The incidence of coronary mortality is higher among populations with low dietary intake flavonoids * protective effect was associated a diet high in apples and onions may be mediated through prevention oxidation density lipoproteins but other mechanisms could involved Flavonoids offer an explanation for the suggested beneficial fruits vegetables heart disease Further studies should concentrate on effects various flavonoid compounds different intakes significantly to antioxidant vitamins C or...

The Venereal Disease Research Laboratory (VDRL) test has long been considered the best serological for diagnosis of neurosyphilis. goal this study was to find out if Rapid Plasma Reagin (RPR) could be an alternative VDRL. Cerebrospinal fluid (CSF) and sera samples from patients in following stages syphilis were tested: 8 had symptomatic 16 asymptomatic neurosyphilis, 4 primary stage, 6 secondary syphilis, 92 latent stage. We have also studied 61 individuals with treated 126 other...

In this study, polymerase chain reaction (PCR) techniques were used to detect Treponema pallidum DNA in samples from patients with latent syphilis. Sixty-nine syphilis and 18 treated included. Whole blood, plasma, sera ear scrapings, totalling 235 syphilis, obtained. Three PCR assays (47-PCR, polA-PCR M-PCR assays) performed. The 47-PCR yielded the highest number of positive -92/235 (39.1%), followed by -90/235 (38.3%) -73/235 (31.1%). Ear scrapings presented positives (47/84 -56%), plasma...

Background Laboratory diagnosis of neurosyphilis is complicated especially when it asymptomatic, no single laboratory test result being appropriate to diagnose central nervous system infectivity caused by Treponema pallidum . Our objective was evaluate two polymerase chain reaction (PCR) techniques for the detection T. DNA in cerebrospinal fluid (CSF) patients with syphilis. Methods One hundred twenty‐four CSF samples from reactive blood tests syphilis were obtained. Two PCR (47‐PCR, pol...

In Mozambique, the prevalence of malaria in children under 5 years age is among highest world, but limited data exist on determinants care-seeking behaviour for malaria. This study aimed at determining trends and factors associated with fever to assess treatment practices Secondary analysis two cross-sectional studies. Descriptive statistics were used summarize socio-economic demographic characteristics participants, using from 2011 Demographic Health Survey 2015 Indicators Immunization,...

In 2023, the HIV-1 pandemic claimed around 630,000 lives worldwide due to AIDS-related complications. Its burden is significantly heavier in Sub-Saharan Africa, where an increased genetic diversity common, which increases risk of resistance antiretroviral (ARV) drugs. This study aims update molecular epidemiology Angola, focusing specifically on gag gene, often overlooked, and assess potential viability lenacapavir (LEN)-based ARV therapy region. A total 243 blood samples were collected from...

The objectives of this study were to evaluate the reproducibility a molecular method for subtyping Treponema pallidum subsp. and discriminate strains microorganism from patients with syphilis. We studied 212 specimens total 82 different stages syphilis (14 primary, 7 secondary 61 latent syphilis). distributed as follows: genital ulcers (n = 9), skin mucosal lesions 7), blood 82), plasma ear lobe scrapings 32). samples assayed by PCR technique amplify segment polymerase gene I (polA)....

Abstract Background Pregnant adolescents have a high incidence of sexually transmitted infections and higher risk adverse birth outcome. Objectives To assess the prevalence in pregnant associations between these Methods A prospective study with face‐to‐face interview to was followed by first‐void urine cervical swabs collection for polymerase chain reaction testing Chlamydia trachomatis Neisseria gonorrhoeae . After child delivery, clinical files were also reviewed serological...

Adolescent childbirth is a major public health problem in Sao Tome and Principe (STP). pregnancy can carry risk of morbidity associated with the physiological sociological characteristics teenage girls. This study aims to identify main adverse obstetric perinatal outcomes for adolescent pregnancies Hospital Dr. Ayres de Menezes (HAM), only hospital STP.An institution-based cross-sectional study. Pregnant women ≤ 19 years age (n = 104) were compared non-adolescent 414). The between groups...

Abstract Background Pregnancy starts early in Sao Tome and Principe (STP) rates of adolescent pregnancy increased 16% recent years reaching a 27.3% prevalence. This study aimed to understand the pregnant adolescents’ characteristics factors associated childbearing STP. Methods A cross-sectional hospital-based was undertaken Hospital Dr. Ayres de Menezes between 2016 2018 with randomly selected total sample size 518 mothers. Mothers’ clinical records interviews were used collect relevant...

