A5101930274- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Potassium and Related Disorders
- Auditing, Earnings Management, Governance
- Corporate Finance and Governance
- Renal Diseases and Glomerulopathies
- Magnesium in Health and Disease
- Membrane-based Ion Separation Techniques
- Financial Reporting and Valuation Research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Genetic and Kidney Cyst Diseases
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Chemical Synthesis and Characterization
- Financial Markets and Investment Strategies
- Renal and Vascular Pathologies
- Wnt/β-catenin signaling in development and cancer
- Advanced Statistical Methods and Models
- Genetics and Plant Breeding
- Statistical Distribution Estimation and Applications
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Lymphatic Disorders and Treatments
State Key Laboratory of Plant Genomics
2025
Chinese Academy of Sciences
2025
Jiangsu University
2010-2024
Zhejiang Hospital
2024
First People's Hospital of Kunshan
2010-2024
Wen's Food Group (China)
2022-2023
Northwest University
2022
Xiamen University
2015-2021
Creative Commons
2021
Zhongshan People's Hospital
2017-2021
Abstract In response to inflammation stimuli, tumor necrosis factor‐α (TNF‐α) induces expression of cell adhesion molecules (CAMs) in endothelial cells (ECs). Studies have suggested that the nuclear factor‐κB (NF‐κB) and p38 MAP kinase (p38) signaling pathways play central roles this process, but conflicting results been reported. The objective study is determine relative contributions two effect TNF‐α. Our initial data indicated blockade activity by chemical inhibitor SB203580 (SB) at 10 µM...
Backfat thickness (BFT) is complex and economically important traits in the pig industry, since it reflects fat deposition can be used to measure carcass lean meat percentage pigs. In this study, all 6,550 pigs were genotyped using Geneseek Porcine 50K SNP Chip identify SNPs related BFT search for candidate genes through genome-wide association analysis two Duroc populations. total, 80 SNPs, including 39 significant 41 suggestive 6 QTLs identified significantly associated with BFT. addition,...
The liver has multiple functions that preserve homeostasis. Liver diseases are debilitating, costly and often result in death. Elucidating the developmental mechanisms establish liver’s architecture or generate cellular diversity of this organ should help advance prevention, diagnosis treatment hepatic diseases. We previously reported migration early precursors away from gut epithelium requires activity homeobox gene Prox1. Here, we show Prox1 is a novel regulator cell differentiation...
The use of whole-genome sequence (WGS) data is expected to improve genomic prediction (GP) power complex traits because it may contain mutations that in strong linkage disequilibrium pattern with causal mutations. However, a few previous studies have shown no or small improvement accuracy using WGS data. Incorporating prior biological information into GP seems be an attractive strategy might accuracy. In this study, total 6334 pigs were genotyped 50K chips and subsequently imputed the level....
TGF-Β1 plays an important role on podocyte injury and glomerular diseases, while the underlying molecular mechanisms are still elusive. Here, potential of ion channel TRPC6 proximal signaling was explored in TGF-Β1-treated mouse podocyte. Our results showed that significantly increased apoptosis induced obvious disorganization actin filaments a time-dependent pattern. In podocyte, protein, especially phosphorylated TRPC6, cytosolic free Ca2+ level upregulated, which evidently inhibited by...
Genomic prediction (GP), which uses genome-wide markers to estimate breeding values, is a crucial tool for accelerating genetic progress in livestock and plant breeding. The accuracy of GP depends on several factors, including the statistical model, marker density, cross-validation strategy. This study evaluated these factors optimize eight economically important carcass body traits Duroc × (Landrace Yorkshire) (DLY) pig population. used 50 K SNP chip data from 1494 DLY pigs, were imputed...
Calciphylaxis is a grievous life-threatening vascular disease that commonly affects dialysis population. This the first epidemiological survey of calciphylaxis initiated in China. In cross-sectional survey, stratified sampling method was used to select 24 centers Jiangsu Province. The participants were all adult patients each center who had been on hemodialysis for more than 6 months. uniformly diagnosed based characteristic skin lesions and histopathological features. A total 3,867 (average...
Recent research in empirical accounting has raised questions about the usefulness of price models, and how this tool can be used properly given its economic econometric problems. This paper first identifies essential distinctions between return situations which a model is advantageous. An alternative method estimating models then developed through minimizing symmetrized relative pricing error (LRPE); Compared to conventional methods deflating by BVE, Shares, lagged price, or itself, LRPE...
Background To analyze the health-related quality of life associated with conversion dialysis modality among end-stage renal disease patients in China. Methods Patients were recruited from hospitals and a center Kunshan, converting continuous ambulatory peritoneal to automated as observation group ( n = 64), continuing treatment included control 64) after matching this retrospective cohort study. Their was measured using kidney instrument 2019 2020, respectively. Baseline socio-demographic...
This paper attempts to scrutinize the impact of natural resources, cultural, geographical, and institutional factors on Chinese OFDI toward OBOR signatories by using Gravity model. The empirical estimates validated a significant positive relationship between China's Partners' GDP, negative influence geographical distance OFDI. Institutional (government effectiveness, corruption control, rule law, voice accountability, regularity quality) have negative, while cultural (shared border, common...
Next-generation sequencing of the metagenome (mNGS) is gaining traction as a valuable tool for diagnosing infectious diseases. Compared to mNGS, pathogen detection based on Oxford Nanopore Technology further shortens time. This study seeks assess efficacy in identifying pathogens associated with community-acquired pneumonia (CAP) among elderly individuals China.
The glomerular visceral epithelial cells, also termed podocytes, are key in maintaining the normal renal filtration barrier. Although it has been demonstrated that stimulation of c‑Maf inducing protein (CMIP) expression is involved podocyte damage, molecular events during this process remain unclear. In current study, CMIP‑induced proximal signaling was investigated by focusing on its effect cofilin‑1 activity puromycin aminonucleoside (PA)‑damaged podocytes. An obvious elevation CMIP and...
The predictive value of soluble Klotho (sKlotho) for adverse outcomes in patients on maintenance hemodialysis (MHD) is controversial. In this study, we aimed to clarify the potential association sKlotho levels with patient population. A total 211 MHD were identified and stratified according median level. Patients followed up including cardiovascular (CV) morbidity all-cause mortality. During 36-month follow-up, 75 [51 CV events (including 16 deaths) 40 deaths] experienced outcomes. After...
This paper studies short sellers' trading strategies and their effects on the financial market by examining accusations of fraud against Chinese reverse merger firms (CRMs) in US. We find that sellers rely firms' fundamental information, especially relative indicators, to locate "prey." Specifically, they compare a target firm's indicators (e.g., growth receivables) with both industry average history. no evidence accuse CRMs simply because label. Additionally, we test accuracy long run...
Aplasia cutis congenita (ACC) is a rare genetic disorder characterized by the localized or widespread absence of skin in humans and animals. Individuals with ACC may experience developmental abnormalities skeletal muscular systems, as well potential complications. Localized isolated cases can be treated through surgical medical interventions, while extensive result neonatal mortality. The presence pigs has implications for animal welfare. It contributes to an elevated mortality rate among...