A5102741323- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Transplantation: Methods and Outcomes
- Multiple and Secondary Primary Cancers
- Trauma Management and Diagnosis
- Metastasis and carcinoma case studies
- Myasthenia Gravis and Thymoma
- Cardiac, Anesthesia and Surgical Outcomes
- Pleural and Pulmonary Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Delphi Technique in Research
- Dysphagia Assessment and Management
- Peripheral Nerve Disorders
- Neuroendocrine Tumor Research Advances
- Viral Infections and Immunology Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
Brigham and Women's Hospital
2015-2024
Harvard University
1996-2024
Dana-Farber Cancer Institute
1999-2023
Dana-Farber Brigham Cancer Center
1999-2019
Wenzhou Medical University
2018
University of Hong Kong
2018
State Key Laboratory of Oncology in South China
2018
AstraZeneca (Canada)
2018
Merck (Netherlands)
2018
Shantou University
2018
The NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management NSCLC. These Insights focus on recent updates in immunotherapy. For the 2020 update, systemic therapy regimens have been categorized using a new preference stratification system; certain are now recommended as "preferred interventions," whereas others either "other interventions" or "useful under circumstances."
Purpose The efficacy of neoadjuvant chemoradiotherapy (NCRT) plus surgery for locally advanced esophageal squamous cell carcinoma (ESCC) remains controversial. In this trial, we compared the survival and safety NCRT with alone in patients ESCC. Patients Methods From June 2007 to December 2014, 451 potentially resectable thoracic ESCC, clinically staged as T1-4N1M0/T4N0M0, were randomly allocated (group CRT; n = 224) S; 227). group CRT, received vinorelbine 25 mg/m2 intravenously (IV) on days...
The primary aim of this trial was to assess the feasibility minimally invasive esophagectomy (MIE) in a multi-institutional setting.Esophagectomy is an important, potentially curative treatment for localized esophageal cancer, but complex operation. MIE may decrease morbidity and mortality resection, single-institution studies have demonstrated successful outcomes with MIE.We conducted multicenter, phase II, prospective, cooperative group study (coordinated by Eastern Cooperative Oncology...
BACKGROUND To improve understanding of the cellular basis arterial response to injury, we tested whether balloon withdrawal can induce certain inflammatory functions vascular cells and leukocytes such "activation" persists even after acute phase injury. METHODS AND RESULTS We examined expression several inducible cell surface molecules in rabbit aorta at 2, 5, 10, 30 days Longitudinal sections encompassing parts uninjured, border, injured zones were for adhesion molecule-1 (VCAM-1),...
Abstract BACKGROUND The presence of lymph node (LN) metastases in esophageal cancer has important prognostic and treatment implications. However, the optimal number LNs that should be examined for accurate staging is controversial. In current study, association between survival evaluated was patients who underwent resection node‐negative (American Joint Committee on Cancer [AJCC] TNM stage I‐IIA) cancer. METHODS All were identified surgery 1988 2003 from Surveillance, Epidemiology, End...
The impact of COVID-19 has been felt in every field medicine. We sought to understand how lung cancer surgery was affected at a high volume institution. hypothesized that patients would wait longer for surgery, have more advanced tumors, and experience complications during the crisis.A retrospective review conducted, comparing pathologically confirmed non-small cell (NSCLC) surgical cases performed 2019 from March May 2020, height crisis. Clinical pathologic stage, tumor size, time follow up...
BACKGROUND Endoscopic ultrasonography (EUS) provides highly accurate preoperative T and N classifications in patients with esophageal carcinoma. Although previous data have suggested that tumors classified as T4 by EUS do not benefit from surgical resection, these were acquired prior to the widespread use of chemoradiation. The current study investigated whether pretreatment can predict a complete response neoadjuvant therapy. METHODS Patients carcinoma (adenocarcinoma or squamous cell...
Induction therapy followed by esophagectomy has become standard for treatment of intermediate-stage esophageal cancer in many centers. Herein we evaluate the feasibility and safety 3-hole minimally invasive (3HMIE) approach patients who received induction radiation chemotherapy. Between 2003 2012, records 119 consecutive with underwent 3HMIE were reviewed perioperative complications long-term outcomes. Comparison was made between procedures performed receiving neoadjuvant chemoradiation...
4516 Background: The incidence of esophagogastric adenocarcinoma (EAC) is increasing at an alarming rate in the United States. Definitive treatment may require a combination surgery (esophagectomy), chemotherapy and radiation. Operative mortality rates after esophagectomy have been reported as high 8–23% (NEJM 2003). Minimally invasive (MIE) decrease morbidity mortality. Previous single institution studies demonstrated successful outcomes with MIE. primary aim this cooperative group protocol...
Background: Thoracic epidural analgesia (TEA) and liposomal bupivacaine (LB) are two methods used for postoperative pain control after thoracic surgery. Some studies have compared LB to standard bupivacaine. However, data comparing the outcomes of TEA minimally invasive lung resection is limited. Therefore, objective our study was compare pain, opioid usage, between patients who received vs. LB. Methods: We conducted a retrospective chart review underwent resections over an 8-month period....