A5040079560- Aortic aneurysm repair treatments
- Mitochondrial Function and Pathology
- Fluoride Effects and Removal
- Cancer, Hypoxia, and Metabolism
- Acute Kidney Injury Research
- Metabolism, Diabetes, and Cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Infectious Aortic and Vascular Conditions
- Heme Oxygenase-1 and Carbon Monoxide
- Aortic Disease and Treatment Approaches
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
Lund University
2020-2024
Skåne University Hospital
2022-2023
Wallenberg Wood Science Center
2023
The aim of this study is to investigate how genetic variations in genes related oxidative stress, intake antioxidant vitamins, and any potential interactions between these factors affect the incidence intact abdominal aortic aneurysm (AAA) its rupture (rAAA), accounting for sex differences where possible. present retrospective cohort (n = 25 252) uses baseline single-nucleotide polymorphisms (SNPs) total vitamin data from large population-based, Malmö Diet Cancer Study. Cumulative AAA was...
Abdominal aortic aneurysm (AAA) is a life-threatening condition with mortality rate of over 80%. Persistent smoking, which risk factor for AAA, has lasting effects on DNA methylation. Moreover, plasma-amino acid, homocysteine, previously implicated in vascular diseases, including aneurysms, well-established biological association In the present study, we aimed to determine global methylation, homocysteine levels and their AAA its growth. Enzyme-linked immunosorbent assay (ELISA) was used...
Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s 10,000s per cell, thus providing a potentially alternative identify potential missing circulation at an stage.To characterize mutation landscapes breast cancer, whole mtDNA sequencing bioinformatics analyses were performed on 86 biopsies 50 available...
Background Abdominal aortic aneurysm (AAA) is a vascular disease with mortality rate of >80% if ruptured. Mitochondrial dysfunction has been previously implicated in AAA pathogenesis. In this study, we aimed to characterize the mitochondrial genetic landscape AAA. Methods and Results Whole genome sequencing bioinformatics analysis were performed comorbidity matched 48 cases without AAA, objectively diagnosed, selected from cohort 65-year-old men recruited for screening program. We identified...
Abstract Background There is increasing evidence implicating hemoglobin/heme and their scavengers in oxidative stress-mediated pathologies, but information limited abdominal aortic aneurysm (AAA). Methods results In this case-control study, we assessed heme/heme-related markers 142 men with AAA 279 a normal diameter consecutively recruited from an ultrasound screening program Sweden. Enzyme-linked immunosorbent assays (ELISAs) were used to measure heme oxygenase-1 (HO-1) hemopexin (Hpx)...