Background Neonatal mortality reduction is a global goal, but its factors are seldom studied in most resource-constrained settings. This the first study conducted to identify affecting perinatal and neonatal deaths Sao Tome & Principe (STP), smallest Central Africa country. Methods Institution-based prospective cohort at Hospital Dr. Ayres Menezes. Maternal-neonate dyads enrolled were followed up after 28th day of life ( n = 194) for identification death-outcome 22) alive-outcome...

Human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV) and syphilis remain major infections around the world. In Angola there are about 166 000 individuals living with HIV, representing a prevalence of 1.98% in adults between 15 49 years age. 2003 study Luanda, 4.5% pregnant women had antibodies to HIV 8.1% HBV, 5.4% were infected Treponema pallidum. Objectives. The aim this was determine HIV-1 2, HCV T. pallidum serological markers, hence these infections, attending sexually...

Central Nervous System (CNS) thrombosis is a complication of acute lymphoblastic leukaemia (ALL) treatment that potentially associated with significant morbidity and neurological sequelae. Its presumably multifactorial aetiology poorly characterized. We conducted single-centre, retrospective cohort study on 346 ALL paediatric patients (1-16 years old) treated asparaginase intensive Dana Farber Cancer Institute (DFCI) protocols from 1998 to 2011. The incidence, risk factors outcome CNS were...

Abstract Background Sao Tome & Principe (STP) has a high peri-neonatal mortality rate and access to high-quality care before childbirth been described as one of the most effective means reducing it. The country gap in coverage-content antenatal (ANC) services that must be addressed better allocate resources ultimately improve maternal neonatal health. Therefore, this study aimed identify determinants for adequate ANC utilization considering number timing contacts screening completion....

Introduction: Intestinal parasites are known to cause infection in humans worldwide, with higher prevalence low- and middle- incoming countries. Children greatly affected leading malnutrition subsequently physical cognitive development impairment. Despite the scale importance of this issue, there few studies conducted Mozambique concerning parasitic intestinal infections hospitalized children. To our knowledge is first published report data on subject from Northern Mozambique.
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Intestinal parasitic infections (IPIs) are a public health problem in developing countries such as Sao Tome and Principe (STP) although the pregnancy burden of IPIs is unknown this endemic country. Thus, aim study was to determine prevalence IPIs, prescribed anthelmintics, associated factors among pregnant women admitted Hospital Dr. Ayres de Menezes (HAM).

O presente estudo teve como objetivo proceder à validação da Functional Assessment of Cancer Therapy-General (FACT-G) versão 4, de Cella et al. (1993) cultura portuguesa, em contexto doentes oncológicos na fase final vida acompanhados cuidados paliativos.Esta escala foi desenvolvida com o avaliar a qualidade geral do doente oncológico quatro domínios: Bem-estar Físico (PWB/BEFI); Funcional (FWB/

the study period.The inflationary influences on prescribing costs discussed in introduction have been more important than all of cost control (of which fundholding was only one) combined.The effect marketing pressure from pharmaceutical industry is probably most powerful these influences; it discernible this increase per item drugs for diseases central nervous system and gastrointestinal disorders.No clinical research evidence exists that

Newborn mortality and adverse birth outcomes (ABOs) in Sao Tome & Príncipe (STP) are overwhelmingly high, access to quality-antenatal care (ANC) is one of the strategies tackle it. This study aimed fill gaps ANC screenings with a focus on how improve neonatal outcomes. We conducted retrospective hospital-based which pregnancy cards were reviewed. Screenings described compared according total number contacts: 1-3 (inadequate), 4-7 (adequate), ≥8 (complete). The collected data entered into...

Objectives To characterise infections by HIV, Treponema pallidum, hepatitis B (HBV) and C virus (HCV) in parturients admitted to Irene Neto Maternity, Lubango city, Huíla province, Angola, namely its seropositivity rate association with sociodemographic factors. Methods An observational, cross-sectional analytical facility-based survey was conducted among 500 at from October 2016 September 2017. Women labour were screened for antibodies against HIV-1/2, T. pallidum HCV. Antigen detection...

In Brief We described the evaluation of Syphilis Screening & Confirm Assay for simultaneous detection nontreponemal and treponemal antibodies. A total 248 samples were evaluated. The sensitivity tests was 98.8%, 99.5% 98.9%, while specificity 94.7%, 88.9% 93.2%, respectively, as compared with rapid plasma reagin, Treponema pallidum hemagglutination assay, fluorescent antibody absorption tests. is a POC test that detects antibodies shows similar to syphilis standard laboratory