System for Cardiac Operative Evaluation (logistic EuroSCORE) EuroSCORE II were designed the assessment of surgical risk. However, there are significant geographical demographic differences between Hong Kong patients. Queen Mary Hospital (QMH) risk score a model to predict in‐hospital mortality patients undergoing coronary artery bypass grafting...
Transmembrane 29 (
Descriptions are given for the graphical determination of molecular pK values from curves logV and p(Km/V) against pH. The arguments based on model dissociation equilibria LAL in equilibrium (AL + LA) A, where A denotes a molecule having two binding sites ligand L.