A5086702446- Pain Management and Placebo Effect
- Empathy and Medical Education
- Complementary and Alternative Medicine Studies
- Mindfulness and Compassion Interventions
- Clinical Reasoning and Diagnostic Skills
- Pain Mechanisms and Treatments
- Psychological Treatments and Assessments
- Dermatology and Skin Diseases
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Acupuncture Treatment Research Studies
- Sex and Gender in Healthcare
- Mental Health and Psychiatry
- Neuroscience, Education and Cognitive Function
- Psychology of Moral and Emotional Judgment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Adipokines, Inflammation, and Metabolic Diseases
- Pediatric Pain Management Techniques
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Patient-Provider Communication in Healthcare
- Obesity and Health Practices
- Allergic Rhinitis and Sensitization
- Social and Intergroup Psychology
Leiden University
2017-2025
Jagiellonian University
2021-2025
Institute of Psychology
2021-2025
Leiden University Medical Center
2019-2021
Czech Academy of Sciences, Institute of Psychology
2017-2020
Creative Commons
2020
Bridge University
2019
Tilburg University
2014
<b><i>Introduction:</i></b> Clinical and laboratory studies demonstrate that placebo nocebo effects influence various symptoms conditions after the administration of both inert active treatments. <b><i>Objective:</i></b> There is an increasing need for up-to-date recommendations on how to inform patients about in clinical practice train clinicians disclose this information. <b><i>Methods:</i></b> Based previous...
Placebo effects are positive outcomes that not due to active treatment components, which may be elicited even when patients aware of receiving an inert substance (open-label). This proof-of-principle study investigated for the first time whether open-label placebo on itch can induced by verbal suggestions alone. Ninety-two healthy volunteers were randomized experimental (open-label suggestions) or control (no groups. Self-reported evoked histamine iontophoresis was primary outcome. In...
Placebo and nocebo effects have been shown to influence subjective symptoms such as itch. These can be induced by influencing outcome expectations through, for example, combining the application of an inert substance (e.g., a cream) with verbal suggestions on anticipated this substance. Interestingly, placebo also occur when it is known that treatment (i.e., open-label placebo). However, no study date has examined efficacy negative positive under similar closed-label concealed...
Observational learning (OBL) can elicit placebo hypoalgesia or nocebo hyperalgesia if pain relief exacerbation is observed after administration. While dispositional empathy has occasionally been associated with increased and responding, the contribution of situational (‘state empathy’) remains elusive. This study addresses this knowledge gap using a validated experimental paradigm. Healthy individuals (n=180, 60% females) were randomized to four groups (placebo-OBL, high-empathy placebo-OBL,...
Implicit gender biases (IGBs) are unconscious evaluations about a person based on gender. IGBs of healthcare providers may affect medical decision making. This study investigated whether and genders patients general practitioners (GPs) influence diagnostics treatment decisions in the context diabetes type 2.Ninety-nine GPs participated this randomized online study. Associations Tasks were used to measure two IGBs, related lifestyle (women have healthier than men) communication (men less...
Observational learning (OBL) (seeing pain/pain treatment in others) can evoke placebo hypoalgesia and nocebo hyperalgesia. Data that compare these effects illuminates the role of expectations empathy are scarce. Healthy participants (n = 105) were randomized to: 1) OBL, 2) or 3) no-observation control group. OBL consisted a model simulating pain relief increase after sham ointment was applied to one arm. Pain evoked with thermal stimuli on both arms (ointment, contralateral) at baseline...
Allergic rhinitis symptoms can be reduced by behaviorally conditioning antihistamine. It is unclear whether these findings extend to histamine-induced itch or work when participants are informed about the procedure (open-label conditioning). The current study aims investigate efficacy of (open-label) antipruritic behavioral for itch.
Placebo effects may occur when it is known that an inert substance given (i.e., open-label placebo). It not yet clear whether these are similar to concealed closed-label) placebo for itch or nocebo can be induced under conditions.Healthy volunteers (n = 112) were randomized (I) closed-label (II) positive suggestions group, (III) (IV) negative group. Participants told, as cover story, a transdermal caffeine patch would applied positively influences cognitive abilities and, side effect,...
Contagious itch can be evoked by observing people scratching. Verbal suggestions about to-be-received influence intensity, as shown placebo research, but it is unknown whether this extends to contagious itch. The current study aimed replicate prior findings that listening scratching and rubbing sounds elicits itch, investigate modulate process. Healthy participants (n = 140) received positive or negative in response the (aimed decrease increase expected respectively), no specific a control....
Short stress management interventions such as relaxation therapy have demonstrated preliminary effectiveness in reducing stress-related problems. A promising tool to strengthen the of relaxation-based is use verbal suggestions, previous research provided evidence that suggestions can induce positive outcome expectancies, facilitate adaptive responses and improve health outcomes. The present experimental proof-of-concept study aimed investigate effects a brief intervention specifically role...
Introduction: Placebo and nocebo effects are positive negative health outcomes that can be elicited by the psychosocial context. They mediated expectations, may emerge in somatic symptoms even when people aware of these effects. Interindividual differences (e.g., personality, affective states) could impact placebo responding, but findings inconsistent. Methods: The current work examined expectation as a mediator association between verbal suggestions (VSs) histamine-induced itch across three...
Negative expectations can increase pain sensitivity, leading to nocebo hyperalgesia. However, the physiological and psychological factors that predispose individuals this phenomenon are still not well understood. The present study examined whether stress induced by a social stressor affects hyperalgesia, effect is mediated self-reported responses. We recruited 52 healthy participants (15 men) who were randomly assigned either Trier Social Stress Test (TSST) or control condition (a friendly...
The study aimed to determine if the pain assessment skills of individual being observed influence observationally induced placebo effects in pain. Participants were randomly assigned two experimental groups and one control group. In groups, participants responses a model who had previously shown either high accuracy (high-accuracy group) or low (low-accuracy differentiating intensity stimuli. exhibited less response stimuli when was administered, more no given. group did not observe anyone...
Observational learning (OBL) can evoke placebo hypoalgesia and nocebo hyperalgesia, however, these effects have rarely been systematically compared. Healthy participants (n=105) were randomised to: 1) OBL, 2) or 3) a no-observation control group. During videotaped model simulated pain relief increase after sham ointment was applied. Thermal evoked on two arms (ointment, control) at baseline post-OBL. A three-way interaction confirmed that OBL modulates pain: F(2,93)=6.08, p=.003, ηp2=.12....
Negative expectations can increase pain sensitivity, leading to nocebo hyperalgesia. However, the physiological and psychological factors that predispose individuals this phenomenon are still not well understood. The present study examined whether stress induced by a social stressor affects hyperalgesia, effect is mediated self-reported responses. We recruited 52 healthy participants (15 men) who were randomly assigned either Trier Social Stress Test (TSST) or control condition (a friendly...